Lasianthera Africana leaves inhibits α-amylase α-glucosidase, angiotensin-I converting enzyme activities and Fe2+-induced oxidative damage in pancreas and kidney homogenates

Shodehinde, Sidiqat A.; Oyeleye, Sunday I.; Olasehinde, Tosin A.; Adebayo, Adeniyi A.; Oboh, Ganiyu; Boligon, Alexandra Augusti

doi:10.1007/s13596-017-0256-z

Cited by 26 publications

(19 citation statements)

References 43 publications

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“…Plant foods are rich source of biologically important chemical compounds, and their intake has been reported to possess protective potential against degenerative diseases (Cai, Luo, Sun, & Corke, ). Polyphenols, a prominent class of phytochemical, are well known for their biological activities (Chu, Sun, Wu, & Liu, ; Shodehinde et al, ). This study revealed that UEF extract had higher total phenol and flavonoid contents than IEF extract.…”

Section: Resultsmentioning

confidence: 99%

“…300 µl of 8.1% SDS, 600 µl of acetic acid/HCl (pH 3.4) and 600 µl 0.8% thiobarbituric acid were added and boiled for 1 hr. Lipid peroxidation was measured by quantifying amount of thiobarbituric acid reactive species produced at 532 nm (Shodehinde et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…Lipid peroxidation was measured by quantifying amount of thiobarbituric acid reactive species produced at 532 nm (Shodehinde et al, 2017).…”

Section: Preparation Of Tissue Homogenate and Lipid Peroxidation Assaymentioning

confidence: 99%

“…Studies revealed that food rich in antioxidants have protective role against metabolic disorders, including diabetes and hypertension (Oyeleye, Adebayo, Ogunsuyi, Dada, & Oboh, 2018;Shodehinde et al, 2017). Imbalance between antioxidant and free radicals had been reported to play crucial role in aging and pathogenesis of many disorders, including diabetes mellitus particularly type-2 diabetes (Pham-Huy, He, & Pham-Huy, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Phenolic distribution, antioxidant activity, and enzyme inhibitory properties of eggplant ( Solanum aethiopicum ) cultivated in two different locations within Nigeria

et al. 2019

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Solanum aethiopicum is commonly cultivated in Nigeria for its nutritional and medicinal properties. Although, information on the possible effect of location on the biological activities of S. aethiopicum has not been reported, however, present research work investigated the phenolic contents and distribution, antioxidative properties, and enzyme inhibitory activities of S. aethiopicum collected from two locations in Nigeria. HPLC phenolic profile, polyphenol contents, free radical scavenging activities, and inhibitory effect of eggplant extracts on carbohydrate metabolizing enzymes were carried out. Significant variations were observed in the phenolic profile, polyphenol contents, antioxidant activities, and enzymes inhibitory properties of the extracts from different locations. In most of the analyses carried out, extract of eggplant fruit collected from Uyo (UEF) showed higher activities than the one obtained from Ibadan (IEF). Thus, findings from this study revealed that geographical location may influence the phenolic contents, antioxidant, and enzymes inhibitory properties of eggplant fruits. Practical applications The geographical location of a particular place determines the nature and biological activities of plants cultivated in the area. Hence, we presented the effect of location on the phenolic profile, antioxidant, and enzyme inhibitory properties of eggplant fruit (S. aethiopicum) cultivated in two different locations in Nigeria. However, data generated in this study showed the effect of location on phenolic composition and biological activities of eggplant fruit cultivated in Nigeria.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Lipid peroxidation was measured by quantifying amount of thiobarbituric acid reactive species produced at 532 nm (Shodehinde et al, 2017).…”

Section: Preparation Of Tissue Homogenate and Lipid Peroxidation Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phenolic distribution, antioxidant activity, and enzyme inhibitory properties of eggplant ( Solanum aethiopicum ) cultivated in two different locations within Nigeria

et al. 2019

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“…The following biochemical assays were carried out on the penile tissue homogenate: protein determination (Bradford, ); nitric oxide (NO) level (Miranda, Espay, & Wink, ); arginase activity (Zhang, Hein, Wang, Chang, & Kuo, ); phosphodiesterase‐5 (PDE‐5) activity (Ademosun, Adebayo, & Oboh, ; Oboh, Adebayo, Ademosun, & Boligon, ); adenosine deaminase activity (Guisti & Galanti, ); acetylcholinesterase (AChE) activity (Ellman, Courtney, Andres, & Feather‐Stone, ; Rocha, Emanuelli, & Pereira, ); total thiol and nonprotein thiol level (Ellman, ); thiobarbituric acid reactive substances (TBARS; Shodehinde et al, ); catalase activity (Sinha, ) and superoxide dismutase activity (Alia, Horcajo, Bravo, & Goya, ).…”

Section: Methodsmentioning

confidence: 99%

Orange peels modulate antioxidant markers and key enzymes relevant to erection in the penile tissue of paroxetine‐treated rats

2019

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In comparison to other antidepressant drugs, erectile dysfunction (ED) is more pronounced in paroxetine use. On the other hand, orange (Citrus sinensis) peels commonly consumed in various forms are used in folkloric medicine for ED management. Thus, this study evaluated the effect of orange peels infusion on sexual behaviour, nitric oxide (NO) level and some enzymes (arginase, phosphodiesterase-5 [PDE-5], acetylcholinesterase [AChE] and adenosine deaminase [ADA]) in paroxetine-treated rats. Erectile dysfunction was induced with paroxetine (10 mg/kg body weight). The animals were grouped into five (n = 6): normal rats; paroxetine-induced rats; paroxetine-induced rats treated with sildenafil citrate (5 mg/kg); paroxetine-induced rats treated with orange peels infusion (50 mg/kg); Paroxetine induced rats treated with orange peel infusions (100 mg/kg). The results revealed a significant decrease in sexual behaviour, NO level and the activities of antioxidant enzymes, while there was a significant increase in arginase, PDE-5, AChE and ADA activities in paroxetine-induced rats. However, orange peel infusions ameliorated erectile dysfunction in paroxetine-treated rats. This study showed some possible biochemical basis underlying the use of orange peels infusion in erectile dysfunction management. K E Y W O R D S erectile dysfunction, orange peels, paroxetine, sexual behaviour, sildenafil

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Synthesis and biological evaluation of phloroglucinol derivatives possessing α‐glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity

Burmaoğlu

Yılmaz

Taslimi

et al. 2018

Archiv der Pharmazie

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A series of novel phloroglucinol derivatives were designed, synthesized, characterized spectroscopically and tested for their inhibitory activity against selected metabolic enzymes, including α-glycosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase I and II (hCA I and II). These compounds displayed nanomolar inhibition levels and showed K values of 1.14-3.92 nM against AChE, 0.24-1.64 nM against BChE, 6.73-51.10 nM against α-glycosidase, 1.80-5.10 nM against hCA I, and 1.14-5.45 nM against hCA II.

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Lasianthera Africana leaves inhibits α-amylase α-glucosidase, angiotensin-I converting enzyme activities and Fe2+-induced oxidative damage in pancreas and kidney homogenates

Cited by 26 publications

References 43 publications

Phenolic distribution, antioxidant activity, and enzyme inhibitory properties of eggplant ( Solanum aethiopicum ) cultivated in two different locations within Nigeria

Phenolic distribution, antioxidant activity, and enzyme inhibitory properties of eggplant ( Solanum aethiopicum ) cultivated in two different locations within Nigeria

Orange peels modulate antioxidant markers and key enzymes relevant to erection in the penile tissue of paroxetine‐treated rats

Synthesis and biological evaluation of phloroglucinol derivatives possessing α‐glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity

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