Lasalocid Toxicosis in Dairy Calves

Lasalocid Toxicosis in Neonatal Calves

“…4,6 In an experimental study, single doses of 10 mg/kg had no effect, whereas doses of 50 mg/kg or higher resulted in tachycardia, muscle tremors, diarrhea, and death in 5 of 6 animals treated. 5 Gross lesions were pleural effusion, myocardial petechiae, and cardiac dilatation.…”

“…Toxicosis associated with a feed mixing error also has been reported; in that case, feed samples contained 1,010-1,700 ppm lasalocid, 50 times the recommended concentration of 33 ppm, which would have been expected to deliver the recommended dosage of 1 mg/kg/day. 4 Lesions at necropsy were myocardial hemorrhage and pleural effusion. The most consistently reported histopathologic change in intoxicated feeder calves has been myocardial necrosis.…”

“…The most consistently reported histopathologic change in intoxicated feeder calves has been myocardial necrosis. 4,6,14 Rumen and skeletal muscle lesions were not reported.…”

“…Lasalocid is an ionophore used as a growth promotant feed additive in cattle and as a coccidiostat in cattle, sheep, and poultry. 1,10 Lasalocid toxicosis has been reported in feeder calves following feed mixing errors 4 and in neonatal calves after administration of lasalocid. 9 In the absence of an approved treatment for cryptosporidiosis in neonatal calves, the off-label use of lasalocid for this purpose has been attempted in the field using several dosage forms.…”

Intoxicação espontânea por antibióticos ionóforos em ovinos no Rio Grande do Sul

“…Casos de intoxicação por AI usualmente são resultado da suplementação com ração ou outro tipo de alimento contendo AI (Nation et al 1982, Newsholme et al 1983, Blanchard et al 1993, Gava et al 1997, Jones 2001, Dedoussi et al 2007), da ingestão acidental de rações contendo esses compostos por espécies não-alvo (Perelman et al 1993, Baird et al 1997, Shlosberg et al 1997, Segev et al 2004) ou em situações onde há o envolvimento de substâncias que potencializam a ação dos AI, retardando a eliminação pelo organismo ). Nos casos deste surto, os ovinos tiveram acesso a um aditivo alimentar para frangos contendo 250g/kg de narasina.…”