Evaluation of Mechanical Properties and Medical Applications of Polycaprolactone Small Diameter Artificial Blood Vessels

Mirbagheri, Mahnazsadat; Mohebbi-Kalhori, Davod; Jirofti, Nafiseh

doi:10.15171/ijbsm.2017.12

Cited by 29 publications

(18 citation statements)

References 54 publications

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“…ES is a very promising method based on the generation of polymer fibers from a blend of polymers and drugs in a strong electric field. The advantages of the ES method are the ability to obtain fibers with different diameters (from nm to µm) and ultrastructures, broad material suitability, and high cost effectiveness [30,31]. Several parameters have an influence on the structure and morphology of polymer fibers, including voltage, collector to needle distance, solution flow rate, polymer concentration, solvent type, dielectric constant, temperature, pressure, and moisture [31].…”

Section: Preparation and Characterization Of The Srl Matricesmentioning

confidence: 99%

“…ES is based on the generation of polymer fibers from a blend of polymers and drugs in a strong electric field. The advantages of the ES method are the ability to obtain fibers of different diameters and ultrastructures laid in a 3D matrix, as well as its suitability for a broad range of materials, cost effectiveness, and mechanical support from the stented area that covers the inter-strut area (e.g., the InspireMD CGuard stents consisting of a fine mesh that inhibits neointima growth thanks to the prevention of cell migration from the damaged area) [29][30][31]. Drug release and dissolution of the bioactive substance can be controlled through the structure of polymer fibers, which is determined by the composition of the ES.…”

Section: Introductionmentioning

confidence: 99%

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Sirolimus-Eluting Electrospun-Produced Matrices as Coatings for Vascular Stents: Dependence of Drug Release on Matrix Structure and Composition of the External Environment

et al. 2020

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Although a number of drug-eluting coatings for vascular stents (VSs) have been developed and are in commercial use, more efficient stent coatings and drug delivery systems are needed. Sirolimus (SRL) is a clinically important drug with antiproliferative and immunosuppressive activities that is widely used for coating stents. Here, we characterized SRL-enriched matrices, intended for coating vascular stents, that were produced by electrospinning (ES) on a drum collector from a solution of polycaprolactone (PCL) and human serum albumin (HSA), 1,1,1,3,3,3-hexafluoroisopropanol (HFIP), dimethyl sulfoxide (DMSO), and SRL. The release of tritium-labeled SRL (3H-SRL) from matrices in phosphate-buffered saline (PBS) or human blood plasma (BP) was studied. The introduction of DMSO in the ES blend decreased SRL release. The use of BP significantly accelerated SRL release through binding with serum biomolecules. The exchange of PBS or BP after every time point also increased SRL release. The maximum SRL release in BP was observed at 3 days. The matrices produced from the ES solution with DMSO and HSA released no more than 80% SRL after 27 days in BP, even under medium exchange conditions. Therefore, PCL-based matrices containing HSA, SRL, and DMSO can be used for coating VSs with prolonged SRL delivery.

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Section: Preparation and Characterization Of The Srl Matricesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sirolimus-Eluting Electrospun-Produced Matrices as Coatings for Vascular Stents: Dependence of Drug Release on Matrix Structure and Composition of the External Environment

et al. 2020

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“…However, there is a limitation of fiber dimensions and arrangements in this technique. [39][40][41][42]…”

Section: Template Synthesismentioning

confidence: 99%

Electrospun biomimetic polymer nanofibers as vascular grafts

Malik

Sundarrajan

Hussain

et al. 2020

Mat Design & Process Comms

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Despite all other technologies reported in literature, electrospinning has gained significant importance because of its ability to fabricate nanostructures with distinctive properties, including high surface area and porosity. Electrospinning has been evolved as the most widely used technique in the recent century. It has been employed in various biomedical applications such as tissue-engineered vascular grafts. This can develop fibrous scaffolds that mimic the structure of extracellular matrix of native blood vessels, suitable for the promotion of cell adhesion, proliferation, and cell growth. There is a growing demand for tissue-engineered vascular grafts for the replacement of damaged or defected blood vessels in cardiovascular diseases. The purpose of this review is to summarize recent developments related to electrospun vascular grafts with different synthetic and natural polymers and electrospinning parameters that affect the final properties of vascular grafts. The main focus of this review is also to describe the previously used materials for electrospun vascular grafts and their applications with respect to small and large diameter vascular grafts.

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“…Synthetic materials produced from polycaprolactone (PCL) are widely used in medicine owing to the PCL biocompatibility, good mechanical properties, and ease of manufacturing [ 20 ]. The materials produced from pure PCL possess hydrophobicity, a low degradation rate, and a low cell compatibility.…”

Section: Introductionmentioning

confidence: 99%

Influence of Elongation of Paclitaxel-Eluting Electrospun-Produced Stent Coating on Paclitaxel Release and Transport through the Arterial Wall after Stenting

et al. 2021

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It was previously shown that polycaprolactone (PCL)-based electrospun-produced paclitaxel (PTX)-enriched matrices exhibit long-term drug release kinetics and can be used as coatings for drug-eluting stents (DES). The installation of vascular stents involves a twofold increase in stent diameter and, therefore, an elongation of the matrices covering the stents, as well as the arterial wall in a stented area. We studied the influence of matrix elongation on its structure and PTX release using three different electrospun-produced matrices. The data obtained demonstrate that matrix elongation during stent installation does not lead to fiber breaks and does not interfere with the kinetics of PTX release. To study PTX diffusion through the expanded artery wall, stents coated with 5%PCL/10%HSA/3%DMSO/PTX and containing tritium-labeled PTX were installed into the freshly obtained iliac artery of a rabbit. The PTX passing through the artery wall was quantified using a scintillator β-counter. The artery retained the PTX and decreased its release from the coating. The retention of PTX by the arterial wall was more efficient when incubated in blood plasma in comparison with PBS. The retention/accumulation of PTX by the arterial wall provides a prolonged drug release and allows for the reduction in the dose of the drugs in electrospun-produced stent coatings.

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Evaluation of Mechanical Properties and Medical Applications of Polycaprolactone Small Diameter Artificial Blood Vessels

Cited by 29 publications

References 54 publications

Sirolimus-Eluting Electrospun-Produced Matrices as Coatings for Vascular Stents: Dependence of Drug Release on Matrix Structure and Composition of the External Environment

Sirolimus-Eluting Electrospun-Produced Matrices as Coatings for Vascular Stents: Dependence of Drug Release on Matrix Structure and Composition of the External Environment

Electrospun biomimetic polymer nanofibers as vascular grafts

Influence of Elongation of Paclitaxel-Eluting Electrospun-Produced Stent Coating on Paclitaxel Release and Transport through the Arterial Wall after Stenting

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