Laser scanning tomography and stereophotogrammetry in three-dimensional optic disc analysis

Burk, Reinhard; Rohrschneider, Klaus; Takamoto, Takenori; Völcker, H. E.; Schwartz, Bernard

doi:10.1007/bf00918840

Cited by 46 publications

(31 citation statements)

References 17 publications

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“…The method used by this device has been described in detail. [38][39][40][41][42][43][44] In eligible eyes, after keratometric values were measured, one topographic image was obtained through a dilated pupil (by using tropicamide 1%, Alcon, Fort Worth, Texas, USA). This is in contrast to the standard protocol of 3 images recommended usually.…”

Section: Ocular Perfusion Measurementsmentioning

confidence: 99%

First-line therapy with latanoprost 0.005% results in improved ocular circulation in newly diagnosed primary open-angle glaucoma patients: a prospective, 6-month, open-label study

Gherghel

Hosking

Cunliffe

et al. 2006

Eye

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Purpose To evaluate the effect of latanoprost 0.005% on the optic nerve head (ONH) and retinal circulation of newly diagnosed and previously untreated primary open-angle glaucoma (POAG) patients. Methods Twenty-two newly diagnosed and previously untreated POAG patients (mean age7SD: 68.38711.92 years) were included in this longitudinal open-label study. Patients were treated with latanoprost 0.005% once a day. Intraocular pressure (IOP), systemic blood pressure (BP), mean ocular perfusion pressure (MOPP), and ocular perfusion parameters 'volume', 'velocity', and 'flow' measured at the optic nerve head (ONH) and retina by means of Heidelberg Retina Flowmeter system were evaluated during a 6-month follow-up period. Results Treatment with latanoprost 0.005% resulted in a significant decrease in IOP (Po0.0001) and increase in MOPP (Po0.0001). After correcting for changes in MOPP, the blood velocity measured at the ONH level was significantly higher after 6 months of treatment than at baseline (P ¼ 0.0310). In addition, blood volume and flow measured at the peripapillary retina level improved after 3 and 6 months of treatment (P ¼ 0.0170; P ¼ 0.0260, and P ¼ 0.0170; P ¼ 0.0240 respectively).Conclusion Previously untreated POAG patients exhibit reduced IOP, increased MOPP and improved ocular perfusion at the ONH and retina levels when treated with Latanoprost 0.005%. These effects could be beneficial for glaucoma patients suffering from ocular vascular dysregulation.

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Section: Ocular Perfusion Measurementsmentioning

confidence: 99%

First-line therapy with latanoprost 0.005% results in improved ocular circulation in newly diagnosed primary open-angle glaucoma patients: a prospective, 6-month, open-label study

Gherghel

Hosking

Cunliffe

et al. 2006

Eye

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“…Heidelberg Retina Tomograph optic disc images (Burk et al 1990(Burk et al , 1993 have been acquired in a large portion of patients with a clinical diagnosis of glaucoma, suspected glaucoma, and ocular hypertension at our department. Thus, HRT images were available for 472 eyes of 302 patients.…”

Section: Glaucoma Groupmentioning

confidence: 99%

Comparison of ranked segment analysis (RSA) and cup to disc ratio in computer‐assisted optic disc evaluation

Gundersen

Åsman

2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: Ranked segment analysis is a new method for evaluation of optic nerve head topography with the Heidelberg Retina Tomograph. This analysis ranks sector measurements around the optic disc and compares these measurements with rank specific significance limits. We evaluated the diagnostic precision of the ranked segment analysis in a large clinical sample and compared with vertical cup/disc ratio measurements. Vertical cup/disc ratio measurements were not corrected for disc size. Methods: We analysed optic disc images from 153 normal and 75 glaucomatous eyes using the Heidelberg Retina Tomograph (software version 2.01). Ranked segment analyses and vertical cup/disc ratio measurements were obtained from each optic disc image, and ROC curves were plotted. Results: At the 95% specificity level, sensitivity was significantly lower for ranked segment analysis (70%) compared to vertical cup/disc ratio measurements (85%). Almost 30% of the discs in the glaucoma group were classified as normal using the ranked segment analysis. Discussion: Ranked segment analysis yielded unacceptably poor discrimination, in fact, worse than cup/disc ratio with its known clinical limitations. Glaucomatous disc damage typically occurs at the vertical poles of the disc. High rank measurements (low sector values) in normal eyes, on the other hand, are more common in the temporal disc sectors. Important spatial information is lost during the ranking procedure. This may partly explain the low sensitivity of the ranked segment analysis observed in our study. The results raise serious concerns regarding the clinical usefulness of ranked segment analysis.Key words: ranked segment analysis -glaucoma diagnosis -diagnostic precision -optic nerve head -image analysis -sensitivity and specificity.

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“…29 There are several limitations to the use of planimetry for measuring disk size. It is a timeconsuming technique, and also depends upon the subjective judgment of the edge of the optic disk.…”

Section: Planimetrymentioning

confidence: 99%

Optic Disk Size and Glaucoma

Hoffmann

Zangwill

Crowston

et al. 2007

Survey of Ophthalmology

138

111

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Assessment of optic disk size is an important, but often overlooked, component of the diagnostic evaluation for glaucoma. Measured values of optic disk size vary with the measurement technique utilized. Available methods for disk size measurement and their respective strengths and limitations will be discussed. Further, actual disk size varies with race and possibly other demographic characteristics. Disk size is also associated with variation of specific anatomical structures of the optic nerve head and the retinal nerve fiber layer. These disk size-dependent variations may influence the susceptibility to glaucoma or the likelihood of glaucoma diagnosis. This manuscript reviews the published evidence relating to disk size and glaucoma.

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Laser scanning tomography and stereophotogrammetry in three-dimensional optic disc analysis

Cited by 46 publications

References 17 publications

First-line therapy with latanoprost 0.005% results in improved ocular circulation in newly diagnosed primary open-angle glaucoma patients: a prospective, 6-month, open-label study

First-line therapy with latanoprost 0.005% results in improved ocular circulation in newly diagnosed primary open-angle glaucoma patients: a prospective, 6-month, open-label study

Comparison of ranked segment analysis (RSA) and cup to disc ratio in computer‐assisted optic disc evaluation

Optic Disk Size and Glaucoma

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