Larynx-sparing techniques using intensity-modulated radiation therapy for oropharyngeal cancer

Ad, Voichita Bar; Lin, Haibo; Hwang, Wei–Ting; Deville, Curtiland; Dutta, Pinaki; Tochner, Zelig; Both, Stefan

doi:10.1016/j.meddos.2012.02.004

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…These structures may be impacted during radiotherapy for oropharyngeal cancers. Therefore, an advanced radiation technique that reduces the radiation dose to the SRSs could help mitigate swallowing problems [ 1 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Sparing Swallowing-Related Structures Reduces Post-Radiotherapy Dysphagia in Oropharyngeal Cancer

Wasuthalainun,

Keskool,

Petsuksiri

et al. 2024

Asian Pac J Cancer Prev

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Objective: To identify swallowing-related structures (SRSs) predicting post-radiotherapy dysphagia in oropharyngeal carcinoma patients. Material and methods: Between September 2020 and October 2022, oropharyngeal cancer patients who had completed radiotherapy at least one year before without recurrence or residuals were selected. They underwent flexible endoscopic evaluation of swallowing (FEES) assessments and dysphagia grading. The mean radiation doses delivered to their SRSs were recalculated. The correlation between radiation doses to each SRS and FEES scores was analysed. Results: Twenty-nine participants, aged 51–73 years, were enrolled. Six patients had received two-dimensional radiotherapy, eight had undergone three-dimensional conformal radiotherapy, and fifteen had received intensity-modulated radiation therapy. Radiation doses to the inferior pharyngeal constrictor, cricopharyngeus and glottic larynx significantly predicted dysphagia for both semisolids (p = 0.023, 0.030 and 0.001) and liquid diets (p = 0.021, 0.013 and 0.002). The esophageal inlet significantly predicted swallowing outcomes for only the liquid diet (p = 0.007). Conclusions: This study supports that SRS-sparing during radiotherapy for oropharyngeal cancers improves swallowing outcomes.

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Section: Introductionmentioning

confidence: 99%

Sparing Swallowing-Related Structures Reduces Post-Radiotherapy Dysphagia in Oropharyngeal Cancer

Wasuthalainun,

Keskool,

Petsuksiri

et al. 2024

Asian Pac J Cancer Prev

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“…Therefore, reduction in irradiated volume and dose to local organs may lower the risk and severity of radiation induced complications [2]. Advanced conventional delivery techniques such as intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) have improved the outlook for OAR for HN patients in the past several decades [3]. Proton therapy has the potential to further improve OAR sparing and reduce integral dose resulting from the intrinsic physics of the proton beam [4].…”

Section: Introductionmentioning

confidence: 99%

Robustness Evaluation of a Novel Proton Beam Geometry for Head and Neck Patients Treated with Pencil Beam Scanning Therapy

Huang¹,

Liu²,

Shen³

et al. 2018

IJMPCERO

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Background: To evaluate the robustness of head and neck treatment using proton pencil beam scanning (PBS) technique with respect to range uncertainty (RU) and setup errors (SE), and to establish a robust PBS planning strategy for future treatment. Methods and Materials: Ten consecutive patients were planned with a novel proton field geometry (combination of two posterior oblique fields and one anterior field with gradient dose match) using single-field uniform dose (SFUD) planning technique and the proton plans were dosimetrically compared to two coplanar arc VMAT plans. Robustness of the plans, with respect to range uncertainties (RU = ± 3% for proton) and setup errors (SE = 2.25 mm for proton and VMAT), in terms of deviations to target coverage (CTV D98%) and OAR doses (max/mean), were evaluated and compared for each patient under worst case scenarios. Results: Dosimetrically, PBS plans provided better sparing to larynx (p = 0.005), oral cavity (p < 0.001) and contralateral parotid (p = 0.004) when compared to VMAT. CTV D98% variations were higher from SE than from RU for proton plans (−1.1% ± 1.3 % vs −0.4% ± 0.7% for nodal CTV and −1.4% ± 1.2 vs −0.4% ± 0.5% % for boost CTV). Overall, the magnitudes of variation of CTV D98% to combined SE and RU were found to be similar to the impact of the SE on the VMAT plans (−1.6% ± 1.9% vs −1.7% ± 1.4% for nodal CTV and −1.9% ± 1.6% vs −1.3% ± 1.5% for boost CTV). Compared to VMAT, a larger range of relative dose deviations were found for OARs in proton plans, but safe doses were maintained for cord (41.8 ± 3.6 Gy for PBS and 41.7 ± 3.9 Gy for VMAT) and brainstem (35.2 ± 8.4 Gy for PBS and 36.2 ± 5.

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Patient-Reported Voice and Speech Outcomes After Whole-Neck Intensity Modulated Radiation Therapy and Chemotherapy for Oropharyngeal Cancer: Prospective Longitudinal Study

Vainshtein

Griffith

Feng

et al. 2014

International Journal of Radiation Oncology*Biology*Physics

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Larynx-sparing techniques using intensity-modulated radiation therapy for oropharyngeal cancer

Cited by 3 publications

References 17 publications

Sparing Swallowing-Related Structures Reduces Post-Radiotherapy Dysphagia in Oropharyngeal Cancer

Sparing Swallowing-Related Structures Reduces Post-Radiotherapy Dysphagia in Oropharyngeal Cancer

Robustness Evaluation of a Novel Proton Beam Geometry for Head and Neck Patients Treated with Pencil Beam Scanning Therapy

Patient-Reported Voice and Speech Outcomes After Whole-Neck Intensity Modulated Radiation Therapy and Chemotherapy for Oropharyngeal Cancer: Prospective Longitudinal Study

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