Laser surface modification of poly(ε-caprolactone) (PCL) membrane for tissue engineering applications

Tiaw, K.S.; Goh, S. W.; Hong, MH; Wang, Zengbo; Lan, Bin; Teoh, S.H.

doi:10.1016/j.biomaterials.2004.03.010

Cited by 144 publications

(103 citation statements)

References 13 publications

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“…In the case of femtosecond laser, the results gathered from the wettability test revealed that the PCL membranes with holes perforated at lower pulse numbers had higher SEs. At lower pulse numbers, the degree of surface roughness was higher because there were more surface asperities due to a greater ''splattering'' effect [35]. If compared, the results from the KrF treatment suggested that increasing the pulse number (corresponding to a longer laser irradiation time) at both energies increased the surface hydrophilicity of the PCL.…”

Section: Introductionmentioning

confidence: 93%

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Wettability and Other Surface Properties of Modified Polymers

Kasálková¹,

Slepička²,

Kolská³

et al. 2015

Wetting and Wettability

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Surface wettability is one of the crucial characteristics for determining of a material's use in specific application. Determination of wettability is based on the measurement of the material surface contact angle. Contact angle is the main parameter that characterizes the drop shape on the solid surface and is also one of the directly measurable properties of the phase interface. In this chapter, the wettability and its related properties of pristine and modified polymer foils will be described. The wettability depends on surface roughness and chemical composition. Changes of these parameters can adjust the values of contact angle and, therefore, wettability. In the case of pristine polymer materials, their wettability is unsuitable for a wide range of applications (such as tissue engineering, printing, and coating). Polymer surfaces can easily be modified by, e.g., plasma discharge, whereas the bulk properties remain unchanged. This modification leads to oxidation of the treated layer and creation of new chemical groups that mainly contain oxygen. Immediately after plasma treatment, the values of the contact angles of the modified polymer significantly decrease.In the case of a specific polymer, the strongly hydrophilic surface is created and leads to total spreading of the water drop. Wettability is strongly dependent on time from modification.Wettability plays a key role, e.g., in the development of biomaterials in tissue engineering and regenerative medicine. Biocompatibility tests of the cell adhesion, proliferation and viability are performed in an aqueous medium, and it is necessary to control the surface wettability. Various cell types have different requirements on surface properties, but while maintaining suitable parameters, the optimal value of © 2015 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.water contact angle for cell adhesion is in the interval of 50-70°. In the case of polymers, which have usually higher values of contact angles, the decrease in water contact angle and adjustment of the surface may be accomplished by introducing selected chemical groups (by plasma treatment), chemical compounds (by grafting, i.e., chemical bath deposition), or nanoparticles. In the case of grafting of polyethylene glycol (PEG) on the plasma activated high-density polyethylene was under "properly" selected conditions of modification (molecular weight of PEG, concentration of PEG in solution) prepared layers that positively influenced the cell adhesion. In addition, low concentration of gold nanoparticles increased the number of adhered cells without decreasing cell viability.Whether the surface of the polymeric substrate is attractive for the adhesion and proliferation of cells is determined not only by wettability but also by a range of other surface properties...

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Section: Introductionmentioning

confidence: 93%

“…Excimer laser and femtosecond laser were also used for the surface modification of PCL membranes for tissue engineering applications [35]. In the case of femtosecond laser, the results gathered from the wettability test revealed that the PCL membranes with holes perforated at lower pulse numbers had higher SEs.…”

Section: Introductionmentioning

confidence: 99%

Wettability and Other Surface Properties of Modified Polymers

Kasálková¹,

Slepička²,

Kolská³

et al. 2015

Wetting and Wettability

View full text Add to dashboard Cite

show abstract

“…34 The contact angle measured on the surface of the scaffolds added with m_MS and WP was significantly lower than that on the scaffold made only with PCL regardless of the added amounts of WP. In the groups containing m_MS and WP added, the contact angle tended to decrease as the addition amount of WP increased.…”

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confidence: 99%

Enhanced biocompatibility and osteogenic potential of mesoporous magnesium silicate/polycaprolactone/wheat protein composite scaffolds

Kang

Wei

Shin

et al. 2018

IJN

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Background Successful bone tissue engineering using scaffolds is primarily dependent on the properties of the scaffold, including biocompatibility, highly interconnected porosity, and mechanical integrity. Methods In this study, we propose new composite scaffolds consisting of mesoporous magnesium silicate (m_MS), polycaprolactone (PCL), and wheat protein (WP) manufactured by a rapid prototyping technique to provide a micro/macro porous structure. Experimental groups were set based on the component ratio: (1) WP0% (m_MS:PCL:WP =30:70:0 weight per weight; w/w); (2) WP15% (m_MS:PCL:WP =30:55:15 w/w); (3) WP30% (m_MS:PCL:WP =30:40:30 w/w). Results Evaluation of the properties of fabricated scaffolds indicated that increasing the amount of WP improved the surface hydrophilicity and biodegradability of m_MS/PCL/WP composites, while reducing the mechanical strength. Moreover, experiments were performed to confirm the biocompatibility and osteogenic differentiation of human mesenchymal stem cells (MSCs) according to the component ratio of the scaffold. The results confirmed that the content of WP affects proliferation and osteogenic differentiation of MSCs. Based on the last day of the experiment, ie, the 14th day, the proliferation based on the amount of DNA was the best in the WP30% group, but all of the markers measured by PCR were the most expressed in the WP15% group. Conclusion These results suggest that the m_MS/PCL/WP composite is a promising candidate for use as a scaffold in cell-based bone regeneration.

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“…Different frequencies caused channel creation and cavities on the scaffold and thus by surface modification, hydrophilic property was somewhat increased. 43,44 Another factor that affects cell infiltration is vascular scaffolds' wall thickness. For this purpose, a team of researchers after electrospinning the PCL microfibers, began spinning PCL nanofiber on previous scaffolds and by increasing the electrospinning time, found different thicknesses.…”

Section: Scaffold Surfacementioning

confidence: 99%