Laser treatment of epidermal nevi: A multicenter retrospective study with long-term follow-up

Alkhalifah, Azzam; Fransen, Frederike; Duff, F. Le; Lacour, Jean‐Philippe; Wolkerstorfer, Albert; Passeron, Thierry

doi:10.1016/j.jaad.2019.06.013

Cited by 17 publications

(13 citation statements)

References 47 publications

(13 reference statements)

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“…However, only two patients showed moderate lightening in pigmentation, while six patients showed no change to slight lightening 36 . Similarly in a retrospective study with long‐term follow‐up, Q‐switched Nd: YAG lasers (1064 nm and 532 nm) showed no improvement in almost all patients with Becker nevus 37 . Q‐switched Nd: YAG lasers were ineffective in reducing hyperpigmentation of BN, no matter of their wavelengths.…”

Section: Treatment For Bnmentioning

confidence: 91%

“…Alexandrite (Cr 3+ :BeAl 2 O 4 ) is used as the laser medium in the alexandrite laser producing 755 nm light 26 . Only three patients saw any improvement when Alkhalifah et al used QS 755 nm laser to treat several patients 37 . After four sessions with the QS 755‐nm laser, only one showed a good to excellent improvement with no recurrence 37 .…”

Section: Treatment For Bnmentioning

confidence: 99%

“…Only three patients saw any improvement when Alkhalifah et al used QS 755 nm laser to treat several patients 37 . After four sessions with the QS 755‐nm laser, only one showed a good to excellent improvement with no recurrence 37 . In Zhong's large cohort study, 1–5 sessions of 755‐nm QS alexandrite laser at fluence of 3.6–8.5 J/cm 2 and pulse 50 ns were used to treat 41 BN patients, who all completed follow‐up 43 .…”

Section: Treatment For Bnmentioning

confidence: 99%

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An update on Becker's nevus: Pathogenesis and treatment

Zhou

Zheng

Hamblin

et al. 2022

Dermatologic Therapy

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Becker's nevus (BN) manifests as a hyperpigmented, sometimes hypertrichotic plaque/patch over the chest and shoulder, and it is in the category of benign cutaneous hamartomas. BN has elongation and fusion of the rete ridge, keratotic plugging, sebaceous hyperplasia, smooth muscle hyperplasia, and hyperpigmentation of the basal/suprabasal layer histologically. This article highlights all issues involved in pathogenesis and treatment options of BN. According to current research, postzygotic ACTB mutations induce BN and Becker's nevus syndrome (BNS). Although several therapy strategies were utilized to treat the pigmentary and hypertrichotic aspects of BN, no definitive standard treatment was identified to far, and further research is needed to better educate BN care.

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Section: Treatment For Bnmentioning

confidence: 91%

Section: Treatment For Bnmentioning

confidence: 99%

Section: Treatment For Bnmentioning

confidence: 99%

See 1 more Smart Citation

An update on Becker's nevus: Pathogenesis and treatment

Zhou

Zheng

Hamblin

et al. 2022

Dermatologic Therapy

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“…All photographs were retrospectively evaluated by two dermatologists independently for Physician Global Assessment (PGA). The scoring criteria in this study were based on a study conducted by Alkhalifah et al 12 The PGA range in this study was 0-6, and it can be further classified as follows: 0 = 100% improvement, 1 = 90-99% improvement, 2 = 50-89% improvement,…”

Section: Assessmentmentioning

confidence: 99%

“…We reviewed other VEN treatment studies and summarized the efficacy, recurrence rate, patient satisfaction, and adverse reactions of different therapies, as shown in Table3 4,12,13,[23][24][25][26]. Retrospective research by Lapidoth et al13 evaluated 62 patients with VEN receiving cryotherapy for 2-12 sessions.…”

mentioning

confidence: 99%

Safety and effectiveness of 5‐aminolevulinic acid photodynamic therapy combined with fractional micro‐plasma radio‐frequency treatment for verrucous epidermal nevus: A retrospective study with long‐term follow‐up

Dai

Huang

et al. 2021

The Journal of Dermatology

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Epidermal nevi (EN) are proliferative epithelial diseases initially described by Von Baerensprung in 1863. The incidence rate is 1-3‰, and there is no preference for sex or race. 1 Although the etiology and pathogenesis are not completely clear, it has been reported that mutations in KRAS, PIK3CA, and FGFR3 genes are related to EN. 2,3 Verrucous epidermal nevus (VEN), also known as keratinocytic epidermal nevus (KEN), is one type of EN. The typical manifestation of VEN is yellow to tan verrucous papules or plaques with different sizes, shapes, and distributions. VEN usually occurs in infancy or early childhood, aggravating with increasing age. Lesions distribute on any part of the body, including the face, limbs, and trunk.Depending on the distribution, VEN is classified as localized VEN, systematized VEN, nevus unius lateralis, inflammatory linear verrucous epidermal nevus, and ichthyosis hystrix. 4

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Combination 1550 nm non‐ablative fractional resurfacing and laser hair removal for treatment of Becker's nevi in skin types III–VI

et al. 2022

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Objectives Becker's nevus is a cosmetically bothersome benign hamartoma typically associated with basal layer hyperpigmentation and hypertrichosis. We herein present the largest case series characterizing treatment parameters and clinical outcomes of combined 1550 nm non‐ablative fractional resurfacing and laser hair removal (long‐pulsed neodymium‐doped yttrium aluminum garnet or alexandrite) in the treatment of Becker's nevus. This is also the largest case series of laser treatment of Becker's nevus in Fitzpatrick skin types V and VI. Methods We performed a retrospective review of patients treated between 2016 and 2021. Clinical photographs were graded by three independent physicians using a 5‐point visual analog scale. Results Twelve patients (mean age: 24.8 years, Fitzpatrick skin types III–VI) were treated for Becker's nevus on the face (4) or the trunk and/or extremities (8). Four patients were Fitzpatrick skin types V or VI. On average, patients received 5.3 treatments in 1–4‐month intervals. Ten of the 12 patients had concomitant laser hair removal preceding same‐day non‐ablative fractional resurfacing (n = 7 with long‐pulsed 1064 nm neodymium‐doped yttrium aluminum garnet and n = 3 with long‐pulsed 755 nm alexandrite). The number of treatments with each modality was determined by patient satisfaction with improvement in hyperpigmentation and hypertrichosis. At follow‐up, which ranged from 6 to 40 weeks (mean 10.5 weeks), patients were given a mean improvement score of 51%–75%. No long‐term adverse events were encountered in either group. Limitations include a small sample size and a lack of long‐term follow‐up. Conclusion Combination 1550 nm non‐ablative fractional resurfacing and laser hair removal is safe and efficacious in the cosmetic reduction of hyperpigmentation and hypertrichosis associated with Becker's nevus, including those with Fitzpatrick skin types V and VI.

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Laser treatment of epidermal nevi: A multicenter retrospective study with long-term follow-up

Cited by 17 publications

References 47 publications

An update on Becker's nevus: Pathogenesis and treatment

An update on Becker's nevus: Pathogenesis and treatment

Safety and effectiveness of 5‐aminolevulinic acid photodynamic therapy combined with fractional micro‐plasma radio‐frequency treatment for verrucous epidermal nevus: A retrospective study with long‐term follow‐up

Combination 1550 nm non‐ablative fractional resurfacing and laser hair removal for treatment of Becker's nevi in skin types III–VI

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