Laser ablation-ICP-mass spectrometry for determination of the concentrations and spatial distributions of bromine and iodine in human hair

Abstract

Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) was applied for the determination of Br and I in hair strands of human individuals under treatment with synthetic thyroid hormones. Quantification relied on...

Quantification anomalies in single pulse LA-ICP-MS analysis associated with laser fluence and beam size

“…However, matrix-matched standards are hardly ever available, especially for biological samples, hence a number of calibration strategies have emerged, 8 such as homogenization of tissue and standard addition of element(s) of interest, 9 spiking of the samples by soaking in solution (e.g. for hair samples), 10 preparation of external standards in gelatin that mimic the tissue matrix, 11,12 including microdroplet standards, 13 (in-cell or in-torch) aspiration of a standard solution during laser sampling, [14][15][16] and application of a "film" standard on/under a biological sample combined with total consumption (i.e. ablation of the entire depth) of the assembly.…”

New Analytical Strategy for Bioaccessibility Evaluation of Bromine and Iodine from Edible Seaweeds

“…However, a provisional acceptable daily intake for bromine is 0.4 mg kg –1 of body weight; considering studies with human volunteers, no adverse effects were observed at levels of 4 mg kg –1 of body weight . Determination of bromine and iodine concentrations in seaweeds can help in the context of environmental and health issues. , …”

“…The European Commission by Scientific Committee of Food established the upper intake level for iodine equal to 600 μg day −1 for adults. 44 Bromine is not an essential trace element, and the scientific literature has not established its requirements. However, a provisional acceptable daily intake for bromine is 0.4 mg kg −1 of body weight; considering studies with human volunteers, no adverse effects were observed at levels of 4 mg kg −1 of body weight.…”

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

“…The use of matrix matched calibrators to improve accuracy of LA-ICP-MS measurements in solid materials was the focus of two papers over the review period. Novo et al 80 reported a well-conducted study in which in-house Br and I-spiked hair strands were used as calibrators to determine concentrations and spatial distributions of these halogens in human hair. Highly linear calibration curves were obtained and longitudinal and cross-sectional scanning studies proved that the calibration material was adequately homogeneous.…”

“…Novo et al 80 published an investigation into the quantification and distribution of Br and I in hair . Matrix-matched calibration standards were prepared using hair strands soaked in various concentrations of Br and I for 24 h, before rinsing and drying.…”