Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study

Lopez-Minguez, Jesus; Saxena, Richa; Bandín, Cristina; Scheer, Frank A.J.L.; Garaulet, Marta

doi:10.1016/j.clnu.2017.04.003

Cited by 88 publications

(72 citation statements)

References 38 publications

(55 reference statements)

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“…It is important to highlight that midpoint sleep is highly correlated with DLMO [15]. Recently, Lopez-Minguez et al [14] pointed out that having dinner no later than 2 to 4 h before habitual bedtime would allow recovery of postprandial glycaemia to fasting values prior to the rise of endogenous melatonin levels. It is important to note that, when melatonin is bound to the Mel1b receptor in pancreatic-islet beta cells, it inhibits glucose-stimulated insulin secretion [14].…”

Section: Discussionmentioning

confidence: 99%

“…For example, cross-sectional studies have reported that eating dinner less than two hours before bedtime is significantly associated with hyperglycemia, and higher odds of being overweight or obese [12,13]. In consonance, Garaulet and colleagues [14] showed that late dining resulted in impaired glucose tolerance, mainly due to concurrence between the postprandial period and endogenous melatonin concentrations. However, a limitation of these studies is the use of clock time to characterize the timing of food intake, which fails to accurately characterize meal timing in the context of internal circadian timing [3,11].…”

Section: Introductionmentioning

confidence: 97%

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The Elapsed Time between Dinner and the Midpoint of Sleep Is Associated with Adiposity in Young Women

et al. 2020

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Meal timing relative to sleep/wake schedules is relevant in the search for obesity risk factors. However, clock time does not accurately characterize the timing of food intake in the context of internal circadian timing. Therefore, we studied elapsed between dinner and the midpoint of sleep (TDM) as a practical approach to evaluate meal timing relative to internal timing, and its implications on obesity. To do so, adiposity, sleep, diet, physical activity, and TDM were measured in 133 women. The participants were grouped into four categories according to their sleep timing behavior (early-bed/early-rise; early-bed/late-rise; late-bed/early-rise; late-bed/late-rise). Differences among the categories were tested using ANOVA, while restricted cubic splines were calculated to study the association between TDM and adiposity. Our results show that, although participants had dinner at about the same time, those that had the shortest TDM (early-bed/early-rise group) were found to have significantly higher BMI and waist circumference values (2.3 kg/m2 and 5.2 cm) than the other groups. In addition, a TDM of 6 h was associated with the lowest values of adiposity. The TDM could be a practical approach to personalizing meal timing based on individual sleep/wake schedules. Thus, according to our findings, dining 6 h before the midpoint of sleep is an important finding and could be vital for future nutritional recommendations and for obesity prevention and treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

The Elapsed Time between Dinner and the Midpoint of Sleep Is Associated with Adiposity in Young Women

et al. 2020

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“…1) [32]. For example, it has been shown recently in a randomised, crossover study that late dinner timing, concurrent with elevated night-time melatonin concentrations, impairs glucose tolerance [33]. A causal role for melatonin is suggested by the observation that the significant impairment of glucose tolerance with delayed dinner is only observed in the gain-of-function variant of the MTNR1B gene [33], which has been associated with increased risk for diabetes [34,35].…”

Section: Impact Of Circadian Disruption On Glucose Control In Healthymentioning

confidence: 99%

“…For example, it has been shown recently in a randomised, crossover study that late dinner timing, concurrent with elevated night-time melatonin concentrations, impairs glucose tolerance [33]. A causal role for melatonin is suggested by the observation that the significant impairment of glucose tolerance with delayed dinner is only observed in the gain-of-function variant of the MTNR1B gene [33], which has been associated with increased risk for diabetes [34,35]. This conclusion is further supported by placebo-controlled studies showing that exogenous melatonin administration both in the morning and in the evening impairs glucose tolerance [36] and that this effect is six times larger in MTNR1B risk carriers than in non-carriers [37].…”

Section: Impact Of Circadian Disruption On Glucose Control In Healthymentioning

confidence: 99%

Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes

et al. 2020

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The circadian system generates endogenous rhythms of approximately 24 h, the synchronisation of which are vital for healthy bodily function. The timing of many physiological processes, including glucose metabolism, are coordinated by the circadian system, and circadian disruptions that desynchronise or misalign these rhythms can result in adverse health outcomes. In this review, we cover the role of the circadian system and its disruption in glucose metabolism in healthy individuals and individuals with type 2 diabetes mellitus. We begin by defining circadian rhythms and circadian disruption and then we provide an overview of circadian regulation of glucose metabolism. We next discuss the impact of circadian disruptions on glucose control and type 2 diabetes. Given the concurrent high prevalence of type 2 diabetes and circadian disruption, understanding the mechanisms underlying the impact of circadian disruption on glucose metabolism may aid in improving glycaemic control.

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“…As we expected, carbohydrate composition and timing of food consumption (01:00 h) exacerbated the capillary glucose response in the NP meal compared to the HP meal due to the higher amount of carbohydrate present. Studies conducted in nonshift workers have shown worse glucose tolerance after evening meals 23,24,33 , which in theory would make high carbohydrate consumption deleterious at that time, possibly due to the deleterious effect of extended waking on glucose metabolism 34 and glucose tolerance 35 . Different pathways could contribute to abnormal glucose metabolism linked to sleep restriction, such as reduced brain glucose utilization and insulin resistance 25 .…”

Section: Discussionmentioning

confidence: 99%

Efeito da ingestão de uma refeição hiperproteica durante o turno noturno sobre a resposta metabólica pós-prandial no dia seguinte: um estudo crossover, randomizado e controlado

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A Deus, pela presença constante em minha vida, direcionando minhas escolhas da melhor forma e me dando forças para realizar os meus objetivos. Aos meus pais, Vera e Geraldo, por todo ensinamento, amor, apoio e esforço durante toda minha vida. Vocês são a minha base. Ao meu irmão Sheider, por todo o cuidado que sempre teve como irmão mais velho. Ao meu namorado Mohamad, por cada palavra de conforto, pela paciência, ajuda e incentivo nesta caminhada. A todas as minhas amigas por serem fonte de conforto, especialmente à Paula, por ser minha amiga de todas as horas e que muito me ajudou durante esta jornada. Por todas as conversas de apoio e incentivo. À minha orientadora, profa. Cibele Aparecida Crispim, pela receptividade no grupo, todos os ensinamentos, pela paciência, incentivo e dedicação com seus alunos e com a pesquisa. Aos membros do grupo Ceinutri pelo acolhimento e compartilhamento de conhecimento, especialmente à Catarina, que participou de todo o processo do mestrado de forma ativa, sempre me ajudando, incentivando e compartilhando seus conhecimentos. A todos do Programa de Pós-graduação em Ciências da Saúde, por todo o suporte e oportunidades proporcionadas. Aos participantes, sem os quais não seria possível realizar esse estudo. À FAPEMIG, CNPq e CAPES pelo apoio financeiro. RESUMO Introdução: O trabalho em turnos tem sido associado com doenças nutricionais e metabólicas, sendo que a qualidade, a quantidade e o horário da alimentação são considerados fatores importantes associados ao desenvolvimento de doenças crônicas e ganho de peso em trabalhadores em turnos. No entanto, o impacto da alimentação noturna na resposta metabólica dos trabalhadores em turnos é pouco explorado na literatura. Objetivo: Avaliar o efeito agudo de uma refeição hiperproteica em comparação com uma refeição normoproteica servidas à noite na resposta metabólica pós-prandial de trabalhadores noturnos no dia seguinte. Material e métodos: Foi realizado um ensaio clínico crossover com 14 trabalhadores noturnos do sexo masculino. Os participantes foram acompanhados por 7 dias antes de cada noite de intervenção em relação ao consumo alimentar e padrão de sono. Posteriormente, os participantes foram submetidos a duas condições dietéticas isocalóricas diferentes às 01:00h do turno noturno, com um intervalo de 6 dias entre elas: refeição hiperproteica (HP), composta por 45% de carboidratos, 35% de proteínas e 20% de gorduras; e refeição normoproteica (NP), composta por 65% de carboidratos, 15% de proteínas e 20% de gorduras. Os níveis de glicose capilar pósprandial foram determinados imediatamente antes da ingestão da refeição teste (tempo 0) e 30, 60, 90 e 120 minutos após o término da refeição. No final do turno de trabalho (06:30h) os participantes receberam um café da manhã padrão e os níveis de glicose, insulina e triglicerídeos pós-prandias foram determinados imediatamente antes (tempo 0) e depois a cada 30 minutos por 2h (30, 60, 90, 120 minutos). A avaliação do modelo homeostático para resistência à insulina (HOMA-IR) foi calculada...

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Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study

Abstract: https://clinicaltrials.gov/ct2/show/NCT03003936.

Cited by 88 publications

References 38 publications

The Elapsed Time between Dinner and the Midpoint of Sleep Is Associated with Adiposity in Young Women

The Elapsed Time between Dinner and the Midpoint of Sleep Is Associated with Adiposity in Young Women

Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes

Efeito da ingestão de uma refeição hiperproteica durante o turno noturno sobre a resposta metabólica pós-prandial no dia seguinte: um estudo crossover, randomizado e controlado

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