Effect of weight change on progression of knee OA structural features assessed by MRI in overweight and obese women

Landsmeer, M.L.; Vos, Bastiaan C. de; Plas, Peter van der; Middelkoop, Marienke van; Vroegindeweij, Dammis; Bindels, Patrick J E; Oei, E.H.; Bierma-Zeinstra, Sita M A; Runhaar, Jos

doi:10.1016/j.joca.2018.08.006

Cited by 30 publications

(18 citation statements)

References 41 publications

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“…Multiple studies have investigated the influence of weight gain and weight loss on changes in knee structural pathology. Landsmeer et al compared changes in MRI findings over 96 months between 260 obese women without knee OA with stable weight, 43 women with weight gain, and 44 women with weight loss from the Prevention of Knee Osteoarthritis in Overweight Females (PROOF) study 9 . Women with weight gain showed greater progression of synovitis, patellofemoral cartilage defects, and patellofemoral bone marrow edema lesions compared to women with stable weight 9 10 .…”

Section: Obesity In Knee Oamentioning

confidence: 99%

Osteoarthritis year in review 2019: imaging

Kijowski

Demehri

Roemer

et al. 2020

Osteoarthritis and Cartilage

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PET-MRI". Articles were reviewed to determine relevance based upon the following criteria: 1) study involved human subjects with OA or risk factors for OA and 2) study involved imaging to evaluate OA disease status or OA treatment response. Relevant articles were ranked according to scientific merit, with the best publications selected for inclusion in the narrative report. Results: The PubMed search revealed a total of 1257 articles, of which 256 (20.4%) were considered relevant to OA imaging. Two-hundred twenty-six (87.1%) articles involved the knee joint, while 195 (76.2%) articles involved the use of magnetic resonance imaging (MRI). The proportion of published studies involving the use of MRI was higher than previous years. An increasing number of articles were also published on imaging of subjects with joint injury and on deep learning application in OA imaging. Conclusion: MRI and other imaging modalities continue to play an important role in research studies designed to better understand the pathogenesis, progression, and treatment of OA.

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Section: Obesity In Knee Oamentioning

confidence: 99%

Osteoarthritis year in review 2019: imaging

Kijowski

Demehri

Roemer

et al. 2020

Osteoarthritis and Cartilage

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“…48 Specifically, Zhang et al 48 showed that a high BMI can result in increased extrusion of the medial meniscus compared with a normal BMI, potentially altering the size and area of the cartilage covered by the meniscus. Landsmeer et al 25 also demonstrated that meniscal extrusion is diminished with weight loss, further supporting the concept that changes in weight can alter meniscal position. In support of this, our results demonstrated greater cartilage strains in participants with high BMI, in regions both covered and uncovered by the menisci.…”

Section: Discussionmentioning

confidence: 76%

The Influence of Obesity and Meniscal Coverage on In Vivo Tibial Cartilage Thickness and Strain

Collins

Kulvaranon

Spritzer

et al. 2020

Orthopaedic Journal of Sports Medicine

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Background: Obesity, which potentially increases loading at the knee, is a common and modifiable risk factor for the development of knee osteoarthritis. The menisci play an important role in distributing joint loads to the underlying cartilage. However, the influence of obesity on the role of the menisci in cartilage load distribution in vivo is currently unknown. Purpose To measure tibial cartilage thickness and compressive strain in response to walking in areas covered and uncovered by the menisci in participants with normal body mass index (BMI) and participants with high BMI. Study Design: Controlled laboratory study. Methods: Magnetic resonance (MR) images of the right knees of participants with normal BMI (<25 kg/m2; n = 8) and participants with high BMI (>30 kg/m2; n = 7) were obtained before and after treadmill walking. The outer margins of the tibia, the medial and lateral cartilage surfaces, and the meniscal footprints were segmented on each MR image to create 3-dimensional models of the joint. Cartilage thickness was measured before and after walking in areas covered and uncovered by the menisci. Cartilage compressive strain was then determined from changes in thickness resulting from the walking task. Results: Before exercise, medial and lateral uncovered cartilage of the tibial plateau was significantly thicker than covered cartilage in both BMI groups. In the uncovered region of the lateral tibial plateau, participants with high BMI had thinner preexercise cartilage than those with a normal BMI. Cartilage compressive strain was significantly greater in medial and lateral cartilage in participants with high BMI compared with those with normal BMI in both the regions covered and those uncovered by the menisci. Conclusion: Participants with high BMI experienced greater cartilage strain in response to walking than participants with normal BMI in both covered and uncovered regions of cartilage, which may indicate that the load-distributing function of the meniscus is not sufficient to moderate the effects of obesity. Clinical Relevance: These findings demonstrate the critical effect of obesity on cartilage function and thickness in regions covered and uncovered by the menisci.

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“… 18 Indeed, weight gain led to an increased progression of knee OA structural features, synovitis, patellofemoral bone marrow lesions (BMLs) and cartilage defects in overweight and obese women over 2.5 years. 19 In contrast, more than 5% weight loss was associated with a slower increase in global cartilage T2 and deep layer cartilage T2 scores compared with stable weight after a follow up of 96 months. 20 Furthermore, weight loss was also associated with improvements in the quality (increased proteoglycan content) and quantity (reduced thickness loss) on medial knee articular cartilage over 1 year.…”

Section: Outcomes and Endpoints According To Knee Oa Phenotypesmentioning

confidence: 79%

Setting up distinctive outcome measures for each osteoarthritis phenotype

Roman‐Blas

Mendoza-Torres²,

Largo

et al. 2020

Therapeutic Advances in Musculoskeletal

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Osteoarthritis (OA) is an evolving chronic joint disease with a huge global impact. Given the intricate nature of the etiopathogenesis and subsequent high heterogeneity in the clinical course of OA, it is crucial to discriminate between etiopathogenic endotypes and clinical phenotypes, especially in the early stages of the disease. In this sense, we propose that an OA phenotype should be properly assessed with a set of outcome measures including those specifically related to the main underlying pathophysiological mechanisms. Thus, each OA phenotype can be related to different and clinically meaningful outcomes. OA phenotyping would lead to an adequate patient stratification in well-designed clinical trials and the discovery of precise therapeutic approaches. A significant effort will be required in this field in light of inconclusive results of clinical trials of tissue-targeting agents for the treatment of OA.

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Effect of weight change on progression of knee OA structural features assessed by MRI in overweight and obese women

Cited by 30 publications

References 41 publications

Osteoarthritis year in review 2019: imaging

Osteoarthritis year in review 2019: imaging

The Influence of Obesity and Meniscal Coverage on In Vivo Tibial Cartilage Thickness and Strain

Setting up distinctive outcome measures for each osteoarthritis phenotype

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