Laser angioplasty of arterial stenoses

Geschwind, H; Teisseire, B; Boussignac, Georges; Vieilledent, C.

doi:10.1007/bf02577962

Cited by 13 publications

(2 citation statements)

References 22 publications

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“…Thermal plaque ablation in blood requires less energy than in saline, suggesting that blood may improve the delivery of laser energy to the plaque [13][14][15]. However, positioning metal capped fibers in flowing blood in normal dog coronary arteries lowers the temperature of the laser probe to approximately 50% of the temperature obtained in air [S], which could limit plaque vaporization.…”

Section: Introductionmentioning

confidence: 99%

Effects of blood flow on laser probe temperature in human arteries

et al. 1988

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Laser recanalization using metal capped fibers occurs by thermal vaporization of occluding plaque. However, little is known about the effects of blood and flow on the temperature of the laser probe or the arterial wall during lasing. To study this, probe and arterial wall temperatures were measured while a metal capped fiber, activated by an argon laser, was held stationary in a stenotic human peripheral artery. Arteries were perfused with saline and blood, and flow was varied from 0 to 140 cc/min. Probe temperatures were significantly higher in blood than in saline. However, the increased probe temperature achieved in blood was not transferred to the arterial wall. Increasing flow decreased probe temperature in both media, but again arterial wall temperatures were minimally affected. Thus, the presence of blood and flow may significantly affect heat generation and heat transfer during arterial recanalization using metal capped fibers.

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Section: Introductionmentioning

confidence: 99%

Effects of blood flow on laser probe temperature in human arteries

et al. 1988

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“…1,2) Hepatocellular carcinoma (HCC) is one of the most common types of cancers and is mainly caused by persistent infection of hepatitis B virus, hepatitis C virus or cirrhosis. [3][4][5][6][7] Transcatheter arterial chemo-embolization (TACE) is a catheter-based therapy and an efficacious treatment for liver tumors 8) which was introduced in the early 80 s. 5) Since polycythematous HCC is sustained by arterial blood, an emulsion of the anticancer drug and Lipiodol ® is injected into the nutrient blood vessels together with an embolic material, which results in necrosis of the tumor. TACE used with Lipiodol ® is an effective technique for HCC therapy where Lipiodol ® is essentially an iodinated oil.…”

mentioning

confidence: 99%

Measurement of temperature dependence of sound velocity in biological tissues

Tsujimoto

Matsuda

Minamiguchi

et al. 2019

Jpn. J. Appl. Phys.

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Transcatheter arterial chemo-embolization using Lipiodol ® is one of the treatments for hepatocellular carcinoma. During this procedure, it is important to monitor the Lipiodol ® deposited inside tumors. This study proposes a method for measurement of the temperature dependence of the velocity of sound in biological tissues. An ultrasonic pulse-echo method was used to measure the velocity of sound. The temperature coefficients of the velocity of sound for Lipiodol ® was −2.82 m s −1 °C−1 . Values of 1.07 and 1.59 m s −1 °C−1 were obtained for normal rat liver and cancerous liver tissue, respectively. Thus, this procedure may potentially allow for the evaluation of the infiltration of Lipiodol ® inside tumors.

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Peripheral percutaneous transluminal laser angioplasty in humans: In vitro investigations and clinical results with a novel laser catheter system

Neubaur

Klepzig²,

Heintzen³

et al. 1989

Clinical Cardiology

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Summary: Percutaneous transluminal laser angioplasty has become an accepted method of treatment of peripheral arterial occlusive disease. To minimize the risk of arterial wall perforation during laser angioplasty, a novel laser catheter system was developed. In 113 obliterated postmortem human arteries the perforation rate was 0.9%. The mean degree of stenosis was reduced from 89 i-9 % before, to 53 -f 11 % after laser irradiation. Clinical Nd:YAG laser angioplasty was performed in 19 patients suffering from peripheral arterial occlusive disease. The Fontaine stage improved in 16 patients; in no case did it deteriorate. The mean degree of stenosis was reduced by laser angioplasty from 9 1 & 12 % to 3 1 * 19 % . A further reduction down to 13 k 18 % was achieved by subsequent percutaneous transluminal balloon angioplasty . The systolic Doppler ankle-arm pressure gradient was improved from 0.58k0.26 to 0.89k0.25. In 7 patients microemholisms were detectable on the final angiogm . There was no acute reocclusion and no perforation. Within a followup period of 12 months, four restenoses were diagnosed by digital subtraction angiography. On average, the Doppler index was 0.75k0.32.

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Laser angioplasty of arterial stenoses

Cited by 13 publications

References 22 publications

Effects of blood flow on laser probe temperature in human arteries

Effects of blood flow on laser probe temperature in human arteries

Measurement of temperature dependence of sound velocity in biological tissues

Peripheral percutaneous transluminal laser angioplasty in humans: In vitro investigations and clinical results with a novel laser catheter system

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