Laryngotracheal Reconstruction for Subglottic and Tracheal Stenosis

Perryman, Mollie; Kraft, Shannon; Kavookjian, Hannah

doi:10.1016/j.otc.2023.04.018

Cited by 3 publications

(4 citation statements)

References 56 publications

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“…causes, such as diphtheria and syphilis, to iatrogenic causes, namely prolonged intubation and tracheostomy [28]. Injury to the trachea can significantly decrease an individual's quality of life by impacting breathing, speaking, and swallowing.…”

Section: Tracheamentioning

confidence: 99%

“…The turn of the 20th century saw a leap in medical innovation and critical care medicine. The development of endotracheal intubation and mechanical ventilation led to the prolongation of life, but also shifted the etiology of tracheal stenosis away from infectious causes, such as diphtheria and syphilis, to iatrogenic causes, namely prolonged intubation and tracheostomy [ 28 ]. Injury to the trachea can significantly decrease an individual’s quality of life by impacting breathing, speaking, and swallowing.…”

Section: Tracheamentioning

confidence: 99%

“…Tracheal resection also carries significant morbidity and complications can be disastrous. Patients who cannot be addressed with tracheal resection are managed with endoscopic laser excision, balloon dilation, and stenting, which are suboptimal and require repeat surgeries [ 28 , 29 , 30 ]. Figure 1 demonstrates endoscopic intraluminal views of an airway with tracheal stenosis prior to and immediately after endoscopic rigid dilation with silicone stenting [ 31 ].…”

Section: Tracheamentioning

confidence: 99%

“…The trachea has two primary functions: to be a ventilatory circuit from the upper airway to the lungs and to clear tracheobronchial secretions. The trachea is composed of an internal lining of ciliated respiratory epithelium and an external framework composed of hyaline cartilage that is not only flexible enough to support the bending and twisting of the neck but is also rigid enough to withstand dynamic collapse during inspiration and high positive pressures during forceful expiration [ 4 , 28 ]. The trachea is unique in that the anterior two-thirds is composed of 18–22 C-shaped cartilaginous rings approximately 4 mm in length, with an intercartilaginous membrane between rings, as shown in Figure 2 .…”

Section: Tracheamentioning

confidence: 99%

See 3 more Smart Citations

A Contemporary Review of Trachea, Nose, and Ear Cartilage Bioengineering and Additive Manufacturing

Feng,

Ahmed,

Punjabi

et al. 2024

Biomimetics

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The complex structure, chemical composition, and biomechanical properties of craniofacial cartilaginous structures make them challenging to reconstruct. Autologous grafts have limited tissue availability and can cause significant donor-site morbidity, homologous grafts often require immunosuppression, and alloplastic grafts may have high rates of infection or displacement. Furthermore, all these grafting techniques require a high level of surgical skill to ensure that the reconstruction matches the original structure. Current research indicates that additive manufacturing shows promise in overcoming these limitations. Autologous stem cells have been developed into cartilage when exposed to the appropriate growth factors and culture conditions, such as mechanical stress and oxygen deprivation. Additive manufacturing allows for increased precision when engineering scaffolds for stem cell cultures. Fine control over the porosity and structure of a material ensures adequate cell adhesion and fit between the graft and the defect. Several recent tissue engineering studies have focused on the trachea, nose, and ear, as these structures are often damaged by congenital conditions, trauma, and malignancy. This article reviews the limitations of current reconstructive techniques and the new developments in additive manufacturing for tracheal, nasal, and auricular cartilages.

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Section: Tracheamentioning

confidence: 99%

Section: Tracheamentioning

confidence: 99%