Laser flare-cell photometry: methodology and clinical applications

Ladas, John G.; Wheeler, Noel C.; Morhun, Patrick J.; Rimmer, Steven; Holland, Gary N.

doi:10.1016/j.survophthal.2004.10.004

Cited by 161 publications

(136 citation statements)

References 46 publications

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“…The slit width was 0-11 mm and was continuously available. 9,10 OCULUS Pentacam (Oculus, Inc.) images were obtained under pupil dilatation with 1% tropicamide. To reduce operator-dependent variables, Pentacam's automatic release mode was used.…”

Section: Flaremeter Kowa Fm-700mentioning

confidence: 99%

“…8 In the 1980s, the KOWA Company (Tokyo, Japan) developed techniques to quantify the amount of proteins in the AC noninvasively using a scanning laser. 9 The laser flare photometry provided an accurate, reproducible and non-invasive assessment of aqueous flare that could prove valuable in research and clinical decisions. 10 The aim of this study was to assess the AC characteristics and its correlation to the laser flare photometry immediately after femtosecond laser-assisted capsulotomy and photodisruption; the idea was to identify structural changes that were likely to lead to corneal reactions and increases in intraocular inflammation in some patients, while most patients did not suffer from side effects.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between anterior chamber characteristics and laser flare photometry immediately after femtosecond laser treatment before phacoemulsification

Torun

Pahlitzsch

Klamann

et al. 2016

Eye

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Purpose To assess the anterior chamber (AC) characteristics and its correlation to laser flare photometry immediately after femtosecond laser-assisted capsulotomy and photodisruption.Patients and methods The study included 97 cataract eyes (n = 97, mean age 68.6 years) undergoing femtosecond laser-assisted cataract surgery (FLACS). Three cohorts were analysed relating to the flare photometry directly post femtosecond laser treatment (flare o100 n = 28, 69.6 ± 7 years; flare 100-249 n = 47, 67.7 ± 8 years; flare 4249 photon counts per ms cohort n = 22, 68.5 ± 10 years). Flare photometry (KOWA FM-700), corneal topography (Oculus Pentacam, Germany: AC depth, volume, angle, pachymetry), axial length, pupil diameter, and endothelial cells were assessed before FLACS, immediately after femtosecond laser treatment and 1 day postoperative (LenSx Alcon, USA). Statistical data were analysed by SPSS v19.0, Inc. Results The AC depth, AC volume, AC angle, central and thinnest corneal thickness showed a significant difference between flare o100 vs flare 100-249 10 min post femtosecond laser procedure (P = 0.002, P = 0.023, P = 0.007, P = 0.003, P = 0.011, respectively). The AC depth, AC volume, and AC angle were significantly larger (P = 0.001, P = 0.007, P = 0.003, respectively) in the flare o100 vs flare 4249 cohort 10 min post femtosecond laser treatment. Conclusions A flat AC, low AC volume, and a narrow AC angle were parameters associated with higher intraocular inflammation. These criteria could be used for patient selection in FLACS to reduce postoperative intraocular inflammation.

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Section: Flaremeter Kowa Fm-700mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation between anterior chamber characteristics and laser flare photometry immediately after femtosecond laser treatment before phacoemulsification

Torun

Pahlitzsch

Klamann

et al. 2016

Eye

View full text Add to dashboard Cite

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“…To quantify the severity of inflammatory response, standard grading systems were used (Hogan et al, 1959;Nussenblatt et al, 1985;Ladas et al, 2005). To document fundus appearance, fundus photographs (using an infrared camera to avoid excess visible light exposure) were taken at baseline and at posttreatment visits.…”

Section: Safety Parametersmentioning

confidence: 99%

Treatment of Leber Congenital Amaurosis Due toRPE65Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

et al. 2008

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Leber congenital amaurosis (LCA) is a group of autosomal recessive blinding retinal diseases that are incurable. One molecular form is caused by mutations in the RPE65 (retinal pigment epithelium-specific 65-kDa) gene. A recombinant adeno-associated virus serotype 2 (rAAV2) vector, altered to carry the human RPE65 gene (rAAV2-CB SB -hRPE65), restored vision in animal models with RPE65 deficiency. A clinical trial was designed to assess the safety of rAAV2-CB SB -hRPE65 in subjects with RPE65-LCA. Three young adults (ages 21-24 years) with RPE65-LCA received a uniocular subretinal injection of 5.96 ϫ 10 10 vector genomes in 150 l and were studied with follow-up examinations for 90 days. Ocular safety, the primary outcome, was assessed by clinical eye examination. Visual function was measured by visual acuity and dark-adapted full-field sensitivity testing (FST); central retinal structure was monitored by optical coherence tomography (OCT). Neither vector-related serious adverse events nor systemic toxicities were detected. Visual acuity was not significantly different from baseline; one patient showed retinal thinning at the fovea by OCT. All patients self-reported increased visual sensitivity in the study eye compared with their control eye, especially noticeable under reduced ambient light conditions. The dark-adapted FST results were compared between baseline and 30-90 days after treatment. For study eyes, sensitivity increases from mean baseline were highly significant (p Ͻ 0.001); whereas, for control eyes, sensitivity changes were not significant (p ϭ 0.99). Comparisons are drawn between the present work and two other studies of ocular gene therapy for RPE65-LCA that were carried out contemporaneously and reported. 979

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“…There are several ways to quantify the aqueous cells, including slit-lamp biomicroscopy (Jabs et al, 2005), ultrasound biomicroscopy (UBM) (Peizeng et al, 2009), laser flare photometry (Ladas et al, 2005) and optical coherence tomography (OCT) (Agarwal et al, 2009;Igbre et al, 2014;Kumar et al, 2014;Li et al, 2013;Sharma et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Secondly, it provides objective images compared to slit-lamp biomicroscopy (Kumar et al, 2014). Thirdly, it can be used in patients with corneal opacity compared to laser flare photometry (Ladas et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Comparison of time-domain, spectral-domain and swept-source OCT in evaluating aqueous cells in vitro

Wang

Liu

et al. 2016

Sci. China Life Sci.

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Laser flare-cell photometry: methodology and clinical applications

Cited by 161 publications

References 46 publications

Correlation between anterior chamber characteristics and laser flare photometry immediately after femtosecond laser treatment before phacoemulsification

Correlation between anterior chamber characteristics and laser flare photometry immediately after femtosecond laser treatment before phacoemulsification

Treatment of Leber Congenital Amaurosis Due toRPE65Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

Comparison of time-domain, spectral-domain and swept-source OCT in evaluating aqueous cells in vitro

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