Larynx and Hypopharynx Cancer

Garden, Adam S.; Beadle, Beth M.; Morrison, William H.

doi:10.1016/b978-0-323-24098-7.00035-6

Cited by 6 publications

(10 citation statements)

References 191 publications

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“…Hypopharyngeal cancer has the highest mortality rate among all the head and neck carcinoma types. The latter cancer has one of the worst prognoses of any malignant head and neck cancer, and the 5-year survival rate is ~15–65% (Edwards and Mendes, 2011; Krstevska et al, 2012; Garden et al, 2016). The 5-year survival rate for early-stage (T1–T2) patients is ~60%, while an overall survival rate of only 17–32% is observed for late-stage patients (Zeng et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Variations in Oral Microbiota Composition Are Associated With a Risk of Throat Cancer

Wang¹,

Yin

Guo³

et al. 2019

Front. Cell. Infect. Microbiol.

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In this study, a next-generation sequencing strategy on 16 S ribosomal RNA (16 S rRNA) gene was employed to analyze 70 oral samples from 32 patients with throat cancer, nine patients with vocal cord polyp, and 29 healthy individuals (normal controls). Using this strategy, we demonstrated, for the first time, that the salivary microbiota of cancer patients were significantly different from those of patients with a polyp and healthy individuals. We observed that the beta diversity of the cancer group was divergent from both the normal and polyp groups, while alpha-diversity indices such as the Chao1 estimator ( P = 8.1e-05), Simpson ( P = 0.0045), and Shannon ( P = 0.0071) were significantly reduced in cancer patients compared with patients containing a polyp and normal healthy individuals. Linear discriminant analysis (LDA) and Kruskal–Wallis test analyses and real-time quantitative polymerase chain reaction (qPCR) verification test revealed that the genera Aggregatibacter, Pseudomonas, Bacteroides , and Ruminiclostridium were significantly enriched in the throat cancer group compared with the vocal cord polyp and normal control groups (score value >2). Finally, diagnostic models based on putatively important constituent bacteria were constructed with 87.5% accuracy [area under the curve (AUC) = 0.875, 95% confidence interval (CI): 0.695–1]. In summary, in this study we characterized, for the first time, the oral microbiota of throat cancer patients without smoking history. We speculate that these results will help in the pathogenic mechanism and early diagnosis of throat cancer.

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Section: Introductionmentioning

confidence: 99%

Variations in Oral Microbiota Composition Are Associated With a Risk of Throat Cancer

Wang¹,

Yin

Guo³

et al. 2019

Front. Cell. Infect. Microbiol.

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“…13,14 In 1974, Bataini and colleagues published an overall loco regional control rate of 76% for relatively large series patients with T1, T2, N0-2 supraglottic carcinomas treated by radiotherapy alone. 9 In our study, 1 year larynx preservation rate in stage II is 78%. Locally advanced laryngeal cancers (stages III and IV) require radical surgery followed by external radiotherapy.…”

Section: Discussionmentioning

confidence: 45%

“…Usually the laryngeal cancer patients median age of presentation is 65 years and less than 4% of our patients are younger than 45 years old and it is seen predominantly in male population. 9 Approximately two thirds of patients with laryngeal cancer have their disease limited to the laryngeal structures and less than 10% present with distant metastases at presentation. 9 In our study, median age of presentation is 58 years and 76% of patients were males.…”

Section: Discussionmentioning

confidence: 99%

“…9 Approximately two thirds of patients with laryngeal cancer have their disease limited to the laryngeal structures and less than 10% present with distant metastases at presentation. 9 In our study, median age of presentation is 58 years and 76% of patients were males. Majority of laryngeal cancer patients are now treated with organ preservation protocols.…”

Section: Discussionmentioning

confidence: 99%

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Retrospective Analysis of Rate of Larynx Preservation in Locally Advanced Laryngopharyngeal Squamous Cell Carcinoma Following Chemo RT – An Institution Based Study

Madhumathi¹

2019

jmscr

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Introduction: Chemo-radiation preceded by induction chemotherapy is reported valuable alternative to laryngectomy in laryngeal cancer for larynx preservation. This study was performed to assess the influence chemo radiation on preservation of larynx. Materials and Methods: Sixty-three patients treated from January 2013 to December 2014 in our institute were reviewed and who were available for follow-up in this retrospective study. Total dose of 66-70 Gray was used at 2 gray per fraction daily for five days week were used. Larynx preservation rate at 1 year of median follow-up were analysed. Results: Among 63 patients, larynx preservation was possible in 50 patients (78%). With chemoradiation, excellent preservation of larynx was achieved in stage II (78%) disease, while in advanced stage III and stage IVA, larynx preservation was67.06% and 64.35%, respectively. Conclusion: Chemo-radiation (either neoadjuvant chemotherapy followed by chemoradiation or concurrent chemo-radiation) has better larynx preservation rate in early as well was advanced laryngeal cancer patients.

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“…4 Other causes that have been implicated in it's aetiology are alcohol consumption, occupational exposure to certain carcinogens, radiation exposure and genetic factors. 5 Malignant tumors of the larynx may affect laryngeal physiology depending on tumor location and size leading to various clinical presentations. 6 The main treatments for laryngeal malignancy are radiotherapy, surgery and chemotherapy depending on the stage of the disease.…”

Section: Introductionmentioning

confidence: 99%

Laryngeal malignancy: epidemiology and staging at the time of presentation in a rural population

Shariff

2018

Int J Otorhinolaryngol Head Neck Surg

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Background: Laryngeal cancer is one of the 10 leading causes of cancer in Indian men. Late presentation of the disease may worsen management outcomes. Consumption of tobacco and alcohol is associated with the development of laryngeal malignancy.Methods: A cross-sectional study was conducted in the Department of ENT, at Chamarajanagar Institute of Medical Sciences and Hospital, Chamarajanagar, India, for a period of 2 years 6 months from October 2014 to March 2017. During the study period, all cases that were diagnosed as Laryngeal malignancy by histopathology were included in the study group. The aim of this study is to determine the epidemiology, anatomical location of the tumor at presentation, clinical presentation and the stage of the tumor at the time of presentation. Results: Majority of patients were elderly male from lower socio-economic strata. The most common clinical presentations were change in voice, pain in throat, difficulty in swallowing, lump in neck and difficulty in breathing. Supraglottis (82%) was the most common anatomic location of tumor. 60% of the patients presented in stage III of the disease. All the cases were squamous cell carcinoma.Conclusions: Laryngeal malignancy is a relatively uncommon malignancy in general population but is more common in rural population especially in people belonging to lower socio-economic strata. Supraglottic malignancy is the most common anatomic location of laryngeal malignancy. Majority of the cases from rural population presented in an advanced stage of the disease.

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Larynx and Hypopharynx Cancer

Cited by 6 publications

References 191 publications

Variations in Oral Microbiota Composition Are Associated With a Risk of Throat Cancer

Variations in Oral Microbiota Composition Are Associated With a Risk of Throat Cancer

Retrospective Analysis of Rate of Larynx Preservation in Locally Advanced Laryngopharyngeal Squamous Cell Carcinoma Following Chemo RT – An Institution Based Study

Laryngeal malignancy: epidemiology and staging at the time of presentation in a rural population

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