Laser-induced breakdown spectroscopy for human and animal health: A review

Gaudiuso, R.; Melikechi, Noureddine; Abdel‐Salam, Zienab; Harith, M. A.; Palleschi, Vincenzo; Motto-Ros, Vincent; Busser, Benoît

doi:10.1016/j.sab.2018.11.006

Cited by 112 publications

(46 citation statements)

References 195 publications

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“…In the past few years, the LIBS application to microscopic elemental imaging has undergone developments both in terms of instrumentation and methodology [ 62 , 207 , 208 ]. In LIBS imaging, laser-induced plasmas are generated at different positions of the sample surface with a predefined sequence covering the area of interest.…”

Section: Laser-induced Breakdown Spectroscopy (Libs)mentioning

confidence: 99%

Short-Pulse Lasers: A Versatile Tool in Creating Novel Nano-/Micro-Structures and Compositional Analysis for Healthcare and Wellbeing Challenges

et al. 2021

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Driven by flexibility, precision, repeatability and eco-friendliness, laser-based technologies have attracted great interest to engineer or to analyze materials in various fields including energy, environment, biology and medicine. A major advantage of laser processing relies on the ability to directly structure matter at different scales and to prepare novel materials with unique physical and chemical properties. It is also a contact-free approach that makes it possible to work in inert or reactive liquid or gaseous environment. This leads today to a unique opportunity for designing, fabricating and even analyzing novel complex bio-systems. To illustrate this potential, in this paper, we gather our recent research on four types of laser-based methods relevant for nano-/micro-scale applications. First, we present and discuss pulsed laser ablation in liquid, exploited today for synthetizing ultraclean “bare” nanoparticles attractive for medicine and tissue engineering applications. Second, we discuss robust methods for rapid surface and bulk machining (subtractive manufacturing) at different scales by laser ablation. Among them, the microsphere-assisted laser surface engineering is detailed for its appropriateness to design structured substrates with hierarchically periodic patterns at nano-/micro-scale without chemical treatments. Third, we address the laser-induced forward transfer, a technology based on direct laser printing, to transfer and assemble a multitude of materials (additive structuring), including biological moiety without alteration of functionality. Finally, the fourth method is about chemical analysis: we present the potential of laser-induced breakdown spectroscopy, providing a unique tool for contact-free and space-resolved elemental analysis of organic materials. Overall, we present and discuss the prospect and complementarity of emerging reliable laser technologies, to address challenges in materials’ preparation relevant for the development of innovative multi-scale and multi-material platforms for bio-applications.

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Section: Laser-induced Breakdown Spectroscopy (Libs)mentioning

confidence: 99%

Short-Pulse Lasers: A Versatile Tool in Creating Novel Nano-/Micro-Structures and Compositional Analysis for Healthcare and Wellbeing Challenges

et al. 2021

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“…L'analyse élémentaire LIBS est applicable sur des échantillons solides, liquides ou gazeux et se réalise à température et pression ambiantes [8]. C'est une technique simple, rapide, peu dommageable pour l'échantillon, et qui permet une analyse de l'ensemble des éléments avec une seule impulsion laser.…”

Section: Les Avantages De L'imagerie Libsunclassified

“…Une analyse LIBS a été réalisée sur les tissus cicatriciels. Les images multi-élémentaires LIBS ont révélé la présence d'un taux élevé de titane, en plus de la présence de cuivre et de particules localisées de tungstène (W) ou de chrome (Cr), confirmant la présence de débris métalliques résultant de l'acte chirurgical ( Figure C panneau de [8]. Les informations collectées sont directement issues de mesures réalisées au sein du tissu et analysées de façon semi-quantitative.…”

Section: Particules Exogènes Post-chirurgicalesunclassified

L’imagerie élémentaire par spectroscopie LIBS

et al. 2019

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L’imagerie multi-élémentaire des tissus biologiques grâce à la spectroscopie LIBS (laser-induced breakdown spectroscopy) permet la visualisation directe de la distribution des éléments endogènes ou exogènes. Cette technologie est notamment utilisée pour mettre en image la cinétique des nanoparticules métalliques dans les organes d’élimination, mais également pour analyser la distribution physiologique des éléments biologiques in situ, et pour révéler la topographie des éléments chimiques, comme les métaux, dans des tissus humains qui ont été exposés à des agents extérieurs potentiellement toxiques. Fondée sur notre expérience et les travaux les plus récents dans le domaine de l’imagerie du contenu élémentaire des tissus animaux et humains, cette revue décrit les principes et les caractéristiques de l’instrumentation LIBS, présente certains aspects techniques pour mettre en place des expériences avec cet outil, montre les avantages et les limites de cette technologie, et s’intéresse aux différentes possibilités qu’offre l’imagerie LIBS pour des applications précliniques et médicales.

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“…Nowadays, the available commercial mobile or portable LIBS systems facilitate in situ and real‐time measurements 18,19 . LIBS has been exploited successfully in numerous applications, to mention some, industrial, 20 geochemical, 21,22 archeological, 23,24 biological, 25,26 medical, 27,28 forensic, 29–32 and agricultural 33,34 …”

Section: Introductionmentioning

confidence: 99%

Laser‐induced breakdown spectroscopy and chemometric analysis of black toners for forensic applications

Ahmed

Abdel‐Hamid

Abdel‐Salam

et al. 2021

Journal of Chemometrics

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In the present work, laser‐induced breakdown spectroscopy (LIBS) was used to differentiate between different black toners of printers and photocopiers based on their elemental composition. Measurements were performed on 23 toner samples of different printers and six different photocopiers (of different brands and models). The LIBS spectra were compared to characterize each toner type. Multivariate statistical analysis based on PCA and graph clustering was used to develop a discrimination model between the toners in questioned documents. Good discrimination of both brand and model toners was obtained. The results may be beneficial for forensic applications in the investigations of questioned documents.

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Laser-induced breakdown spectroscopy for human and animal health: A review

Cited by 112 publications

References 195 publications

Short-Pulse Lasers: A Versatile Tool in Creating Novel Nano-/Micro-Structures and Compositional Analysis for Healthcare and Wellbeing Challenges

Short-Pulse Lasers: A Versatile Tool in Creating Novel Nano-/Micro-Structures and Compositional Analysis for Healthcare and Wellbeing Challenges

L’imagerie élémentaire par spectroscopie LIBS

Laser‐induced breakdown spectroscopy and chemometric analysis of black toners for forensic applications

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