Laryngeal Squamous Cell Carcinomas are Commonly Associated With Differentiated Squamous Intraepithelial Neoplasia With or Without an Admixture With Usual Type of Squamous Intraepithelial Neoplasia: Clinical and Pathologic Significance

Kien, T.; Hogan, Kevin T.; Wasserman, Jason K.

doi:10.1097/pai.0000000000000425

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…It should be noted that the nomenclature used to describe the cytomorphological subtypes of dysplasia in this study has long been used (except for the spindle cell type) to describe similar lesions in the skin or squamous epithelial mucosa. For example, the term differentiated subtype is used for dysplasia of the oral cavity, 31,32 pharynx, 32,33 anal canal, 34,35 and vulva (non-HPV-related). 36,37 Arsenic and Kurrer 32 classified dysplasia of the oropharynx into basaloid, pleomorphic, mixed, differentiated, and verrucous subtypes, among which, the differentiated subtype was the most common.…”

Section: Discussionmentioning

confidence: 99%

Morphological Characteristics of Various Cells in Esophageal Squamous Dysplasia: Extremely Wide Morphological Spectrum

Hou,

Song,

Duan

et al. 2023

Int J Surg Pathol

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The WHO classification of esophageal tumors divides esophageal squamous intraepithelial dysplasia into high and low grades, but does not specify its morphological spectrum. Here, the morphological characteristics of various cells were investigated in esophageal squamous (high-grade) dysplasia, and a morphological spectrum and terminology for this lesion were proposed to avoid misdiagnosis. The clinicopathological data of 540 patients with esophageal squamous dysplasia were analyzed retrospectively. According to the unique cytomorphological characteristics of the lesions and the predominant cell type, the esophageal squamous dysplasia was divided into the following morphological groups: classic type (34.6%, 187/540), basaloid subtype (10.7%, 58/540), spindle-cell subtype (4.6%, 25/540), differentiated subtype (48.9%, 264/540), and verrucous subtype (1.1%, 6/540). Gender, age, and lesions location did not differ among the subtypes ( P > 0.05), while Paris classification and lesions diameter significantly differed among the subtypes ( P < 0.01). Classic-type cells showed severe atypia. In the basaloid subtype, the cells were small, and resembled basal cells; most of these lesions were of the 0-IIb type with small lesion diameter. In the spindle-cell subtype, the cells and nuclei were spindle-shaped or long and spindle-shaped and arranged in parallel. Differentiated-subtype showed well-to-moderately differentiated cells, and epithelial basal cells were mature. Verrucous-subtype showed well-differentiated cells, and were characterized by verrucous or papillary structures. Esophageal squamous dysplasia has extremely wide morphological spectrum. Awareness of the spectrum of morphological presentations of this lesion, specifically the basaloid subtype, spindle-cell subtype, differentiated subtype, and verrucous subtype, is important for accurate diagnosis.

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Section: Discussionmentioning

confidence: 99%

Morphological Characteristics of Various Cells in Esophageal Squamous Dysplasia: Extremely Wide Morphological Spectrum

Hou,

Song,

Duan

et al. 2023

Int J Surg Pathol

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Laryngeal Dysplasia: Persisting Dilemmas, Disagreements and Unsolved Problems—A Short Review

Gale

Cardesa

Hernández-Prera

et al. 2020

Head and Neck Pathol

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Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile

Koopmansch¹,

Maris²,

Demetter

et al. 2019

Case Reports in Pathology

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Differentiated-type Intraepithelial Neoplasia (DIN) is defined as HPV-negative squamous intraepithelial proliferation with abnormal keratinocyte differentiation and basal cell atypia, originally described in the vulva, with following descriptions in the oral cavity. DIN occurring in the anus is quite rare, and to the best of our knowledge, only one publication reported it. In this report, we describe the clinicopathological features of this entity on anal margin, associated with invasive squamous cell carcinoma. In addition, using the next generation sequencing (NGS) technique, we have demonstrated TP53 mutation in the invasive component but not in the associated DIN-like lesion, where p53 immunohistochemical expression was restricted to basal layers.

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Laryngeal Squamous Cell Carcinomas are Commonly Associated With Differentiated Squamous Intraepithelial Neoplasia With or Without an Admixture With Usual Type of Squamous Intraepithelial Neoplasia: Clinical and Pathologic Significance

Cited by 3 publications

References 28 publications

Morphological Characteristics of Various Cells in Esophageal Squamous Dysplasia: Extremely Wide Morphological Spectrum

Morphological Characteristics of Various Cells in Esophageal Squamous Dysplasia: Extremely Wide Morphological Spectrum

Laryngeal Dysplasia: Persisting Dilemmas, Disagreements and Unsolved Problems—A Short Review

Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile

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