Late systolic indices of ventricular function: Noninvasive derivation in congestive heart failure

Binkley, Philip F.; Lewe, Robert F.; Unverferth, Donald V.; Leier, Carl V.

doi:10.1016/0002-8703(88)90451-6

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Serial measurements of elas tance with this noninvasive method may be useful, and an alternative to échocardiographie techniques [5,6], for monitoring change in cardiac contractile performance in patients with systolic dysfunction.…”

Section: Limitationsmentioning

confidence: 99%

“…Less loaddependent indices of contractility include systolic elas tance, preload recruitable stroke work, or the dp/dtmaxend diastolic volume (EDV) relationship [4], but invasive procedures are usually required to obtain the data neces sary for these measurements, so their utilization for serial evaluations in cardiac patients is limited. Indices of sys tolic function determined by échocardiographie tech niques such as the left ventricular end-systolic wall stressvelocity of fiber shortening relationship have been used to measure contractility noninvasively [5,6], However, this method is limited to individuals in whom a technically adequate echocardiogram is obtainable and by the need to define the relationship in a control group at variable end systolic wall stresses.…”

Section: Introductionmentioning

confidence: 99%

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End Ejection Elastance Determined from Radionuclide Ventriculography and Carotid Pulse Records as an Index of Left Ventricular Contractility

Papadakos¹,

Hager²,

Karimeddini³

et al. 1994

Am J Noninvas Cardiol

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The objective of this study was to assess the ability of a noninvasive radionuclide method to measure left ventricular systolic elastance as an index of left ventricular contractility in normal individuals. End systolic and peak systolic elastance are considered load-independent indices of contractility. Since invasive procedures are usually required for these measurements, their utilization for serial evaluations in cardiac patients is not practical. A noninvasive technique to measure contractility utilizing radionuclide ventriculography would, therefore, be useful. End-ejection elastance was calculated in 10 normal subjects from simultaneous cuff blood pressure, carotid pulse waveform and radionuclide ventriculogram measurements at baseline and during dobutamine infusion. End ejection pressure was measured by linear interpolation of the carotid pulse waveform. End ejection volume was calculated from end diastolic volume and ejection fraction. Loading conditions were altered with nitroprusside and phenylephrine and elastance was estimated as the slope of the end ejection pressure-volume relationship for each inotropic state using linear regression. Under control conditions, end ejection elastance could be determined with this noninvasive technique in all the normal subjects and was 1.49 ± 0.27 mm Hg/ml. During dobutamine infusion end ejection elastance was 3.14 ± 1.45 in the 7 subjects in whom it could be measured (p = 0.003). In the 7 subjects with paired data end-ejection elastance increased from 1.42 ± 0.19 to3.14 ± 1.45 (p = 0.022) during dobutamine infusion. Of the 17 end ejection elastance determinations, 15 were estimated from three or more loading conditions. The correlation coefficient of the linear regression analysis from which elastance was estimated was >0.87 in 12 of these 15 determinations. End-ejection elastance measured noninvasively utilizing only radionuclide ventriculography and carotid wave pulse tracings can serve as an index of left ventricular contractility.

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Section: Limitationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

End Ejection Elastance Determined from Radionuclide Ventriculography and Carotid Pulse Records as an Index of Left Ventricular Contractility

Papadakos¹,

Hager²,

Karimeddini³

et al. 1994

Am J Noninvas Cardiol

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Ability of left ventricular stress-shortening relations, end-systolic stress/volume ratio and indirect indexes to detect severe contractile failure in ischemic or idiopathic dilated cardiomyopathy

Roman¹,

Devereux²,

Cody³

1989

The American Journal of Cardiology

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Comparison of Noninvasive Measures of Contractility in Dilated Cardiomyopathy

Roman

Devereux

1991

Echocardiography

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Left ventricular performance is usually quantified by ejection phase indices such as ejection fraction, cardiac output, and fractional shortening. The load-dependence of these measures may result in inaccurate estimation of intrinsic myocardial contractility in states of chronic pressure or volume overload. End-systolic and stress-shortening relations have been proposed as measures of contractile state insofar as they are theoretically independent of preload and incorporate afterload. This article examines the behavior of these relations in response to changes in loading conditions and contractile state and reviews their application utilizing noninvasive methodology, particularly in the setting of dilated cardiomyopathy.

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Late systolic indices of ventricular function: Noninvasive derivation in congestive heart failure

Cited by 3 publications

References 22 publications

End Ejection Elastance Determined from Radionuclide Ventriculography and Carotid Pulse Records as an Index of Left Ventricular Contractility

End Ejection Elastance Determined from Radionuclide Ventriculography and Carotid Pulse Records as an Index of Left Ventricular Contractility

Ability of left ventricular stress-shortening relations, end-systolic stress/volume ratio and indirect indexes to detect severe contractile failure in ischemic or idiopathic dilated cardiomyopathy

Comparison of Noninvasive Measures of Contractility in Dilated Cardiomyopathy

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