Laser emitted radiant heat for pain research

Mor, J.; Carmon, Amiram

doi:10.1016/0304-3959(75)90040-8

Cited by 144 publications

(42 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, application of heat stimuli through thermodes reduces nonpain sensations typically elicited with application of electrical stimulation (Angst et al, 2009;Reddy et al, 2012). Onset and termination of heat stimuli using a conductive thermode is also easier to control than radiant heat that takes time to terminate (Arendt-Nielsen and Bjerring, 1988;Mor and Carmon, 1975). Finally, the distal forearm was chosen for stimulus application because it is contralateral to the right hemisphere-the site of anodal tDCS.…”

Section: Methodsmentioning

confidence: 99%

Transcranial Direct Current Stimulation Targeting Primary Motor Versus Dorsolateral Prefrontal Cortices: Proof-of-Concept Study Investigating Functional Connectivity of Thalamocortical Networks Specific to Sensory-Affective Information Processing

et al. 2017

View full text Add to dashboard Cite

The pain matrix is comprised of an extensive network of brain structures involved in sensory and/or affective information processing. The thalamus is a key structure constituting the pain matrix. The thalamus serves as a relay center receiving information from multiple ascending pathways and relating information to and from multiple cortical areas. However, it is unknown how thalamocortical networks specific to sensory-affective information processing are functionally integrated. Here, in a proof-of-concept study in healthy humans, we aimed to understand this connectivity using transcranial direct current stimulation (tDCS) targeting primary motor (M1) or dorsolateral prefrontal cortices (DLPFC). We compared changes in functional connectivity (FC) with DLPFC tDCS to changes in FC with M1 tDCS. FC changes were also compared to further investigate its relation with individual's baseline experience of pain. We hypothesized that resting-state FC would change based on tDCS location and would represent known thalamocortical networks. Ten right-handed individuals received a single application of anodal tDCS (1 mA, 20 min) to right M1 and DLPFC in a single-blind, shamcontrolled crossover study. FC changes were studied between ventroposterolateral (VPL), the sensory nucleus of thalamus, and cortical areas involved in sensory information processing and between medial dorsal (MD), the affective nucleus, and cortical areas involved in affective information processing. Individual's perception of pain at baseline was assessed using cutaneous heat pain stimuli. We found that anodal M1 tDCS and anodal DLPFC tDCS both increased FC between VPL and sensorimotor cortices, although FC effects were greater with M1 tDCS. Similarly, anodal M1 tDCS and anodal DLPFC tDCS both increased FC between MD and motor cortices, but only DLPFC tDCS modulated FC between MD and affective cortices, like DLPFC. Our findings suggest that M1 stimulation primarily modulates FC of sensory networks, whereas DLPFC stimulation modulates FC of both sensory and affective networks. Our findings when replicated in a larger group of individuals could provide useful evidence that may inform future studies on pain to differentiate between effects of M1 and DLPFC stimulation. Notably, our finding that individuals with high baseline pain thresholds experience greater FC changes with DLPFC tDCS implies the role of DLPFC in pain modulation, particularly pain tolerance.

show abstract

Section: Methodsmentioning

confidence: 99%

Transcranial Direct Current Stimulation Targeting Primary Motor Versus Dorsolateral Prefrontal Cortices: Proof-of-Concept Study Investigating Functional Connectivity of Thalamocortical Networks Specific to Sensory-Affective Information Processing

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Extracellular units that were either excited or inhibited by this pinch stimulus were studied. The neuronal response to noxious heat was assessed using a CO 2 laser similar to the one described by Mor and Carmon (1975). The laser stimulus was a brief fixed pulse (140 -150 msec, 5 W) that heated a very small (ϳ1.0 mm diameter) spot of skin at an average of Ͼ75.0°C/sec (Haimi-Cohen et al, 1983).…”

Section: Experimental Protocolmentioning

confidence: 99%

“…The present study compares the timing of RM cellular responses and the motor reaction evoked by a laser heat stimulus. Precise latency determination can be made using laser stimulation because the skin is heated in a short time (Յ150 msec), thereby producing nearly synchronous activation of peripheral afferents (Mor and Carmon, 1975;Le Bars et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Discharge of Raphe Magnus on and offCells Is Predictive of the Motor Facilitation Evoked by Repeated Laser Stimulation

Foo

Mason

2003

J. Neurosci.

View full text Add to dashboard Cite

Medullary raphe magnus (RM) ON and OFF cells are thought to modulate spinal nociception by gating withdrawals evoked by noxious stimulation. To test whether withdrawal initiation is the target of RM modulation, we examined the relationship between ON and OFF cell discharge and motor withdrawal evoked by noxious laser heat in halothane-anesthetized rats. The cellular responses of both cell types began during the 50 msec after onset of the tail flick, peaked within 200 msec, and outlasted the duration of the motor reaction. Thus, it is unlikely that the target of ON and OFF cell modulation is withdrawal initiation; instead, ON and OFF cells may modulate reactions to repeated noxious stimulation. We therefore tested whether laser heat-evoked changes in RM cell discharge were predictive of the modulatory effects of one noxious stimulus on the reaction to a subsequent noxious stimulus. Two pulses of laser heat were presented at interpulse intervals of 0.8, 2.0, or 10.0 sec. The motor withdrawal evoked by the second pulse was significantly enhanced relative to that evoked by the first pulse. The observed motor enhancement depended on supraspinal input because it was not present in spinalized rats. Comparison of the relative changes in motor and cellular activity preceding double laser heat stimulation revealed parallel changes between motor facilitation, decreases in OFF cell discharge, and increases in ON cell discharge. This finding suggests a preparatory role for RM ON and OFF cells in enhancing reactions to a noxious stimulus that closely follows another noxious stimulus.

show abstract

“…This is probably related to regional blood flow and can introduce errors in the measurement. A recent improvement in this field has been the introduction of infrared laser beam stimulation (Mor & Carmon 1975). This method shortens the exposure time required for thermal noxious stimulation to a few milliseconds, avoiding coactivation of non-noxious thermoreceptors.…”

Section: Journal Of the Royal Society Of Medicine Volume 76 May 1983 4jjmentioning

confidence: 99%

Physical Methods used in Pain Measurements: A Review

Campbell

Lahuerta

1983

J R Soc Med

View full text Add to dashboard Cite

Laser emitted radiant heat for pain research

Cited by 144 publications

References 1 publication

Transcranial Direct Current Stimulation Targeting Primary Motor Versus Dorsolateral Prefrontal Cortices: Proof-of-Concept Study Investigating Functional Connectivity of Thalamocortical Networks Specific to Sensory-Affective Information Processing

Transcranial Direct Current Stimulation Targeting Primary Motor Versus Dorsolateral Prefrontal Cortices: Proof-of-Concept Study Investigating Functional Connectivity of Thalamocortical Networks Specific to Sensory-Affective Information Processing

Discharge of Raphe Magnus on and offCells Is Predictive of the Motor Facilitation Evoked by Repeated Laser Stimulation

Physical Methods used in Pain Measurements: A Review

Contact Info

Product

Resources

About