A 71-year-old woman, with a history of non-small cell lung cancer (NSCLC) with subsequent pneumonectomy presented with worsening dyspnea on exertion and non-productive cough.The patient first noted the shortness of breath and cough 4 weeks prior to presentation, which were refractory to albuterol nebulization. The patient also reported a 6 lb. weight loss during this time period. She denied fevers, chills, night sweats or chest pain. The patient was diagnosed with NSCLC 11 years ago and underwent a right-sided extrapleural pneumonectomy at that time. She received no radiation or chemotherapy. She did not require home oxygen and reported a generally good functional status prior to the development of her latest symptoms. Other past medical history included hyperlipidemia. The patient had been smoking a pack of cigarettes per day for the past 35 years, but denied alcohol or illicit drug use. Current medications included albuterol nebulizer, aspirin, alprazolam, levothyroxine, simvastatin, and over-the-counter Excedrin (acetaminophen, aspirin, caffeine).On examination, the patient appeared in minimal respiratory distress. She was afebrile, blood pressure was 110/60 mm Hg, the pulse 97 beats per minute, the respiratory rate 16 breaths per minute, and the oxygen saturation 95% on ambient air. Her heart exam had no murmurs, rubs, or gallops. There were coarse breath sounds over the lower field of the left lung and decreased breath sounds with egophony at the right base. There was no lower extremity edema or calf tenderness. White blood cell count was within normal limits without a bandemia. Chest radiography revealed opacification of the right hemithorax with overall volume loss and left-to-right mediastinal and tracheal shift in keeping with prior right pneumonectomy. There were several surgical clips seen in the right hemithorax. The left lung field was unremarkable without pneumothorax, pleural effusion, pulmonary edema or focal consolidation. The cardiomediastinal silhouette evaluation was severely limited due to significant left-to-right mediastinal shift. The chest radiograph was interpreted by radiology as "stable post-pneumonectomy changes with no effusions, edema or consolidation." A computed tomography scan was revealed hilar adenopathy with mass effect as well as a new 3 mm nodule in the left lower lobe.