Laser-activated nano-biomaterials for tissue repair and controlled drug release

Matteini, Paolo; Ratto, Fulvio; Rossi, Francesca; Pini, Roberto

doi:10.1070/qe2014v044n07abeh015484

Cited by 10 publications

(2 citation statements)

References 67 publications

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“…Thus, pH of surrounding tissue can be the control parameter for drug release from calcium microspheres. In Ref [24] thermosensitive micelles with laser-stimulated drug release were developed.…”

Section: Resultsmentioning

confidence: 99%

In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

Genina

Svenskaya

Yanina

et al. 2016

Biomed. Opt. Express

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Abstract:We have developed a method for delivery of biocompatible CaCO 3 microcontainers (4.0 ± 0.8 µm) containing Fe 3 O 4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 μm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.

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Section: Resultsmentioning

confidence: 99%

In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

Genina

Svenskaya

Yanina

et al. 2016

Biomed. Opt. Express

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“…As ICG is unstable in aqueous solutions and prone to fast photo-bleaching, the use of a stabilizing system, such as encapsulation in nanoparticles (NPs), increases precision and success of the procedure. Alternatively, gold NPs (Au-NPs) allow for localized and precise application of LTS [7–8].…”

Section: Introductionmentioning

confidence: 99%

Effects of gold and PCL- or PLLA-coated silica nanoparticles on brain endothelial cells and the blood–brain barrier

Bittner

Ducray

Widmer

et al. 2019

Beilstein J. Nanotechnol.

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Nanomedicine is a constantly expanding field, facilitating and improving diagnosis and treatment of diseases. As nanomaterials are foreign objects, careful evaluation of their toxicological and functional aspects prior to medical application is imperative. In this study, we aimed to determine the effects of gold and polymer-coated silica nanoparticles used in laser tissue soldering on brain endothelial cells and the blood–brain barrier using rat brain capillary endothelial cells (rBCEC4). All types of nanoparticles were taken up time-dependently by the rBCEC4 cells, albeit to a different extent, causing a time- and concentration-dependent decrease in cell viability. Nanoparticle exposure did not change cell proliferation, differentiation, nor did it induce inflammation. rBCEC4 cells showed blood–brain barrier characteristics including tight junctions. None of the nanoparticles altered the expression of tight junctions or impaired the blood–brain barrier permeability. The findings suggest that effects of these nanoparticles on the metabolic state of cells have to be further characterized before use for medical purposes.

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Prediction of Tensile Strength of Biotissue Laser Welds by Machine Learning Methods

2023

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Laser-activated nano-biomaterials for tissue repair and controlled drug release

Cited by 10 publications

References 67 publications

In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

Effects of gold and PCL- or PLLA-coated silica nanoparticles on brain endothelial cells and the blood–brain barrier

Prediction of Tensile Strength of Biotissue Laser Welds by Machine Learning Methods

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