Late effects of radiotherapy on taste and salivary function in man

Mossman, Kenneth L.; Shatzman, Allan R.; Chencharick, Judith D.

doi:10.1016/0360-3016(81)90638-6

Cited by 2 publications

(7 citation statements)

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“…There is a consensus that changes in the salivary flow will happen when salivary glands receive more than 50 Gy of radiation, and below that, they can be transitory and limited [7]. Xerostomia is commonly reported by patients after the first week of RT, and an increase in its severity is observed along the weeks of RT [8]. The sensation of dry mouth may extend for long periods after the end of RT [9].…”

Section: Introductionmentioning

confidence: 99%

Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia

Palmieri

Ornaghi

Martins

et al. 2018

Journal of Oral Microbiology

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Background: Xerostomia is a very relevant and frequent complication of radiotherapy, causing the irradiated oral mucosa to be affected by bacterial, fungal and viral infections. Objective: The objective of this study was to evaluate a possible relationship between oral shedding of human herpesviruses and xerostomia in patients with squamous cell carcinoma of head and neck submitted to radio/chemotherapy. Methods: In this study, oral rinse samples were collected weekly from 20 patients during radiotherapy. The samples were submitted to PCR and enzymatic digestion for detection of human herpesviruses. Xerostomia was evaluated according to the Seminars in Radiation Oncology criteria. Results: There was a higher frequency of grade 1 xerostomia (51.4%), observed first in the 1st week of radiotherapy. In the 4th week of radiotherapy, all patients presented some degree of xerostomia. Analysis of herpesviruses showed oral shedding of EBV, HHV-6 and HHV-7 in all weeks. Considering all the periods, the highest frequency was in patients with EBV excretion (55.0%), which was significantly higher than that of other viruses. Conclusion: We observed that oral shedding of herpesviruses was not affected by xerostomia as there was a progression in their excretion, even with the evolution of xerostomia. This suggested that there is a local replication in the oral cavity that is not completely dependent of salivary excretion.

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Section: Introductionmentioning

confidence: 99%

Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia

Palmieri

Ornaghi

Martins

et al. 2018

Journal of Oral Microbiology

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“…Few studies did not specify the test but mentioned the concentrations of the taste solutions used [ 8 , 14 ]. Some of the studies also conducted STA of taste function parallel with the objective tests performed [ 2 , 3 , 8 , 9 , 19 , 20 , 22 ]. One study used a structured questionnaire alone to analyze patient-reported outcomes (PROs) related to taste function [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

“…The cross-sectional studies included assessed different groups of patients at various time points following RT. Most of these studies did not account for individual differences in treatment protocols and taste experience [ 3 , 20 , 22 ]. These studies were with highly heterogeneous sample, which made it difficult to draw conclusions on the relationship between time and taste dysfunction [ 16 •, 19 , 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…Impairment was observed in all five tastes. Irrespective of RT to the tip of the tongue, bitter and salty tastes were found to be most severely affected while sweet taste was least affect [ 2 , 3 , 20 , 22 ]. All tastes declined at 4th to 5th week after the start of RT and improved on the 11th week [ 10 ].…”

Section: Resultsmentioning

confidence: 99%

“…Loss or alteration of taste and the associated discomfort are frequent complaints during and after RT. Although primary tumors in the head and neck region rarely directly affect the sense of taste, its alteration is frequently reported by a majority of HNC patients [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Radiation-Related Alterations of Taste Function in Patients With Head and Neck Cancer: a Systematic Review

Deshpande

Blanchard

Wang

et al. 2018

Curr. Treat. Options in Oncol.

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Opinion statementTaste sensation is vital for a healthy body as it influences our food intake, acts as a defense mechanism and elicits pleasure. Majority of the head and neck cancer (HNC) patients undergoing radiotherapy suffer from altered taste function and often complain of inability to taste their food, reduced food intake, and weakness. However, there are not many studies conducted to assess this commonly reported side effect. Furthermore, clinical research on radiotherapy-induced taste alterations has proven to be difficult, considering a lack of reliable and validated study tools for assessing objective and subjective outcomes. Developing standardized tools for assessment of taste function and conducting prospective studies in larger population of HNC is the need of the hour. Taste sensation being critically important for sustenance, we need to focus on ways to preserve it. The physical properties of proton particle enable localization of the radiation dose precisely to the tumor and minimizing the exposure of the adjacent healthy tissues. By using Intensity-Modulated Proton Therapy in HNC patients, we anticipate preserving the taste sensation by reducing the dose of radiation to the taste buds.

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Late effects of radiotherapy on taste and salivary function in man

Cited by 2 publications

References 0 publications

Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia

Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia

Radiation-Related Alterations of Taste Function in Patients With Head and Neck Cancer: a Systematic Review

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