Latent inhibition of conditioned taste aversion in rats with excitotoxic dorsal hippocampal lesions

Molero‐Chamizo, Andrés; Morón, Ignacio

doi:10.1002/jnr.23633

Cited by 7 publications

(5 citation statements)

References 49 publications

(68 reference statements)

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“…We propose that this incongruence may be due to differences in the neural circuitry involved in the acquisition and expression of conditioned taste-immune vs. conditioned opiate-immune effects. It is unclear whether conditioned taste effects require the hippocampus in paradigms not employing a contextual component (Molero-Chamizo and Moron, 2015). In addition, prior studies demonstrated that the amygdala was important for the expression of heroin conditioned immunosuppression (Szczytkowski et al, 2011; Szczytkowski and Lysle, 2008, 2010).…”

Section: Discussionmentioning

confidence: 99%

Acquisition of heroin conditioned immunosuppression requires IL-1 signaling in the dorsal hippocampus

Lebonville

Jones

Hutson

et al. 2016

Brain, Behavior, and Immunity

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Opioid users experience increased incidence of infection, which may be partially attributable to both direct opiate-immune interactions and conditioned immune responses. Previous studies have investigated the neural circuitry governing opioid conditioned immune responses, but work remains to elucidate the mechanisms mediating this effect. Our laboratory has previously shown that hippocampal IL-1 signaling, specifically, is required for the expression of heroin conditioned immunosuppression following learning. The current studies were designed to further characterize the role of hippocampal IL-1 in this phenomenon by manipulating IL-1 during learning. Experiment 1 tested whether hippocampal IL-1 is also required for the acquisition of heroin conditioned immunosuppression, while Experiment 2 tested whether hippocampal IL-1 is required for the expression of unconditioned heroin immunosuppression. We found that blocking IL-1 signaling in the dorsal hippocampus with IL-1RA during each conditioning session, but not on interspersed non-conditioning days, significantly attenuated the acquisition of heroin conditioned immunosuppression. Strikingly, we found that the same IL-1RA treatment did not alter unconditioned immunosuppression to a single dose of heroin. Thus, IL-1 signaling is not a critical component of the response to heroin but rather may play a role in the formation of the association between heroin and the context. Collectively, these studies suggest that IL-1 signaling, in addition to being involved in the expression of a heroin conditioned immune response, is also involved in the acquisition of this effect. Importantly, this effect is likely not due to blocking the response to the unconditioned stimulus since IL-1RA did not affect heroin’s immunosuppressive effects.

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Section: Discussionmentioning

confidence: 99%

Acquisition of heroin conditioned immunosuppression requires IL-1 signaling in the dorsal hippocampus

Lebonville

Jones

Hutson

et al. 2016

Brain, Behavior, and Immunity

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“…Liking and disliking reactions are strictly linked to activation of the insular cortex, hypothalamus, hippocampus, amygdala, and other structures of the limbic system; thereby, the recollection of previously experienced unkind feelings and emotions in response to certain stimuli or situations may contribute to unpleasant and sometimes disgusting perception (Doty and Bromley, ). However, Molero‐Chamizo and Moron () recently found that the latent inhibition of conditioned taste aversion was not compromised in rats with excitotoxic dorsal hippocampal lesions. Different subregions of the hippocampus are associated with distinct functions, and the authors hypothesized a selective involvement of specific regions of this structure (Molero‐Chamizo and Moron, ).…”

Section: Pleasant Stimuli May Mask Emetogenic Disgusting Stimulimentioning

confidence: 99%

“…However, Molero‐Chamizo and Moron () recently found that the latent inhibition of conditioned taste aversion was not compromised in rats with excitotoxic dorsal hippocampal lesions. Different subregions of the hippocampus are associated with distinct functions, and the authors hypothesized a selective involvement of specific regions of this structure (Molero‐Chamizo and Moron, ). Moreover, we cannot exclude the possibility that the neuronal pathways activated by early limbic system‐triggered nausea are so oppressive that the evoked pleasant‐odor map is unable to mask the unpleasant one.…”

Section: Pleasant Stimuli May Mask Emetogenic Disgusting Stimulimentioning

confidence: 99%

Potential effects of pleasant and cold stimuli on nausea and vomiting induced by disgusting tastes

Gonella

Dimonte

2016

J of Neuroscience Research

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Several pharmacological agents have disgusting tastes that are perceived strongly in the back of the mouth and may trigger nausea and vomiting (NV), resulting in poor adherence to medication schedules and negative impacts on clinical outcomes. Pleasant stimuli and cold temperature lessen the disgusting stimuli, lowering NV through different mechanisms. A pleasant stimulus can mask an unpleasant one, presumably through lateral inhibitory connections in the local neuronal circuit. Similarly, temperature deeply influences taste perception because the response to bitter as well as to salty and sour has been found to assume a reversed U-shaped form, being reduced by cooling to 18°C and enhanced by warming to 30-37°C. This Review describes the mechanisms by which pleasant and cold stimuli may mask emetogenic disgusting stimuli and identifies the potential clinical applications of cooling for inhibiting objectionable drug-related gustatory reactions. © 2015 Wiley Periodicals, Inc.

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“…Considering this physiological time interval between the taste processing and the gastrointestinal malaise, CTA could result from the association between the taste memory’s trace and the visceral disease. The CTA paradigm used in the laboratory is a useful tool to investigate the biological and behavioural bases of aversive learning and taste memory, not only regarding the specificity of CTA but also with respect to other taste learning phenomena, such as neophobia (a precautionary response to the first exposure to a novel food or taste) or latent inhibition of CTA (a reduced conditioned aversion resulting from taste pre-exposures without negative or aversive consequences) [ 32 , 33 , 34 , 35 ]. An example of the relevance of the CTA paradigm is the finding that physical (external) and internal (such as the time of day) cues can separately modulate the magnitude of a learned aversion [ 36 , 37 , 38 ].…”

Section: Taste Learningmentioning

confidence: 99%

Taste Processing: Insights from Animal Models

Molero‐Chamizo

Rivera-Urbina

2020

Molecules

Self Cite

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Taste processing is an adaptive mechanism involving complex physiological, motivational and cognitive processes. Animal models have provided relevant data about the neuroanatomical and neurobiological components of taste processing. From these models, two important domains of taste responses are described in this review. The first part focuses on the neuroanatomical and neurophysiological bases of olfactory and taste processing. The second part describes the biological and behavioral characteristics of taste learning, with an emphasis on conditioned taste aversion as a key process for the survival and health of many species, including humans.

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Latent inhibition of conditioned taste aversion in rats with excitotoxic dorsal hippocampal lesions

Cited by 7 publications

References 49 publications

Acquisition of heroin conditioned immunosuppression requires IL-1 signaling in the dorsal hippocampus

Acquisition of heroin conditioned immunosuppression requires IL-1 signaling in the dorsal hippocampus

Potential effects of pleasant and cold stimuli on nausea and vomiting induced by disgusting tastes

Taste Processing: Insights from Animal Models

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