Optical sensors based on resonant whispering gallery mode (WGM) optical cavities are discussed in the context of recent research developments. WGM-based sensors are among the most sensitive optical sensing devices currently known, especially when combined with surface plasmon effects. The basic theory of WGM "reactive" sensing is first discussed, along with the basic parameters that are used to characterize such devices (i.e., sensitivity, signal-to-noise ratio, and detection limit). Surface chemistry methods are of critical importance for targeted sensing applications and the fundamentals of this aspect are examined. The performance of fluorescent WGM-based devices is compared to state-of-the-art "evanescently-coupled" structures. Finally, the performance of WGM-based optical sensors is compared and contrasted to a range of alternative optical microsensor technologies currently under development.A. François