Late effects of childhood cancer treatment in long-term survivors diagnosed before the age of 3 years – A multicenter, nationwide study

Latoch, Eryk; Zubowska, Małgorzata; Młynarski, Wojciech; Stachowicz‐Stencel, Teresa; Stefanowicz, Joanna; Sławińska, Dorota; Kowalczyk, Jerzy; Skalska‐Sadowska, Jolanta; Wachowiak, Jacek; Badowska, Wanda; Czajńska‐Deptuła, Aneta; Dembowska‐Bagińska, Bożenna; Garus, Katarzyna; Skoczeń, Szymon; Pobudejska-Pieniążek, Aneta; Szczepański, Tomasz; Machnik, Katarzyna; Panasiuk, Anna; Sęga-Pondel, Dorota; Malesza, Iwona; Raciborska, Anna; Zielezińska, Karolina; Urasiński, Tomasz; Mizia‐Malarz, Agnieszka; Wawrzeńczyk, Anna; Karolczyk, Grażyna; Kołtan, Andrzej; Wysocki, Mariusz; Wołowiec, Magdalena; Matysiak, Michał; Krawczuk‐Rybak, Maryna

doi:10.1016/j.canep.2022.102209

Cited by 3 publications

(5 citation statements)

References 38 publications

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“…12 A single-centre study from Switzerland found that 13.6% of CCS attending a follow-up care visit had a MSHC, 18 and a nationwide study from Poland found a prevalence of any MSHC of 19.2%. 17 Regarding long-term cumulative incidence of any MSHC, Bhakta and colleagues found that at the age of 50 years, 83.6% of survivors had experienced a MSHC, 13 which is higher than what we observed in our cohort. This difference may be attributed to the younger average age of our cohort.…”

Section: 8contrasting

confidence: 74%

“…The North American Childhood Cancer Survivor Study (CCSS) found that 10.4% of survivors reported prevalence of any MSHC , but they only assessed four types of MSHCs 12 . A single‐centre study from Switzerland found that 13.6% of CCS attending a follow‐up care visit had a MSHC, 18 and a nationwide study from Poland found a prevalence of any MSHC of 19.2% 17 . Regarding long‐term cumulative incidence of any MSHC, Bhakta and colleagues found that at the age of 50 years, 83.6% of survivors had experienced a MSHC, 13 which is higher than what we observed in our cohort.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies analysing MSHCs have merged them to a single outcome, disregarding distinct entities 11,13,17,18 . Only few studies have presented results stratified for specific MSHCs 10,12 .…”

Section: Introductionmentioning

confidence: 99%

“…10,11 Most studies analysing MSHCs have merged them to a single outcome, disregarding distinct entities. 11,13,17,18 Only few studies have presented results stratified for specific MSHCs. 10,12 Other studies have determined incidence or prevalence of specific MSHCs, but in selected diagnostic groups only.…”

Section: Introductionmentioning

confidence: 99%

“…16 Prevalence of MSHC in cohorts of CCS varies from 2% to 62% depending on the definition of MSHCs and the average age of the cohort. 11,12,[17][18][19][20] Incidence of MSHCs is largest in the first years after diagnosis, but evidence suggests that MSHCs can also develop decades after diagnosis, 10 although there are differences by primary cancer diagnosis. 21 All treatment modalities used for treating children and adolescents with cancer can cause MSHCs.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and prevalence of musculoskeletal health conditions in survivors of childhood and adolescent cancers: A report from the Swiss childhood cancer survivor study

Christen,

Roser,

Mader

et al. 2024

Cancer Medicine

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PurposeChildhood cancer and its treatment can cause damage to the musculoskeletal system. We aimed to determine the incidence and prevalence of musculoskeletal health conditions (MSHC) in survivors, and to investigate differences by cancer‐related characteristics.MethodsWe used data from the Childhood Cancer Registry and the Swiss Childhood Cancer Survivor Study, including survivors (≥5 years since diagnosis; diagnosed 1976–2015 at <20 years of age) aged ≥15 years at study. Cumulative incidence and prevalence of MSHCs (osteoporosis, limb length discrepancy, limited joint mobility, bone/joint pain, scoliosis, changes to chest/ribs and amputation) were calculated from self‐reported data.ResultsWe included 2645 survivors (53% men; median age 24 years, range 15–59 years). Prevalence and cumulative incidence of any MSHC was 21% and 26%, respectively. Incidence rate for any MSHC was 15.6/1000 person‐years. Scoliosis (8%), bone/joint pain (7%) and limited joint mobility (7%) were the most prevalent MSHC. MSHC co‐occurred with other health conditions in 87% of survivors. We found increased rates of MSHC in women (RR = 1.4, 95%CI: 1.2–1.7), bone tumour survivors (RR = 6.0, 95%CI: 4.5–7.9), survivors older at diagnosis (11–15 years: RR = 1.8, 95%CI: 1.5–2.3), after a relapse (RR = 1.5, 95%CI: 1.3–1.9), treatment with surgery (RR = 1.2, 95%CI: 1.0–1.5), chemotherapy (RR = 1.4, 95%CI: 1.1–1.8) or stem cell transplantation (RR = 1.6, 95%CI: 1.0–2.5), and more recent year of diagnosis (2011–2015: RR = 4.3, 95%CI: 2.8–6.8).ConclusionMSHCs are prevalent in survivors, the risk is increasing in younger survivor cohorts, and MSHCs usually occur in multimorbid survivors. Strengthening of rehabilitation services and appropriate referrals are needed to mitigate the effects of the cancer and cancer treatment.

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Section: 8contrasting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence and prevalence of musculoskeletal health conditions in survivors of childhood and adolescent cancers: A report from the Swiss childhood cancer survivor study

Christen,

Roser,

Mader

et al. 2024

Cancer Medicine

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Antineoplastic therapy is an independent risk factor for dental caries in childhood cancer patients: a retrospective cohort study

Longo,

Rohling,

Silva

et al. 2024

Support Care Cancer

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Assessment of Metabolic Syndrome and Kidney and Heart Function in Childhood Cancer Survivors

et al. 2023

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Background: The survivors of childhood cancer suffer from a number of long-term side effects. These include atherosclerosis and cardiovascular diseases (CVDs) that develop earlier in adulthood than in the rest of the population. The aim of this study was to identify prognostic factors of developing atherosclerosis before the development of symptomatic CVD. Methods: A total of 141 children that were 7–18 years old were examined; there were 116 survivors of childhood malignancies (hematopoietic and lymphoproliferative malignancies—52; neuroblastoma—22; Wilms tumor—24; other solid tumors—18) and 25 healthy controls. Anthropometric measurements, blood pressure measurements, ultrasonography of the abdomen, echocardiography, and laboratory tests were performed. Results: There were no significant differences in gender distribution, time from the end of the treatment, weight, BMI, prevalence of central obesity, blood pressure and resistive index of the renal arteries, lipid profile, or glucose and fibrinogen levels. Patients with solid tumors had a significantly lower height and worse renal function. Patients with hematological malignancies significantly presented the lowest shortening fraction of the left ventricle. The salusin β levels were significantly higher in the control group than among the patients. Conclusions: The type and severity of side effects are closely related to the type of neoplasm and the treatment that has been undergone. Careful observation and regular follow-up are necessary.

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Late effects of childhood cancer treatment in long-term survivors diagnosed before the age of 3 years – A multicenter, nationwide study

Cited by 3 publications

References 38 publications

Incidence and prevalence of musculoskeletal health conditions in survivors of childhood and adolescent cancers: A report from the Swiss childhood cancer survivor study

Incidence and prevalence of musculoskeletal health conditions in survivors of childhood and adolescent cancers: A report from the Swiss childhood cancer survivor study

Antineoplastic therapy is an independent risk factor for dental caries in childhood cancer patients: a retrospective cohort study

Assessment of Metabolic Syndrome and Kidney and Heart Function in Childhood Cancer Survivors

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