Late-life depression and mortality: influence of gender and
                        antidepressant use

Ryan, Joanne; Carrière, Isabelle; Ritchie, Karen; Stewart, Robert; Toulemonde, Gwladys; Dartigues, Jean François; Tzourio, Christophe; Ancelin, Marie-Laure

doi:10.1192/bjp.bp.107.039164

Cited by 87 publications

(80 citation statements)

References 28 publications

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“…In men with Severe DS, we did not observe a significant association with any of the disability measures after 7 years of follow-up, probably due to lower number (4.9% compared to 12.2% for women) and a higher mortality rate. Indeed in the same cohort, an increase in depression-related 4-year mortality risk was observed in men with mild (OR=2.8) and treated severe DS (OR=5.3) whereas in women only non-treated severe DS which slightly increased risk (OR=1.8) (Ryan et al, 2008). Several previous studies have reported an increase in activity limitations (most frequently severe ADL limitations) associated with DS in elderly community cohorts (see (Carriere et al, 2009;Schillerstrom et al, 2008), for reviews).…”

Section: Gender Differences In Depression-related Activity Limitationmentioning

confidence: 80%

“…Severity of depressive symptoms was assessed using the 20-item Center for Epidemiologic Studies-Depression scale (CES-D) (Radloff, 1977). For this analysis, participants were classified into one of three groups (Ryan et al, 2008). 'Severe depressive symptomatology' (Severe DS group) included participants with a current MDE or a CES-D score of 23 or over (allowing for the fact that some participants with severe symptoms did not reach DSM classification criteria, principally because of the duration of symptoms).…”

Section: Depressionmentioning

confidence: 99%

“…Furthermore, although gender differences have been consistently observed in the aetiology and clinical presentation of depression, differential susceptibility to depression-related disability has surprisingly seldom been investigated. We recently reported that the association between depression and 4-year mortality is dependent both on gender and disease severity, the greatest risk being observed for men with severe depression (Ryan et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Late life depression and incident activity limitations: Influence of gender and symptom severity

Carrière

Gutierrez

Pérès

et al. 2011

Journal of Affective Disorders

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Section: Gender Differences In Depression-related Activity Limitationmentioning

confidence: 80%

Section: Depressionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Late life depression and incident activity limitations: Influence of gender and symptom severity

Carrière

Gutierrez

Pérès

et al. 2011

Journal of Affective Disorders

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“…Because the exact pathways leading from depression to increased mortality are not yet known, a broad range of differential pathways between men and women may explain these differences (Penninx et al, 1999;Ryan et al, 2008). For example, the physiological and behavioral reactions to stress of women may differ from those of men (Penninx et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Is excess mortality higher in depressed men than in depressed women? A meta-analytic comparison

Cuijpers¹,

Vogelzangs²,

Twisk³

et al. 2014

Journal of Affective Disorders

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a b s t r a c tBackground: It is not well-established whether excess mortality associated with depression is higher in men than in women. Methods: We conducted a meta-analysis of prospective studies in which depression was measured at baseline, where mortality rates were reported at follow-up, and in which separate mortality rates for men and women were reported. We conducted systematic searches in bibliographical databases and calculated relative risks of excess mortality in men and women. Results: Thirteen studies were included. Among the people with depression, excess mortality in men was higher than in women (RR¼1.97; 1.63-2.37). Compared with non-depressed participants, excess mortality was increased in depressed women (RR¼ 1.55; 95% CI: 1.32-1.82), but not as much as in men (RR¼ 2.04; 95% CI: 1.76-2.37), and the difference between excess mortality in men was significantly higher than in women (p o0.05). Conclusions: Excess mortality related to depression is higher in men than in women. Although the exact mechanisms for this difference are not clear, it may point at differential or more intensified pathways leading from depression to increased mortality in depressed men compared to women.

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“…Here, the exclusion of participants who committed suicide from the analyses did not change the results (data not shown). Moreover, a number of studies have reported an increased risk of mortality in depressed men, but not in women [19,20]. A meta-analysis including studies with random samples from different communities found that the relative mortality risk for depressed men was only non-significantly higher than for depressed women [11].…”

Section: Discussionmentioning

confidence: 99%

Purchase of antidepressant agents by patients with type 1 diabetes is associated with increased mortality rates in women but not in men

et al. 2011

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Aims/hypothesis Individuals with diabetes have increased mortality rates compared with the general population. In patients with type 2 diabetes depression further contributes to the increased mortality. Depression and mortality rates in patients with type 1 diabetes are an understudied phenomenon. We therefore studied their association in a prospective setting. Methods We followed 4,174 participants (51% men, age 39±12 years, diabetes duration 22±12 years [mean± SD]) in the Finnish Diabetic Nephropathy Study (FinnDiane) for an average of 9 years. Depression was defined as purchase of antidepressant agents at baseline and during follow-up. These data were obtained from the Finnish Drug Prescription Register. Data on allcause mortality and cause of death were obtained from the Finnish Cause of Death Register. Results At baseline, 313 (7.5%) patients had purchased antidepressant agents. During follow-up 758 (18.2%) additional cases were observed. Purchasers of antidepressant agents at baseline had the highest 10-year cumulative mortality rate (22.5% [95% CI 18.1, 26.6]), followed by those with such purchases during follow-up (18.0% [15.4, 20.5]) and those with no purchases (10.1% [9.0, 11.2], p<0.001). In the adjusted Cox regression models (age, diabetes duration, diastolic blood pressure, smoking, HbA 1c and nephropathy), the purchase of antidepressant agents at baseline was associated with mortality in women, but not in men. Cardiovascular diseases were the major cause of death in non-purchasers of antidepressant agents. In antidepressant purchasers, chronic diabetic complications were the most frequent underlying cause of death. Conclusions/interpretation In a population of patients with type 1 diabetes, purchase of antidepressant agents was associated with increased mortality rates in women, but not in men.

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Late-life depression and mortality: influence of gender and antidepressant use

Abstract: The association between depression and mortality is gender-dependent and varies according to symptom load and antidepressant use.

Cited by 87 publications

References 28 publications

Late life depression and incident activity limitations: Influence of gender and symptom severity

Late life depression and incident activity limitations: Influence of gender and symptom severity

Is excess mortality higher in depressed men than in depressed women? A meta-analytic comparison

Purchase of antidepressant agents by patients with type 1 diabetes is associated with increased mortality rates in women but not in men

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