Latent class growth analysis successfully identified subgroups of participants during a weight loss intervention trial

Vos, Bastiaan C. de; Runhaar, Jos; Verkleij, Saskia; Middelkoop, Marienke van; Bierma-Zeinstra, Sita M A

doi:10.1016/j.jclinepi.2014.03.007

Cited by 7 publications

(12 citation statements)

References 11 publications

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“…Confounding factors could distort this association. For example, a secondary analysis on data derived from the PROOF study showed, among other things, that participants with a relatively low body weight around their 40th year of life were more likely to lose weight during the study (42). This could mean that the group that lost 5 kg or 5% of their body weight is, in fact, a group of participants with an overall healthier lifestyle, which could account for the better health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females

Runhaar

Vos

Middelkoop

et al. 2016

Arthritis Care & Research

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Objective. This study evaluated the effect of moderate weight loss on the incidence of knee osteoarthritis (OA) in middle-aged overweight and obese women, without clinical and radiologic knee OA at baseline. Methods. A total of 353 women (87%) with followup data available were selected from the Prevention of Knee Osteoarthritis in Overweight Females study, which evaluated the preventive effect of a diet and exercise intervention and of oral glucosamine sulfate on the incidence of knee OA. This was an exploratory proof-of-concept analysis, which compared the incidence of knee OA between women who reached the clinically relevant weight loss target of 5 kg or 5% of body weight after 30 months and those who did not reach this target. Results. The weight loss group showed a significantly lower incidence of knee OA according to the primary outcome measure, which was composed of the American College of Rheumatology criteria (clinical and radiographic), Kellgren/Lawrence grade ‡2, and joint space narrowing ‡1.0 mm (15% versus 20%; odds ratio 0.5, 95% confidence interval 0.3-0.9). Moreover, the weight loss also positively affected several health measures, such as blood glucose level, body fat percentage, and blood pressure. Conclusion. A reduction of ‡5 kg or 5% of body weight over a 30-month period reduces the risk for the onset of radiographic knee OA in middle-aged overweight and obese women. Because of the slow progression of the disease, a longer followup period will be necessary before the number of prevented cases of knee OA by moderate weight loss becomes clinically more relevant.

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Section: Discussionmentioning

confidence: 99%

Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females

Runhaar

Vos

Middelkoop

et al. 2016

Arthritis Care & Research

Self Cite

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“…Previously de Vos and colleagues 15 used growth mixture modelling to identify trajectories in a weight loss trial in overweight women which investigated the effectiveness of an individualised intervention for weight loss compared with a control who received no intervention. Their study differed from the present study in several ways.…”

Section: Discussionmentioning

confidence: 99%

Baseline characteristics associated with different BMI trajectories in weight loss trials: a case for better targeting of interventions

2015

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Background/Objectives: Dietary weight loss interventions have heterogeneous outcomes in long-term studies, with many participants regaining part or all of the lost weight. Growth mixture modelling is a novel analytic approach that can be used to identify different trajectories of weight change during a trial rather than focussing on the total amount of weight lost. Subjects/Methods: Data were pooled from two 12-month dietary weight loss studies where no significant difference was detected between the treatment and control arms, thus allowing analysis independent of treatment. The data set included 231 subjects (74.5% female), with a mean weight loss of 6.40 kg (4.96). Growth mixture models were used to identify participants with similar trajectories of change in body mass index (BMI). Results: Three subgroups were identified. A rapid and continuing BMI loss over the study period (rapid, n=53), a rapid initial weight loss in the first 3 months with a slowing rate over the remaining 9 months (maintainers, n=146) and those with an initial loss trajectory, which slowed and began to increase at 9 months (recidivists, n=53). Age (s.d.) and BMI (s.d.) were significantly different between the three groups (rapid 53 years (7), 28.99 kg/m2 (3.30); maintainers 47 years (9), 30.90 kg/m2 (2.95); recidivists 44 years (7), 34.84 kg/m2 (1.92), both P<0.001). Conclusions: Older subjects with lower BMIs were more likely to have a rapid and continuing weight loss in a 1-year dietary-based weight loss intervention. Different interventional approaches may be necessary for different ages and baseline BMIs and stratification prior to randomisation may be necessary to prevent confounding in weight loss trials.

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“…For the present study, we used three weight change subgroups, identified previously with LCGA using six-monthly weight data 20 . This three-group model showed the best fit to the data according to objective parameters and had the best usefulness of the latent classes 20 .…”

Section: Evaluation Of Changes In Body Weight Over Timementioning

confidence: 99%

“…As a disadvantage, subjects with fluctuations in BMI during follow-up were not distinguished from those with steady weight loss. Recently, Latent Class Growth Analysis (LCGA) successfully identified three subgroups with different weight change during 2.5 years within the PROOF Study 20 .…”

Section: Introductionmentioning

confidence: 99%

Effect of weight change on progression of knee OA structural features assessed by MRI in overweight and obese women

Landsmeer

Vos

Plas³

et al. 2018

Osteoarthritis and Cartilage

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Latent class growth analysis successfully identified subgroups of participants during a weight loss intervention trial

Cited by 7 publications

References 11 publications

Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females

Prevention of Incident Knee Osteoarthritis by Moderate Weight Loss in Overweight and Obese Females

Baseline characteristics associated with different BMI trajectories in weight loss trials: a case for better targeting of interventions

Effect of weight change on progression of knee OA structural features assessed by MRI in overweight and obese women

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