Late Progression of Tricuspid Regurgitation After Transcatheter Aortic Valve Replacement

Muraishi, Makio; Tabata, Minoru; Shibayama, Kentaro; Ito, Joji; Shigetomi, Kyoko; Obunai, Kotaro; Watanabe, Hiroyuki; Yamamoto, Masanori; Watanabe, Yusuke; Naganuma, Toru; Shirai, Shinichi; Yamawaki, Masahiro; Tada, Norio; Yamanaka, Futoshi; Mizutani, Kazuki; Ueno, Hiroshi; Takagi, Kensuke; Yashima, Fumiaki; Hayashida, Kentaro

doi:10.1016/j.jscai.2022.100043

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…In our analysis, baseline moderate to severe TR was associated with 2-folds higher mortality at 1-year follow up post TAVI procedure. In other analysis, progression of mild or less to moderate or higher TR post TAVI was also associated with higher mortality at 2-year follow-up, likely related to worsening RV function and pulmonary hypertension (18). In addition, previous meta- analyses had linked significant TR, RV dysfunction, and pulmonary hypertension with higher mortality and worse prognosis post TAVI (19,20).…”

Section: Discussionmentioning

confidence: 96%

Impact of Moderate to Severe Mitral and Tricuspid Valves Regurgitation after Transcatheter Aortic Valve Implantation: A Multicenter Retrospective Study

Abraham,

Botros,

Fath

et al. 2024

Preprint

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Tricuspid regurgitation (TR) and mitral regurgitation (MR) are common valvular conditions encountered in patients undergoing transcatheter aortic valve implantation (TAVI). This retrospective study investigates the impact of moderate or severe TR and MR on all-cause mortality in one-year post-TAVI patients. Consecutive patients who underwent TAVI at our institution between 2012 and 2018 were identified. Patients were stratified into 2 groups based on valvular regurgitation severity: moderate/severe MR vs. no/mild MR, and moderate/severe TR vs. no/mild TR. Primary outcome was all-cause mortality at 1-year follow up, and secondary outcome was in-hospital death. Logistic regression analysis was conducted to assess the relationship between moderate/severe MR or TR and all-cause mortality at 1-year follow-up. We included a total of 1,071 patients who underwent TAVI with mean age 80.9 ± 8.6 years, 97% white, and 58.3% males. Moderate or severe MR group included 52 (4.88%) patients while mild or no MR group included 1,015 (95.12%) patients. There was no significant difference between both groups in TAVI procedure success rate (100% vs. 97.83%, p=0.283), in-hospital mortality (0 vs. 1.08%, p=0.450), or mortality at 1-year follow up (15.38% vs. 14.09%, p=0.794). In the logistic regression analysis, moderate or severe MR did not show significant correlation with all-cause mortality at 1-year follow up (OR 0.88, 95% CI [0.38 - 1.99], p=0.761). Moderate or severe TR group included 86 (8.03%) patients while mild or no TR group included 985 (91.97%) patients. There was no difference between both groups in TAVI procedure success (98.8% vs. 97.9%, p=0.54) or in-hospital mortality (0% vs. 1.1%, p=0.33). At 1-year follow up, patients with moderate or severe TR had higher mortality (26.7% vs. 13.2%, p=0.001) compared to patients with mild or no TR. In the logistic regression analysis, moderate or severe TR was correlated with higher all-cause mortality at 1-year (OR 1.89, 95% CI [1.07, 3.34], P=0.027). At 1 year follow up, moderate/severe TR, but not MR, is associated with higher mortality in patients underwent TAVI. Careful assessment of multi-valvular heart disease prior to the procedure is warranted.

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Section: Discussionmentioning

confidence: 96%

Impact of Moderate to Severe Mitral and Tricuspid Valves Regurgitation after Transcatheter Aortic Valve Implantation: A Multicenter Retrospective Study

Abraham,

Botros,

Fath

et al. 2024

Preprint

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“…In the PARTNER II trial cohort B, among one-year survivors with nonsignificant TR at baseline, 19% had progression to significant TR [ 55 ]. Muraishi et al showed a TR worsening from baseline mild or less TR to a moderate or severe grade in 87 patients (5.4%) with 3 independent predictors of TR progression: atrial fibrillation, transaortic mean pressure gradient < 40 mmHg on pre-TAVI TTE, and PASP > 40 mmHg [ 68 ].…”

Section: Tavi and Right Heartmentioning

confidence: 99%

Echocardiographic Evaluation after Transcatheter Aortic Valve Implantation: A Comprehensive Review

Angellotti

Manzo

Castiello

et al. 2023

Life

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Transcatheter aortic valve implantation (TAVI) is an increasingly popular treatment option for patients with severe aortic stenosis. Recent advancements in technology and imaging tools have significantly contributed to the success of TAVI procedures. Echocardiography plays a pivotal role in the evaluation of TAVI patients, both before and after the procedure. This review aims to provide an overview of the most recent technical advancements in echocardiography and their use in the follow-up of TAVI patients. In particular, the focus will be on the examination of the influence of TAVI on left and right ventricular function, which is frequently accompanied by other structural and functional alterations. Echocardiography has proven to be key also in detecting valve deterioration during extended follow-up. This review will provide valuable insights into the technical advancements in echocardiography and their role in the follow-up of TAVI patients.

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Functional Tricuspid Regurgitation in the Transcatheter Aortic Valve Replacement Population and Emerging Transcatheter Tricuspid Valve Interventions

Silkowski,

Kendsersky,

Amoroso

2024

US Cardiol

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Transcatheter aortic valve replacement (TAVR) has revolutionized the management of aortic valve disease. However, its success has brought attention to concurrent tricuspid valve disease and the inadequacy of treatments. This review explores the emerging field of transcatheter tricuspid valve interventions (TTVI) after TAVR. We address the pathophysiology and prevalence of post-TAVR tricuspid valve disease and TTVI strategies, including repair, replacement, annuloplasty, and edge-to-edge repair. We also discuss clinical studies assessing TTVI safety and efficacy, including for patients with previous TAVR. Collaboration among clinical disciplines remains crucial for advancing this emerging field to establish best practices regarding patient selection and procedural complexities.

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Late Progression of Tricuspid Regurgitation After Transcatheter Aortic Valve Replacement

Cited by 3 publications

References 28 publications

Impact of Moderate to Severe Mitral and Tricuspid Valves Regurgitation after Transcatheter Aortic Valve Implantation: A Multicenter Retrospective Study

Impact of Moderate to Severe Mitral and Tricuspid Valves Regurgitation after Transcatheter Aortic Valve Implantation: A Multicenter Retrospective Study

Echocardiographic Evaluation after Transcatheter Aortic Valve Implantation: A Comprehensive Review

Functional Tricuspid Regurgitation in the Transcatheter Aortic Valve Replacement Population and Emerging Transcatheter Tricuspid Valve Interventions

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