Laser-patterned paper-based sensors for rapid point-of-care detection and antibiotic-resistance testing of bacterial infections

He, Peijun; Katis, Ioannis; Kumar, A.J.U.; Bryant, Catherine; Keevil, C. W.; Somani, Bhaskar K.; Mahobia, Nitin; Eason, R.W.; Sones, C.L.

doi:10.1016/j.bios.2020.112008

Cited by 37 publications

(19 citation statements)

References 40 publications

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“…Therefore, to control infections caused by AMR bacteria better, He et al developed a laser-patterned μ PAD for the detection and susceptibility testing of E. coli via a simple visualized color change in resource-poor regions ( Fig. 18 C) [403] . The results indicated the μ PAD a promising device for POC detection of bacterial infections, providing a novel tool for tackling the global challenge of AMR.…”

Section: Poc Devices For Infectious Disease Detectionmentioning

confidence: 99%

Point-of-care diagnostics for infectious diseases: From methods to devices

et al. 2021

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Section: Poc Devices For Infectious Disease Detectionmentioning

confidence: 99%

Point-of-care diagnostics for infectious diseases: From methods to devices

et al. 2021

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“…Recently, He et al reported a laser-pattern paper-based microfluidic device capable of performing E. coli identification and susceptibility testing via visual observation of a simple color change (colorimetric readout). Such a micro-device is suitable for low resource settings and can be used by minimally trained personnel [170].…”

Section: Ph-based Approachesmentioning

confidence: 99%

Rapid Methods for Antimicrobial Resistance Diagnostics

et al. 2021

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Antimicrobial resistance (AMR) is one of the most challenging threats in public health; thus, there is a growing demand for methods and technologies that enable rapid antimicrobial susceptibility testing (AST). The conventional methods and technologies addressing AMR diagnostics and AST employed in clinical microbiology are tedious, with high turnaround times (TAT), and are usually expensive. As a result, empirical antimicrobial therapies are prescribed leading to AMR spread, which in turn causes higher mortality rates and increased healthcare costs. This review describes the developments in current cutting-edge methods and technologies, organized by key enabling research domains, towards fighting the looming AMR menace by employing recent advances in AMR diagnostic tools. First, we summarize the conventional methods addressing AMR detection, surveillance, and AST. Thereafter, we examine more recent non-conventional methods and the advancements in each field, including whole genome sequencing (WGS), matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) spectrometry, Fourier transform infrared (FTIR) spectroscopy, and microfluidics technology. Following, we provide examples of commercially available diagnostic platforms for AST. Finally, perspectives on the implementation of emerging concepts towards developing paradigm-changing technologies and methodologies for AMR diagnostics are discussed.

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“…Membrane filtration is a physical separation method based on differences in the size of molecules. Since membrane filtration is economical and does not require specialized skills, it has been employed in various fields [ 62 , 63 ]. Conventional membrane filtration methods are not target-specific because separation is achieved only by size differences.…”

Section: Isolation Of Target Bacteria–mnp Complexes From Free Mnpsmentioning

confidence: 99%

Recent advances in magnetic nanoparticle-based microfluidic devices for the pretreatment of pathogenic bacteria

et al. 2021

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Rapid and sensitive detection of pathogenic bacteria in various samples, including food and drinking water, is important to prevent bacterial diseases. Most bacterial solutions contain only a small number of bacteria in complex matrices with impurities; hence, pretreatment is necessary to separate and concentrate target bacteria before sensing. Among various pretreatment methods, iron oxide magnetic nanoparticle (MNP)-based pretreatment has drawn attention owing to the unique properties of MNP, such as high magnetic susceptibility, superparamagnetism, and biocompatibility. After target bacteria are captured by recognition molecule-functionalized MNPs, bacteria–MNP complexes can be easily separated and enriched by applying an external magnetic field. Various devices, such as optical, electrochemical, and magnetoresistance sensors, can be used to detect target bacteria, and their detection principles have been discussed in numerous review papers. Herein, we focus on recent research advances and challenges in magnetic pretreatment of pathogenic bacteria using microfluidic devices, which offer the advantages of process automation and miniaturization.

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Laser-patterned paper-based sensors for rapid point-of-care detection and antibiotic-resistance testing of bacterial infections

Cited by 37 publications

References 40 publications

Point-of-care diagnostics for infectious diseases: From methods to devices

Point-of-care diagnostics for infectious diseases: From methods to devices

Rapid Methods for Antimicrobial Resistance Diagnostics

Recent advances in magnetic nanoparticle-based microfluidic devices for the pretreatment of pathogenic bacteria

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