Laser-Based Fabrication for Microfluidics Devices on Glass for Medical Applications

García, Daniel Nieto; O’Connor, Gerard M.

doi:10.5772/64324

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…The results indicated that the microstructure of the glass microfluidic chip could be fabricated with high surface quality; thus, the method can be applied to the mass production of glass fluidic chips. García et al [ 11 ] presented a laser-based process to fabricate the microstructures on glass for reshaping and improving the morphological and optical qualities for microfluidic applications. Therein, the manufactured chips were used to capture the circulating endometrial tumor cells lines with Hec 1A tested tumor cell after coating the anti-epithelial cell adhesion molecule (EpCAM)antibody.…”

Section: Introductionmentioning

confidence: 99%

Surface Wettability and Electrical Resistance Analysis of Droplets on Indium-Tin-Oxide Glass Fabricated Using an Ultraviolet Laser System

Tsai

Hsu

et al. 2021

Micromachines

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Indium tin oxide (ITO) is widely used as a substrate for fabricating chips because of its optical transparency, favorable chemical stability, and high electrical conductivity. However, the wettability of ITO surface is neutral (the contact angle was approximately 90°) or hydrophilic. For reagent transporting and manipulation in biochip application, the surface wettability of ITO-based chips was modified to the hydrophobic or nearly hydrophobic surface to enable their use with droplets. Due to the above demand, this study used a 355-nm ultraviolet laser to fabricate a comb microstructure on ITO glass to modify the surface wettability characteristics. All of the fabrication patterns with various line width and pitch, depth, and surface roughness were employed. Subsequently, the contact angle (CA) of droplets on the ITO glass was analyzed to examine wettability and electrical performance by using the different voltages applied to the electrode. The proposed approach can succeed in the fabrication of a biochip with suitable comb-microstructure by using the optimal operating voltage and time functions for the catch droplets on ITO glass for precision medicine application. The experiment results indicated that the CA of droplets under a volume of 20 μL on flat ITO substrate was approximately 92° ± 2°; furthermore, due to its lowest surface roughness, the pattern line width and pitch of 110 μm exhibited a smaller CA variation and more favorable spherical droplet morphology, with a side and front view CA of 83° ± 1° and 78.5° ± 2.5°, respectively, while a laser scanning speed of 750 mm/s was employed. Other line width and pitch, as well as scanning speed parameters, increased the surface roughness and resulted in the surface becoming hydrophilic. In addition, to prevent droplet morphology collapse, the droplet’s electric operation voltage and driving time did not exceed 5 V and 20 s, respectively. With this method, the surface modification process can be employed to control the droplet’s CA by adjusting the line width and pitch and the laser scanning speed, especially in the neutral or nearly hydrophobic surface for droplet transporting. This enables the production of a microfluidic chip with a surface that is both light transmittance and has favorable electrical conductivity. In addition, the shape of the microfluidic chip can be directly designed and fabricated using a laser direct writing system on ITO glass, obviating the use of a mask and complicated production processes in biosensing and biomanipulation applications.

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Section: Introductionmentioning

confidence: 99%

Surface Wettability and Electrical Resistance Analysis of Droplets on Indium-Tin-Oxide Glass Fabricated Using an Ultraviolet Laser System

Tsai

Hsu

et al. 2021

Micromachines

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“…65−67 The ability to fabricate surface micropatterns with extreme wetting contrast, for example on polymers or glasses, offers exciting possibilities, 68 in particular, for biomedical and microfluidic applications. 69 Besides polymers, glass is the material of choice 70 because of its chemical inertness, low permeability, and optical transparency. 71 However, a laserbased method for the generation of extreme wetting contrasts on glass substrates has not yet been achieved to the knowledge of the authors.…”

Section: ■ Introductionmentioning

confidence: 99%

Fabrication of Biomimetic Fog-Collecting Superhydrophilic–Superhydrophobic Surface Micropatterns Using Femtosecond Lasers

Kostal¹,

Stroj²,

Kasemann³

et al. 2018

Langmuir

157

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The exciting functionalities of natural superhydrophilic and superhydrophobic surfaces served as inspiration for a variety of biomimetic designs. In particular, the combination of both extreme wetting states to micropatterns opens up interesting applications, as the example of the fog-collecting Namib Desert beetle shows. In this paper, the beetle's elytra were mimicked by a novel three-step fabrication method to increase the fog-collection efficiency of glasses. In the first step, a double-hierarchical surface structure was generated on Pyrex wafers using femtosecond laser structuring, which amplified the intrinsic wetting property of the surface and made it superhydrophilic (water contact angle < 10°). In the second step, a Teflon-like polymer (CF) was deposited by a plasma process that turned the laser-structured surface superhydrophobic (water contact angle> 150°). In the last step, the Teflon-like coating was selectively removed by fs-laser ablation to uncover superhydrophilic spots below the superhydrophobic surface, following the example of the Namib Desert beetle's fog-collecting elytra. To investigate the influence on the fog-collection behavior, (super)hydrophilic, (super)hydrophobic, and low and high contrast wetting patterns were fabricated on glass wafers using selected combinations of these three processing steps and were exposed to fog in an artificial nebulizer setup. This experiment revealed that high-contrast wetting patterns collected the highest amount of fog and enhanced the fog-collection efficiency by nearly 60% compared to pristine Pyrex glass. The comparison of the fog-collection behavior of the six samples showed that the superior fog-collection efficiency of surface patterns with extreme wetting contrast is due to the combination of water attraction and water repellency: the superhydrophilic spots act as drop accumulation areas, whereas the surrounding superhydrophobic areas allow a fast water transportation caused by gravity. The presented method enables a fast and flexible surface functionalization of a broad range of materials including transparent substrates, which offers exciting possibilities for the design of biomedical and microfluidic devices.

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Laser-Based Fabrication for Microfluidics Devices on Glass for Medical Applications

Cited by 2 publications

References 25 publications

Surface Wettability and Electrical Resistance Analysis of Droplets on Indium-Tin-Oxide Glass Fabricated Using an Ultraviolet Laser System

Surface Wettability and Electrical Resistance Analysis of Droplets on Indium-Tin-Oxide Glass Fabricated Using an Ultraviolet Laser System

Fabrication of Biomimetic Fog-Collecting Superhydrophilic–Superhydrophobic Surface Micropatterns Using Femtosecond Lasers

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