Whispering gallery modes (WGMs) have been exploited for a broad range of sensing applications. However, the vast majority of WGM sensors consist of passive resonators, requiring complex interrogation systems to be employed, ultimately limiting their practicality. Active resonators containing a gain medium, allowing remote excitation and collection of the WGM‐modulated fluorescence spectra, have emerged as an alternative to passive resonators. Although research is still in its infancy, recent progress has reduced the performance gap between the two paradigms, fueled by the potential for new applications that could not previously be realized. Here, recent developments in sensors based on active WGM microresonators are reviewed, beginning with a discussion of the theory of fluorescence‐based and lasing WGMs, followed by a discussion of the variety of gain media, resonator architectures, and emerging sensing applications. We conclude with a discussion of the prospects and future directions for improving active WGM sensors.