Laser Processing of Electrospun PCL Fiber Mats for Tissue Engineering

Zernetsch, Holger; Kern, Alexander; Jäschke, Peter; Glasmacher, Birgit

doi:10.5301/ijao.5000455

Cited by 8 publications

(4 citation statements)

References 22 publications

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“…The welded mat of carbon nanofibers showed significantly higher mechanical strength and lower electrical resistance than the pristine mat . In addition to direct heating, photothermal heating has also been used to initiate the welding when photothermal dyes or nanoparticles (e.g., Au and Ag nanostructures) are doped in the nanofibers . For example, upon laser irradiation at a power of 2–10 mW, the cross-points of PVDF nanofibers doping with Ag nanoparticles were successfully welded as the Ag nanoparticles absorbed photons and then transferred heat to the surrounding polymer matrix efficiently. , …”

Section: Electrospinningmentioning

confidence: 99%

Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

et al. 2019

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Electrospinning is a versatile and viable technique for generating ultrathin fibers. Remarkable progress has been made with regard to the development of electrospinning methods and engineering of electrospun nanofibers to suit or enable various applications. We aim to provide a comprehensive overview of electrospinning, including the principle, methods, materials, and applications. We begin with a brief introduction to the early history of electrospinning, followed by discussion of its principle and typical apparatus. We then discuss its renaissance over the past two decades as a powerful technology for the production of nanofibers with diversified compositions, structures, and properties. Afterward, we discuss the applications of electrospun nanofibers, including their use as “smart” mats, filtration membranes, catalytic supports, energy harvesting/conversion/storage components, and photonic and electronic devices, as well as biomedical scaffolds. We highlight the most relevant and recent advances related to the applications of electrospun nanofibers by focusing on the most representative examples. We also offer perspectives on the challenges, opportunities, and new directions for future development. At the end, we discuss approaches to the scale-up production of electrospun nanofibers and briefly discuss various types of commercial products based on electrospun nanofibers that have found widespread use in our everyday life.

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Section: Electrospinningmentioning

confidence: 99%

Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

et al. 2019

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“…The development of bioartificial tissues and devices has attracted a large number of investigators over the last two decades, and this is reflected by important contributions in our journal (28)(29)(30)(31). The aim is to add biological functions to artificial organs and tissues that cannot be obtained by completely artificial systems.…”

Section: Tissue Engineering Bioartificial Organs and Regenerative Med...mentioning

confidence: 99%

Updating the Journal Sections for the Evolution of Research and Clinical Applications in Artificial Organs

Remuzzi

2016

Int J Artif Organs

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“…[13] Injectable laser-manufactured micro-scaffolds, for example, were shown to promote cell proliferation ex vivo. [14] Besides cutting and welding, [15,16] laser irradiation can be used to achieve different modifications of the surface morphology [17] and surface chemistry. [18] Cell adhesion is strongly affected by the nanofiber morphology of the tissue.…”

Section: Introductionmentioning

confidence: 99%

Laser Structuring of Polyamide Nanofiber Nonwoven Surfaces and Their Influence on Cell Adhesion

Michler

Götze

Kürbitz

et al. 2022

Macro Materials & Eng

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Electrospun nonwovens have great potential for biomedical applications. They can be used, for example, to mimic the structure of the extracellular matrix of biological tissue. In this work, it is demonstrated that the surface properties of nanofiber nonwovens made of biocompatible and very slowly biodegrading polyamide can be modified by UV picosecond laser processing. Basically, the nanofiber structure is only slightly changed by the corresponding laser process. Significant laser‐induced material change occurs only along narrow lines determined by the scanning process. The newly formed surface structures resemble a bulk surface. It is shown that the growth of mammalian chondrocyte cells (SW1353) is initially more effective on the laser‐processed surface. Cell growth occurs preferably along the laser‐generated lines. After several days of cell growth, an extended layer of cells is formed over the laser‐modified and unmodified surface sections. Thus, laser‐based surface modification provides another tool to affect cell proliferation on polyamide nanofiber nonwovens.

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Laser Processing of Electrospun PCL Fiber Mats for Tissue Engineering

Abstract: A first proof of concept for a heart valve-shaped scaffold was created by laser bonding. Thus, the laser is an advantageous tool for post-processing fiber mats and produce complex 3D structures for different applications.

Cited by 8 publications

References 22 publications

Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

Updating the Journal Sections for the Evolution of Research and Clinical Applications in Artificial Organs

Laser Structuring of Polyamide Nanofiber Nonwoven Surfaces and Their Influence on Cell Adhesion

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