Lasting amelioration in the clinical course of decompensated alcoholic cirrhosis with boost infusions of mobilized peripheral blood stem cells

Yannaki, Evangelia; Anagnostopoulos, Achilles; Kapetanos, Dimitrios; Xagorari, Angeliki; Iordanidis, Fotis; Batsis, Ioannis; Kaloyannidis, Panayotis; Athanasiou, Evangelia; Dourvas, Georgios; Kitis, G.; Fassas, Αthanasios

doi:10.1016/j.exphem.2006.06.012

Cited by 89 publications

(44 citation statements)

References 22 publications

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“…Our findings therefore highlight a therapeutic means by which these host DRs can be directly stimulated and we propose this pathway as a possible mechanism by which autologous BMC therapy may be beneficial in human liver disease. Animal models of BMC therapy for liver disease and clinical autologous BMC therapy studies are underway with encouraging preliminary results (2,(28)(29)(30). A recent report by our group has shown that a single portal vein injection of macrophages significantly reduces fibrosis in a model of chronic liver injury.…”

Section: Discussionmentioning

confidence: 99%

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

Bird

Boulter

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

145

146

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Tissue progenitor cells are an attractive target for regenerative therapy. In various organs, bone marrow cell (BMC) therapy has shown promising preliminary results, but to date no definite mechanism has been demonstrated to account for the observed benefit in organ regeneration. Tissue injury and regeneration is invariably accompanied by macrophage infiltration, but their influence upon the progenitor cells is incompletely understood, and direct signaling pathways may be obscured by the multiple roles of macrophages during organ injury. We therefore examined a model without injury; a single i.v. injection of unfractionated BMCs in healthy mice. This induced ductular reactions (DRs) in healthy mice. We demonstrate that macrophages within the unfractionated BMCs are responsible for the production of DRs, engrafting in the recipient liver and localizing to the DRs. Engrafted macrophages produce the cytokine TWEAK (TNF-like weak inducer of apoptosis) in situ. We go on to show that recombinant TWEAK activates DRs and that BMC mediated DRs are TWEAK dependent. DRs are accompanied by liver growth, occur in the absence of liver tissue injury and hepatic progenitor cells can be isolated from the livers of mice with DRs. Overall these results reveal a hitherto undescribed mechanism linking macrophage infiltration to DRs in the liver and highlight a rationale for macrophage derived cell therapy in regenerative medicine.liver regeneration | adult stem cell

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Section: Discussionmentioning

confidence: 99%

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

Bird

Boulter

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

145

146

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show abstract

“…The increased mobilization of bone marrow-derived stem cells to the liver has been shown to exert beneficial effects in rodent cirrhosis model systems [42][43][44]. The paradigm of stem cell-based therapy has now shifted towards the enrichment of specific bone marrow-derived stem cells, particularly CD34+, CD45+ and CD133+ HSCs obtained from the peripheral blood [20,45]. The enrichment of peripheral BM-HSCs can be achieved by either purification of aspirated BM or the mobilization of HSCs using Granulocyte Colony Stimulating Factor (G-CSF).…”

Section: Bone Marrow-derived Hematopoietic Stem Cells (Bm-hscs) In Aumentioning

confidence: 99%

Adult Stem Cell Therapy in Liver Cirrhosis Management: Current Practices and Future Perspectives

Subbanna¹,

Radha²,

Choy³

et al. 2017

Int J Stem Cell Res Ther

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“…In addition, Yannaki E et. al (20). reported two cases treated with booster infusions of autologous mobilized hematopoietic stem cells to regenerate a cirrhotic liver (Case No 4 Table).…”

Section: Clinical Application and Perspectivesmentioning

confidence: 99%

“…In cardiology, large-scale controlled and double-blinded clinical trials were performed in a number of centers (18). Some studies have demonstrated clinical benefits, whereas in others the differences have been less significant (Table 1) (9,(19)(20)(21)(22)(23)(24)(25). Especially G-CSF-based BM cell mobilization, induced improvement of liver function in chronic liver failure in one case (Case No 3 Table) (21); this procedure was safe and effective and can be exploited as a simple therapeutic strategy in patients with end stage liver disease.…”

Section: Clinical Application and Perspectivesmentioning

confidence: 99%

Liver Stem Cells Derived from the Bone Marrow and Umbilical Cord Blood

Ryu¹

2009

Int J Stem Cells

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Lasting amelioration in the clinical course of decompensated alcoholic cirrhosis with boost infusions of mobilized peripheral blood stem cells

Cited by 89 publications

References 22 publications

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

Adult Stem Cell Therapy in Liver Cirrhosis Management: Current Practices and Future Perspectives

Liver Stem Cells Derived from the Bone Marrow and Umbilical Cord Blood

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