Late Effects of Gamma Radiation on Mice protected with Cysteamine or Cystamine

Mewissen, D.J.; Brucer, Marshall

doi:10.1038/179201b0

Cited by 19 publications

(3 citation statements)

References 2 publications

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“…The data after fractionated exposure have, however, been equivocal. Thus, Doull et al (1963) and Mewissen and Brucer (1957) could not obtain protection by cysteamine with short fractionation intervals. On the other hand, Nelson et al (1969Nelson et al ( , 1971 found protection by cyteamine with fractionation intervals from 1-7 days provided the dose was neither too low nor too high.…”

Section: Resultsmentioning

confidence: 93%

“…1484 of the Euratom Biology Division contradictory (Cosgrove et al, 1964;Dacquisto and Benson, 1962;Doull et al, 1963;Holleroft et al, 1957;Maisin, 1968;Maisin et al, 1970Maisin et al, , 1971Maisin and Lambiet-Collier, 1968;Maisin et al, 1977a;Mewissen and Brucer, 1957;Nelson et al, 1963Nelson et al, , 1967Nelson et al, , 1971Upton et al, 1959;Wand and Hasegawa, 1968), and it is uncertain whether the late damage in the animals protected against the acute effects is repaired as efficiently as it is in nonprotected animals which received a lower dose corresponding to a same survival rate. In order to obtain more information on these questions -repair with respect to late effects and the effects of radioproteetors on this repair -normal and protected mice were irradiated at regular intervals until death.…”

Section: Introductionmentioning

confidence: 96%

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Repair and biochemical protection in life shortening of mice exposed to fractionated X-irradiation

Maisin

Gerber

Lambiet-Collier

et al. 1978

Radiat Environ Biophys

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Male mice of the BALB/c+ strain were exposed to X-rays at fractionation intervals of 7, 15, 30, and 60 days. One group received a mixture of radioprotectors, another AET (only 30 days fractionation), a third one served as control. The doses ranged, dependent on the treatment, from 300--1500 R. When survival was corrected for acute death, the control and AET treated animals died after an accumulated dose of about 2000 R whereas those treated with a mixture of radioprotectors died after about 4000 tr. Bone marrow failure and lung damage is the main cause of death within the initial 200 days after start of the exposure. At later times, fibrotic changes and in particular glomerulosclerosis are observed.

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Section: Resultsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 96%

Repair and biochemical protection in life shortening of mice exposed to fractionated X-irradiation

Maisin

Gerber

Lambiet-Collier

et al. 1978

Radiat Environ Biophys

View full text Add to dashboard Cite

show abstract

“…Since the protective action of MEG is believed t o be similar to that of cysteamine, it is paradoxical that the latter compound was not found t o protect C57BL mice against induction of lymphomas by y rays (11). In the latter case, however, the radiation was given in two exposures 5 days apart; hence, in view of the complex interaction between dose, time, and radiation intensity in lymphoma-induction (6,12), the dosereducing action of cysteamine and cystamine might have modified the relation between dose and interval in such a way as t o enhance, rather than reduce, the leukemogenic effectiveness of the radiation.…”

Section: Lilesults Nnd Discussionmentioning

confidence: 99%