Laryngeal osteosarcoma: A clinicopathologic analysis of four cases and comparison with a carcinosarcoma

Madrigal, Fernando Martinez; Godoy, Luz María Ruiz; Daboin, Keyla Pineda; Casiraghi, Odile; García, Abelardo Meneses; Luna, Mario A.

doi:10.1053/adpa.2002.30604

Cited by 19 publications

(11 citation statements)

References 12 publications

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“…Osteosarcoma of the larynx is extremely rare and demonstrates many differences from osteosarcoma of other head and neck sites. Only 24 cases of laryngeal osteosarcoma were reported from 1942 to 2009 (Table ), excluding 2 patients who were not described in detail and were lost to follow‐up shortly after surgery. Among these 24 cases, the median age at diagnosis was 64 years (range, 47–80 years), and most patients were men (92%).…”

Section: Discussionmentioning

confidence: 99%

Laryngeal osteosarcoma: Case report and literature review

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Laryngeal osteosarcoma: Case report and literature review

et al. 2014

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“…The majority of them occur in males between the sixth and eighth decades of life. LOS has been associated with previous radiotherapy in two cases 4 13. Patients usually present with non-specific symptoms such as dysphonia and upper airway compromise.…”

Section: Discussionmentioning

confidence: 99%

Extraskeletal osteosarcoma of the larynx: an extremely unusual tumour

et al. 2014

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Osteosarcoma of the larynx is probably the rarest mesenchymal tumour of the larynx, with only 16 cases reported so far. The majority of them occur in males between the sixth and eighth decades of life. Patients usually present with non-specific symptoms such as dysphonia and upper airway compromise. The most common site of distant metastasis is the lung. Clinically, the tumour follows an aggressive course and is associated with high mortality. The case we present is unusual as it occurred at a young age (38 years) as compared with the norm and it did not arise from the endolarynx, unlike many of the other cases. This was the only known case where a Pearson near-total laryngectomy was performed whereby the patient's natural speech mechanism was preserved. This surgery was possible because the contralateral half of the larynx was clearly disease free and the interarytenoid region was uninvolved. The patient underwent postoperative adjuvant external beam radiotherapy beginning 4 weeks after surgery. The patient is doing well after 15 months of follow-up and shows no signs of recurrence.

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“…High-grade chondrosarcomas are characterized by increased cellularity, by more atypical features, such as plump binucleated Á/multinucleated cells, and by frequent mitoses. Osteosarcoma is the rarest of the laryngeal sarcomas and, to the best of our knowledge, only 24 laryngeal osteosarcomas have been reported, including 4 in a recent report by Martinez Madrigal et al (8). Osteosarcomas are composed of (i) sarcomatous spindle-shaped cells with atypical nuclei and frequent mitoses; (ii) osteoid deposits and immature bony trabeculae outlined by giant osteoclastic-type cells and tumour osteoblastic cells; and (iii) chondroid zones.…”

Section: Discussionmentioning

confidence: 99%

“…Spindle cell tumours of the larynx are quite uncommon, accounting for 1.3% of tumours at this site (6), but they frequently present different types of stromal metaplasia and may exhibit osteoid, chondroid, rhabdomyoblastic or giant cell metaplastic changes (7,8). Obviously, immunohistochemical reactions are extensively used to define the nature of proliferative spindle cells, but approximately one-third of these laryngeal tumours are negative for cytokeratins, probably owing to the loss of identifiable specific markers (9).…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of the larynx with osteosarcoma-like stromal metaplasia

Marioni

Altavilla

Marino

et al. 2004

Acta Oto-Laryngologica

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Osseous or chondroid metaplasias are uncommonly found adjacent to laryngeal squamous cell carcinoma (SCC). These findings are less unusual in the spindle cell variant. We describe a moderately differentiated laryngeal SCC associated with osteocartilaginous metaplasia of the adjacent stroma which exhibited very similar morphologic changes and mitoses to an osteosarcoma. These uncommon findings can be more clearly understood if they are viewed as changes determined by the microenvironment of the tumour-host interface, as indicated in recent studies. Tumour cells seem able to regulate stromal development and differentiation via the release of growth factors and the induction of growth factor receptor expression on the cell surface. Irrespective of the limited number of reported cases, the association of SCCs of the larynx with osteocartilaginous metaplasia does not seem to support the adoption of treatments of choice that differ in approach to those for site- and stage-matched SCCs without osteocartilaginous metaplasia.

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Laryngeal osteosarcoma: A clinicopathologic analysis of four cases and comparison with a carcinosarcoma

Cited by 19 publications

References 12 publications

Laryngeal osteosarcoma: Case report and literature review

Laryngeal osteosarcoma: Case report and literature review

Extraskeletal osteosarcoma of the larynx: an extremely unusual tumour

Squamous cell carcinoma of the larynx with osteosarcoma-like stromal metaplasia

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