Optic Disk Size and Glaucoma

Hoffmann, Esther M.; Zangwill, Linda M.; Crowston, Jonathan G; Weinreb, Robert N.

doi:10.1016/j.survophthal.2006.10.002

Cited by 142 publications

(125 citation statements)

References 169 publications

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“…Large discs have large total lamina cribrosa area and more lamina pores than small discs. These pores allow more space for nerve fibers to travel through, and therefore, they reduce risk of compression to the optic nerve axons (21). On the other hand, pressure differential across the lamina cribrosa can produce an increased deformation and displacement of the central tissue in macrodiscs, leading to greater glaucoma susceptibility in these eyes (22,23).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Corneal Biomechanical Properties Betweeen Physiological Macrodiscs and Glaucomatous Macrodiscs

Onmez¹

2017

Beyoglu Eye J

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Objectives:This study was designed to compare optic nerve head (ONH) parameters and corneal biomechanical properties of healthy and glaucomatous macrodiscs. Methods: This cross-sectional study included total of 234 eyes, of which 92 served as normal controls, 92 had healthy macrodiscs, and 50 had glaucomatous macrodiscs. Measurement of ONH parameters in all p¬atients was performed using optic coherence tomography (OCT). Corneal hysteresis (CH) was measured in each patient using Ocular Response Analyzer (ORA; Reichert, Inc., Depew, NY, USA). Central corneal thickness (CCT) was determined by ultrasonic pachymetry. All OCT and ORA parameters of healthy and glaucomatous macrodiscs were compared. Results: Optic disc area of healthy macrodiscs and glaucomatous macrodiscs was similar, and larger than observed in control group (p=0.70, p=0.0001, respectively). Rim area was significantly thinner in glaucoma group than healthy macrodisc group or control group. (p=0.0001, p=0.022, respectively) Mean cup area of glaucomatous discs was larger than healthy macrodiscs (p=0.001). Cup/disc (C/D) area ratio, and horizontal and vertical C/D ratios were higher in glaucoma group than healthy macrodisc group (p=0.002, p=0.002, p=0.018, respectively) ORA analyses revealed that CH of glaucoma patients was lower than that of healthy macrodisc or control group (p=0.048, p=0.035, respectively), whereas, mean CH of macrodisc group was similar to that of control group (p=0.988). Mean CCT of macrodisc group was higher than that observed in control or glaucoma patients (p=0.015, p=0.045). Conclusion: It was concluded that OCT analyses can help differentiate healthy macrodiscs from glaucomatous discs. CH and corneal thickness measurements of healthy macrodiscs are greater than those of glaucomatous optic discs.

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Section: Discussionmentioning

confidence: 99%

Comparison of Corneal Biomechanical Properties Betweeen Physiological Macrodiscs and Glaucomatous Macrodiscs

Onmez¹

2017

Beyoglu Eye J

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“…It can be difficult to determine the borders of the optic disc in individuals with high myopia and eyes with significant PPA. [20][21][22][23][24][25] It is critical to first correctly estimate the size of the optic disc when investigating for glaucoma. Measurement of optic disc size is best performed at the slit lamp using a narrow vertical light beam and a condensing fundus lens.…”

Section: Optic Disc Size Color and Shapementioning

confidence: 99%

“…[1][2][3][4][5][6]12,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] Pale cupping (pallor exceeding cupping) indicates a non-GON, such as anterior ischemic optic neuropathy (AION), compressional lesion to the optic nerve (tumor or hemorrhage), secondary optic atrophies due to papilledema, and inflammatory and infectious optic neuropathies. [1][2][3][4][5][6]12,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] Non-glaucomatous cupping can occur in AION, optic nerve compression (optic nerve tumour or hemorrhage), contusion, inflammation, and trauma of optic nerve, and hereditary optic neuropathies. In contrast to GON, in which the optic cup deepens and enlarges as associated with the glaucoma type and the level of intraocular pressure (IOP), the optic cup does not show significant enlargement in eyes with non-GON.…”

Section: Optic Disc Size Color and Shapementioning

confidence: 99%

Pearls for Correct Assessment of Optic Disc at Glaucoma Diagnosis

Turgut¹

2017

US Ophthalmic Review

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The correct evaluation of the optic disc, and related structures in ophthalmoscopy, is critical for the diagnosis of open angle glaucoma because usually glaucomatous optic nerve damage firstly occurs in the optic disc before detectable visual field defects become apparent; however, some studies have demonstrated that visual field defects can also be found without any glaucomatous changes in the optic disc. The purpose of this review is to provide a guide to clinicians for the evaluation of the optic disc in glaucoma suspects and patients. This guide can facilitate the diagnosis and exclusion of glaucoma in these subjects.

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“…Disk size evaluation is an important part of optic disk assessment to diagnose glaucoma, in addition to features such as neuroretinal rim and cup area. But it should be considered that the patient characteristics and the measurement method may affect the disk size estimates [3].…”

Section: Introductionmentioning

confidence: 99%