Late magnetic resonance imaging features of leukoencephalopathy in children with central nervous system tumours following high-dose methotrexate and neuraxis radiation therapy

Kellie, Stewart J.; Chaku, Jyoti; Lockwood, Liane; O'Regan, Peter; Waters, Keith; Wong, C K F

doi:10.1016/j.ejca.2005.02.024

Cited by 22 publications

(20 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4-7 The differences in time course may be related to the use of PT, the induction or maintenance chemotherapy regimen, the age of the patients included in our series 8,9 or other factors coincident with the performance of the protocol including surgical sequelae. 10-12 …”

Section: Discussionmentioning

confidence: 99%

Imaging Changes in Very Young Children with Brain Tumors Treated with Proton Therapy and Chemotherapy

Sabin¹,

Merchant²,

Harreld³

et al. 2012

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

PT promises to reduce side effects in children with brain tumors by sparing normal tissue when compared to 3-dimensional conformal or intensity-modulated radiation therapy. Information is lacking about the combined effects of PT and chemotherapy in young children. We describe imaging changes in eight very young children with localized brain tumors who received PT after chemotherapy. Mostly transient signal abnormalities and enhancement in brain parenchyma were observed by serial MR imaging that were consistent with radiation-induced effects on normal appearing tissue. Correlation with PT planning data revealed that the areas of imaging abnormality were located within or adjacent to the volume that received the highest radiation dose. Radiologists should be aware of these findings in children who receive PT after chemotherapy. In this report we describe the time course of these PT-related imaging findings and correlate with treatment and clinical outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Imaging Changes in Very Young Children with Brain Tumors Treated with Proton Therapy and Chemotherapy

Sabin¹,

Merchant²,

Harreld³

et al. 2012

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…The cerebellar parts of these circuits may be damaged by the tumor and by surgery, possibly leading to a supratentorial axonal degeneration and thereby to a decrease of FA, especially in the frontal and parietal white matter (Fig. 2, slices [6][7][8][9][10][11][12][13][14][15][16][17][18][19]. This process might possibly be similar to the pathomechanism that underlies the finding of a synapses-mediated axonal atrophy in newborn infants with cerebellar hemorrhage leading to a loss of volume and function of the contralateral supratentorial counterpart (27).…”

Section: Pa Patientsmentioning

confidence: 99%

“…For diagnostic purposes conventional imaging included axial T2-weighted fast spin-echo sequences (TR/TE, 4,000 ms/100 ms; 3 mm-sections; in-plane resolution of 0.4 mm Â 0.8 mm) and T1-weighted inversion-recovery fast spin-echo sequences (TR/TE, 2,000 ms/15 ms; inversion time, 860 ms; 5-mm sections; in-plane resolution of 0.4 mm Â 0.8 mm). T2-weighted images were used to assess the severity of white matter changes and atrophy and to rate leukoencephalopathy (18).…”

Section: Data Acquisitionmentioning

confidence: 99%

Differences in Supratentorial Damage of White Matter in Pediatric Survivors of Posterior Fossa Tumors With and Without Adjuvant Treatment as Detected by Magnetic Resonance Diffusion Tensor Imaging

Rueckriegel

Driever

Blankenburg

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

“…Late adverse effects of radiotherapy to the central nervous system (CNS) may develop after a latency period of several years [14,15].There is considerable late morbidity and mortality among brain tumour patients [16,17]. Survivors of childhood leukemia have an increased risk of late effects which are more common following treatment given at young age and when radiotherapy is included [13,18,19].…”

mentioning

confidence: 99%

Prevalence of Norwegian patients diagnosed with childhood cancer, their working ability and need of health insurance benefits

et al. 2007

View full text Add to dashboard Cite

The object of this study was in a population-based material to investigate the prevalence of patients diagnosed with childhood cancer, and compared to the general population to assess working ability, yearly income and need for health insurance benefits in patients surviving at least five years after treatment for childhood CNS tumours or hematological malignancies. During the period January 1, 1970 to December 31, 2002 the prevalence in the Norwegian population of patients diagnosed with any childhood cancer increased from 12.2 (473/3 888 305) to 65.1 (2944/4 524 066) per 100 000 population. The proportion of survivors in need of any health insurance benefit was for CNS tumours 47.1% and for hematological malignancies 21.0%. The proportion in the age group 16-67 receiving disability pension for CNS tumours was 94/454 (20.7%) compared to 21/575 (3.7%) for patients treated for hematological malignancies (p < 0.001). Of patients given radiotherapy 25/70 (35.7%) received disability pension, compared to 90/959 (9.4%) in unirradiated patients, p < 0.001. Yearly income and working ability was particularly low for CNS tumour survivors. This study illustrates loss of working capability associated with pediatric cancer and treatment and long-term requirement of health insurance benefits.

show abstract

Late magnetic resonance imaging features of leukoencephalopathy in children with central nervous system tumours following high-dose methotrexate and neuraxis radiation therapy

Cited by 22 publications

References 37 publications

Imaging Changes in Very Young Children with Brain Tumors Treated with Proton Therapy and Chemotherapy

Imaging Changes in Very Young Children with Brain Tumors Treated with Proton Therapy and Chemotherapy

Differences in Supratentorial Damage of White Matter in Pediatric Survivors of Posterior Fossa Tumors With and Without Adjuvant Treatment as Detected by Magnetic Resonance Diffusion Tensor Imaging

Prevalence of Norwegian patients diagnosed with childhood cancer, their working ability and need of health insurance benefits

Contact Info

Product

Resources

About