Retrospective Analysis of Rate of Larynx Preservation in Locally Advanced Laryngopharyngeal Squamous Cell Carcinoma Following Chemo RT – An Institution Based Study

Abstract

Introduction: Chemo-radiation preceded by induction chemotherapy is reported valuable alternative to laryngectomy in laryngeal cancer for larynx preservation. This study was performed to assess the influence chemo radiation on preservation of larynx. Materials and Methods: Sixty-three patients treated from January 2013 to December 2014 in our institute were reviewed and who were available for follow-up in this retrospective study. Total dose of 66-70 Gray was used at 2 gray per fraction daily for five days week were used. Larynx preservation rate at 1 year of median follow-up were analysed. Results: Among 63 patients, larynx preservation was possible in 50 patients (78%). With chemoradiation, excellent preservation of larynx was achieved in stage II (78%) disease, while in advanced stage III and stage IVA, larynx preservation was67.06% and 64.35%, respectively. Conclusion: Chemo-radiation (either neoadjuvant chemotherapy followed by chemoradiation or concurrent chemo-radiation) has better larynx preservation rate in early as well was advanced laryngeal cancer patients.