LASIK-induced corneal changes after correction of hyperopia with and without application of Mitomycin-C

Moawad, Ehab M.; Elghany, Ahmed A. Abd; Gab-Alla, Amr A; Elbassiouny, Osama M.; Badawy, Mohsen S.

doi:10.1186/s12886-019-1100-7

Cited by 6 publications

(7 citation statements)

References 6 publications

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“…Topographic stability over one-year follow-up was documented in our study similar to Moawad et al [ 41 ] who reported fewer topographic changes after mitomycin C assisted hyperopic LASIK. Gauthier-Fournet et al [ 42 ] evaluated the effect of postoperative keratometry on the safety of LASIK for high hyperopia up to 9.5 D and found that corneas with steeper postoperative keratometries were associated with higher loss of CDVA.…”

Section: Discussionsupporting

confidence: 89%

Twelve-month outcomes of single-step transepithelial photorefractive keratectomy for moderate hyperopia and hyperopic astigmatism

et al. 2023

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Background Conventional mechanical or alcohol-assisted photorefractive keratectomy (PRK) techniques for correction of hyperopia and hyperopic astigmatism were associated with inconsistent results. The aim of this study is to evaluate the 12-month visual and refractive outcomes of the relatively new single-step transepithelial photorefractive keratectomy (TE-PRK) for moderate hyperopia and hyperopic astigmatism. Methods This is a prospective interventional study. Forty-eight eyes of 30 patients with moderate hyperopia or hyperopic astigmatism with a cycloplegic spherical equivalent refraction (SEQ) between 2.0 and 4.5 diopters (D) underwent single-step StreamLight® TE-PRK using EX500 excimer laser (Alcon Laboratories, USA). The main outcome measures were recorded at 6 and 12 months postoperatively including assessment of logarithm of the minimum angle resolution (logMAR) uncorrected and corrected distance visual acuity (UDVA, CDVA), cycloplegic refraction, corneal topographic changes as well as post-PRK peripheral haze grading. Results The mean preoperative cycloplegic SEQ was significantly reduced from 3.21 ± 0.61 D to 0.35 ± 0.04 D and 0.41 ± 0.04 D at 6 and 12 months, respectively (P < 0.001). The mean preoperative UDVA significantly improved from 0.53 ± 0.02 logMAR to 0.07 ± 0.01 logMAR and 0.08 ± 0.01 logMAR at 6 and 12 months, respectively (P < 0.001) while the mean preoperative logMAR CDVA showed non-significant change over time throughout the study (P = 0.135). At the end of the study, 41 eyes (85.4%) achieved UDVA of 20/25 or better and no eye lost any lines of CDVA. Thirty-eight eyes (79.1%) had a postoperative cycloplegic cylinder of 0.5 D or less at 12 months. The mean preoperative mean keratometry showed significant increase at 6 and 12 months postoperatively (P < 0.001) while there was no significant change between the two postoperative visits denoting topographic stability (P = 0.058). The mean postoperative Q value at 6 and 12 months showed a significant prolate shift (P < 0.001). No haze was observed in 62.5% and 85.4% of the enrolled eyes at 6 and 12 months, respectively. Conclusions Single-step StreamLight® TE-PRK for moderate hyperopia and hyperopic astigmatism achieved acceptable visual and refractive outcomes. Trial registration: (Clinicaltrials.gov): NCT05261685, 2 March 2022, retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT05261685

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Section: Discussionsupporting

confidence: 89%

Twelve-month outcomes of single-step transepithelial photorefractive keratectomy for moderate hyperopia and hyperopic astigmatism

et al. 2023

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“…Previous studies for LASIK or conventional PRK in hyperopia removal had used smaller optical zones, which might have resulted in unpredictable post-operative vision and higher regression. 33 , 35 , 39 , 40 The sudden transition area from ablated to unablated surface, leading to uncontrolled tissue regeneration, is thought to cause such unpredictability.…”

Section: Discussionmentioning

confidence: 99%

Transepithelial Photorefractive Keratectomy for Hyperopia Correction: An Uncharted Territory

Sabhapandit,

Abdussamad,

Shaik

et al. 2023

OPTH

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Transepithelial photorefractive keratectomy (Trans PRK) is a relatively new technology for refractive surgery and has shown promising results in myopia correction. The data on hyperopia correction by this method are limited. In this review, we have attempted to understand the outcomes of this technology on hyperopic eyes. There are comparable results with conventional PRK and laser in situ keratomileusis (LASIK) as far as refractive stability, regression rate, predictability, and post-operative complications are concerned. The best results have been obtained in lower hyperopic corrections. In moderate to higher hyperopia, the limited data available show higher regression, unstable visual outcomes, and increased stromal haze. There is a need to evaluate the technology further to understand its success for hyperopic refractive surgery.

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“…Increasing the ablation zone 6 and application of 0.02% mitomycin C may help reduce the risk of regression and scarring. 13 …”

Section: Discussionmentioning

confidence: 99%

Early Outcomes of Two Treatment Modes of PresbyLASIK: Monocular vs. Micro-Monovision

Agarwal¹,

Thornell²

2022

OPTH

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Purpose To report the visual, refractive and subjective outcomes of presbyLASIK for the correction of presbyopia. Methods Monocular (20 eyes) or micro-monovision (12 eyes) presbyLASIK was performed on a total of 32 eyes in 16 patients (50% female, average age 55±4.6 years) using the Zeiss VisuMax 400Hz femtosecond and Schwind Amaris 1050RS excimer laser platform. Predictability, safety and efficacy were assessed and compared at 4–6 weeks, 3 months and 6 months. Results were considered significant if P < 0.05. Results For monocular treatments, average postoperative spherical equivalent (SE) was 0.1±0.1 D and −0.86±0.5 D at 4–6 weeks postoperatively for distance and near eyes respectively; 90% eyes achieved SE ±1.0 D of the target. Postoperative binocular uncorrected distance (UDVA), intermediate (UIVA) and near visual acuity (UNVA) were −0.03±0.1 LogMAR (20/20), 0.09±0.26 LogMAR (N4) and 0.29±0.11 LogMAR (N6) respectively with 90% patients achieving binocular UDVA of 20/20 or better. For micro-monovision treatments, average postoperative SE was −0.33±0.51 D and −1.60±0.78 D at 4–6 weeks postoperatively for distance and near eyes respectively; 100% eyes achieved SE ±1.0 D of the target. Postoperative binocular UDVA, UIVA and UNVA were 0.05±0.16 LogMAR (20/20), −0.02±0.10 LogMAR (N3) and 0.23±0.08 LogMAR (N5) respectively with 67% patients achieving binocular UDVA of 20/20 or better. Conclusion Monocular and micro-monovision presbyLASIK are both effective options for the treatment of presbyopia. Monocular treatments are more likely to be well tolerated by patients who prefer to preserve exceptional distance vision, while micro-monovision treatments may be better suited to patients who can tolerate compromises in distance vision in order to attain greater intermediate vision function.

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LASIK-induced corneal changes after correction of hyperopia with and without application of Mitomycin-C

Cited by 6 publications

References 6 publications

Twelve-month outcomes of single-step transepithelial photorefractive keratectomy for moderate hyperopia and hyperopic astigmatism

Twelve-month outcomes of single-step transepithelial photorefractive keratectomy for moderate hyperopia and hyperopic astigmatism

Transepithelial Photorefractive Keratectomy for Hyperopia Correction: An Uncharted Territory

Early Outcomes of Two Treatment Modes of PresbyLASIK: Monocular vs. Micro-Monovision

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