Late irradiation damage to the skin caused by soft X-ray radiation therapy of cutaneous tumors

Landthaler, M.

doi:10.1001/archderm.131.2.182

Cited by 12 publications

(10 citation statements)

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“…Does this result in a higher frequency of ulcerations in the irradiated fields during the follow up period? The ulceration frequency reported in previous studies ranges from 0.35% to 9.4% 1,12,15,29,30,51 ; we observed an ulceration frequency of 6.3%. In our study 77.5% of the ulcerations could be permanently cured by ointments and moist compresses or they healed spontaneously.…”

Section: Discussionsupporting

confidence: 49%

Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas

Schulte¹,

Lippold²,

Auras³

et al. 2005

Journal of the American Academy of Dermatology

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Section: Discussionsupporting

confidence: 49%

Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas

Schulte¹,

Lippold²,

Auras³

et al. 2005

Journal of the American Academy of Dermatology

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“…Introduction of sophisticated surgical methods and increased public awareness of radiation toxicity have resulted in limited use of radiation therapy by dermatologists. Although side‐effects from high doses used decades ago are no longer a problem, anecdotal knowledge of patients with atrophic scars, ulcers, or even carcinomas 6 secondary to radiotherapy persist in the minds of dermatologists. Legal regulations and the high start‐up cost of radiation devices discourage new installations of radiation therapy equipment in offices 7 .…”

Section: Introductionmentioning

confidence: 99%

Office‐based radiation therapy for cutaneous carcinoma: Evaluation of 710 treatments

et al. 2007

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Skin cancers are the most common malignancies and, historically, ionizing radiation has played an important role in their treatment. However, less experienced dermatologists generally consider radiation last in the line of therapeutic options. The authors sought to evaluate the effectiveness and safety of office-based elective radiation therapy for cutaneous carcinoma. A retrospective study of 604 basal cell carcinomas (BCCs) and 106 squamous cell carcinomas (SCCs) irradiated between 1971-96 was performed. The percentage of patients who developed tumor recurrence during the follow-up period was calculated using Kaplan-Meier survival curves. Cox's proportional model was used to assess the prognostic factors that might have influenced the recurrences. The recurrence rates for BCC and SCC were 11.5 and 16.5 per 1000 patient-years, respectively. The 5-year cure rates were 94.4% for BCC and 92.7% for SCC, and the 15-year cure rates were 84.8% and 78.6%, respectively. Tumor location on the nasolabial fold (OR 4.4; 95% IC, 1.3-14.7) and tumor size > or = 10 mm (OR 2.14; 95% IC, 1.03-4.45) were independent predictors of BCC recurrence. This study suggested that radiation therapy is an effective treatment for BCC and SCC and should be considered as a first option in many cases.

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“…According to previous studies the risk of developing skin cancer is clearly related to the total dose applied showing that cumulative doses up to 30 Gy have a very low risk for neoplasia . Cases of skin cancer in the treated area after radiotherapy of M. Dupuytren have not been published yet, even if this treatment is performed since decades.…”

Section: Discussionmentioning

confidence: 99%