Late Side Effects of Chemotherapy and Radiotherapy in Early Childhood on the Teeth: Two Case Reports

Yılmaz, Sevcihan Günen; Bayrakdar, İ̇brahim Şevki; Bayrak, Seval; Yaşa, Yasin

doi:10.4274/tjh.2017.0216

Cited by 6 publications

(3 citation statements)

References 7 publications

(10 reference statements)

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“…Several dental anomalies resulting from radio and chemotherapy treatment have been reported in the literature, including taurodontia, hypodontia, enamel hypoplasia and radicular hypoplasia. In this sense, it is known that the more intense the antineoplastic treatment, the greater the presence of anomalies present in the oral cavity of these patients 1,2,3 .…”

Section: Introductionmentioning

confidence: 99%

How radio and chemotherapy can affect the development of the teeth

Rio¹,

Rodrigues²,

Lyra³

et al. 2024

J Oral Diag

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Introduction:The evolution of chemo and radiotherapy, added to the increased frequency in its use, have led to an increase in the survival rate of pediatric patients with head and neck cancer. Thus, the effects of this therapy are increasingly common, and may affect even the teeth in formation. Objective: Conduct a literature review on the main dental anomalies of development in patients undergoing chemo and radiotherapy. Material and methods: The databases "Pubmed", "Google Scholar" and "Science Direct" were consulted using the keywords "dental alterations", "children", "dentistry", "cancer", "chemotherapy" and " radiotherapy". Twenty-seven articles published in English were selected. Results:Based on the articles included in the study, the effects of chemoradiotherapy on developing teeth can be both quantitative and qualitative. Those patients who underwent treatment during childhood, in this literature review, were between 0.8 and 15 years old. The main dental anomalies found include microdontia, hypodontia and root anomalies. In addition, it was also observed that the late effects of the therapy vary according to the radiation dose and the chemotherapy dose. Conclusions: Although there are few studies on dental alterations caused by chemotherapy and radiotherapy, it is necessary to implement protocols aimed at oral care during and after treatment to reduce the incidence and severity of such complications.

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Section: Introductionmentioning

confidence: 99%

How radio and chemotherapy can affect the development of the teeth

Rio¹,

Rodrigues²,

Lyra³

et al. 2024

J Oral Diag

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“…Essas drogas não se restringem apenas às células tumorais, mas sim a todas as células em multiplicação, provocando efeitos colaterais agudos como mucosite oral, alopecia, neutropenia e infecções oportunistas (Figliolia et al, 2008;Muniz et al, 2021). Pacientes pediátricos além dos efeitos agudos, também estão sujeitos a desenvolverem alterações tardias em estruturas que estiverem em formação (Günen Yılmaz et al, 2018;Proc et al, 2021). Uma recente revisão de literatura incluiu artigos publicados que relataram os principais efeitos agudos e tardios do tratamento oncológico.…”

Section: Introductionunclassified

“…Agenesia dentária é a segunda alteração mais frequente (Owosho et al, 2016). A ocorrência e gravidade desses efeitos dependem de fatores de risco como a idade no diagnóstico, tipo e duração do tratamento, campo de radiação e a dose recebida (Günen Yılmaz et al, 2018).…”

Section: Introductionunclassified

Late dental effects of chemotherapy and radiotherapy in childhood cancer survivor: case report

Miranda¹,

Miranda²,

Henriques³

et al. 2021

RSD

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Chemotherapy drugs and radiotherapy in the head and neck region are considered possible to interfere with odontogenesis. Patients may present alterations such as tooth agenesis, shortening or root malformation, enamel hypoplasia and microdontia. Such effects do not occur in adults, as they already have the dental structures formed. The objective of this study is to describe, through a case report, the dental alterations and implications for the clinical practice of a patient who received chemotherapy and radiotherapy in childhood. A 12- year-old female patient was diagnosed with embryonal rhabdomyosarcoma in the right parotid gland region at 5 years of age. Antineoplastic treatment consisted of IRS IV chemotherapy protocol: ifosfamide (IFO) - doxorubicin (DOXO) - etoposide (VP16) followed by vincristine - dactinomycin - cyclophosphamide (VAC) / vincristine - ifosfamide - etoposide (VIE) alternated, in addition to conventional radiotherapy, with a total dose of 45 Gy. The patient developed important dental alterations, such as root malformation in most teeth, microdontia and enamel hypoplasia, being essential the role of the dentist. Currently, after 6 years of anticancer treatment, she has regular dental follow-up.

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Antineoplastics

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Late Side Effects of Chemotherapy and Radiotherapy in Early Childhood on the Teeth: Two Case Reports

Cited by 6 publications

References 7 publications

How radio and chemotherapy can affect the development of the teeth

How radio and chemotherapy can affect the development of the teeth

Late dental effects of chemotherapy and radiotherapy in childhood cancer survivor: case report

Antineoplastics

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