Latency variability of the components of auditory event-related potentials to infrequent stimuli in aging, Alzheimer-type dementia, and depression

Patterson, Julie V.; Michalewski, Henry J.; Starr, Arnold

doi:10.1016/0168-5597(88)90049-4

Cited by 168 publications

(55 citation statements)

References 28 publications

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“…AmpV factor scores did not, however, distinguish older controls from ADs. At this level of analysis, our results are consistent with those of Patterson et al (1988). They found that measures of latency variability of auditory ERPs were sensitive to AD, but not sufficiently sensitive such that variability indicators could be used to differentiate demented persons on an individual basis for clinical diagnosis.…”

Section: Al 2000)supporting

confidence: 80%

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Electrophysiological and information processing variability predicts memory decrements associated with normal age-related cognitive decline and Alzheimer's disease (AD)

et al. 2006

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Recent theoretical models of cognitive aging have implicated increased intra-individual variability as a critical marker of decline. The current study examined electrophysiological and information processing variability and memory performance in normal younger and older controls, and older adults with Alzheimer's disease (AD). It was hypothesized that higher levels of variability would be indicative of age-related and disease-related memory deficits. Results indicated both implicit and explicit memory deficits associated with AD. There is a great deal of controversy regarding the predictive validity of standard neuropsychological assessments in identifying early cases of dementia (Ritchie and Lovestone, 2002;Ritchie and Touchon, 1992) and the underlying causal factors associated with age-and disease-related decrements in memory and cognition (Anderson and Craik, 2000;Grady and Craik, 2000;Hogan, 2004;Hogan et al., 2003). Theoretical models of neurological aging have implicated increased intra-individual variability as a marker of generalized cognitive decline (Li and Lindenberger, 1998). A number of studies have examined intra-individual variability in older adults using measures of reaction time (Hogan, 2003;Myerson and Hale, 1993;Myerson et al., 1990;Rabbitt and Lowe, 2000;Salthouse, 1993), sensorimotor ability (Li et al., 2001), and cognitive ability (Hertzog et al., 1992;Hultsch et al., 2002). Results support the conclusion that levels of intra-individual variability increase with advancing age.

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Section: Al 2000)supporting

confidence: 80%

“…Patterson et al (1988) examined latency variability of auditory event-related potentials (ERPs) in 15 demented, 8 depressed, and 15 normal older, and 12 normal young, participants. Latency variability measures from single trials were derived for the N1, P2, N2, and P3 components of the ERP.…”

Section: Memorymentioning

confidence: 99%

Electrophysiological and information processing variability predicts memory decrements associated with normal age-related cognitive decline and Alzheimer's disease (AD)

et al. 2006

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“…The latter group shows only the delay in latency associated with normal aging (Brown et al, 1982;Patterson et al, 1988). Discrimination between patients with early Alzheimer's disease and healthy individuals has also been reported (Holt et al, 1995;Polich et al, 1990a), with simple tasks yielding the largest P300 difference between groups (Polich and Corey-Bloom, 2005).…”

Section: Dementiamentioning

confidence: 99%

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

Duncan

Barry

Connolly

et al. 2009

Clinical Neurophysiology

993

845

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“…Squires et al 1980), Alzheimer's disease and Korsakoff's syndrome (Pfefferbaum et al 1984;St. Clair et al 1985;Patterson et al 1988), mild arteriosclerotic dementia (Leppler and Greenberg 1984) and in a group of patients with a specific disorder of auditory short-term memory (Starr and Barrett 1987), suggests that the memory aspects of the target-detection task may not be the major cognitive attribute contributing to the resuiting parietal positivity (P300). A comparison of P3 in the 'odd-ball' task with the sustained positivity that accompanied memory scanning in this study reveals several differences.…”

Section: Auditory Digitsmentioning

confidence: 99%

Brain potentials in a memory-scanning task. I. Modality and task effects on potentials to the probes

Pratt

Michalewski

Barrett

et al. 1989

Electroencephalography and Clinical Neurophysiology

Self Cite

102

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SummaryEvent-related potentials were measured in normal young subjects during a memory-scanning paradigm modified from one proposed by Sternberg. The stimuli used were verbal (digits) and non-verbal (musical notes) with the verbal stimuli and notes presented acoustically and the verbal stimuli also presented visually. In this paradigm each set of stimuli was presented for memorization, and then, after a 2 sec interval, a probe item appeared and was identified by the subject as belonging or not belonging to the memorized set. Memorized set sizes of 1, 3 and 5 items were studied. The potentials are described in terms of scalp distribution, latency and amplitude, and are compared with behavioral descriptors of performance (accuracy and reaction time). These potentials are also compared with those evoked by an auditory target-detection task ('odd-ball' paradigm) in the same subject at the same session.The potentials evoked by the probe stimuli consisted of a positive (P50-90), negative (N100-150), positive (P185-225) sequence in the first 250 msec, followed by a later, long-lasting (approximately 700 msec) positive component (labeled P3). This positivity consisted of an earlier component (latency of approximately 350-400 msec) with a frontal distribution, followed by a larger and later parietal component. The amplitude of the frontal component and the latency of the parietal component varied with the number of items in the memorized set differently from behavioral reaction times. Stimulus modality also affected both the amplitude and latency of the sustained parietal positive potential. Memory processes associated with the P3 complex in the 'odd-ball' task and the long-lasting positivity in the memory-scanning task are discussed.Key words: Event-related potentials; Memory scanning; Stimulus modality; Task effect The P300 (or P3) component of event-related potentials, evoked by the detection of a rare target stimulus (the so-called 'odd-ball' paradigm), is considered endogenous, reflecting cognitive processes such as stimulus evaluation and, in particular, aspects of memory function involved in 'mem-

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Latency variability of the components of auditory event-related potentials to infrequent stimuli in aging, Alzheimer-type dementia, and depression

Cited by 168 publications

References 28 publications

Electrophysiological and information processing variability predicts memory decrements associated with normal age-related cognitive decline and Alzheimer's disease (AD)

Electrophysiological and information processing variability predicts memory decrements associated with normal age-related cognitive decline and Alzheimer's disease (AD)

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

Brain potentials in a memory-scanning task. I. Modality and task effects on potentials to the probes

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