Laryngeal Manifestations of Gout

Guttenplan, Michael D.; Townsend, Mary; Hendrix, Robert A.; Balsara, Gulnar

doi:10.1177/000348949110001108

Cited by 36 publications

(21 citation statements)

References 10 publications

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“…Artrite gotosa laríngea com rouquidão, disfonia e disfagia pode acompanhar o envolvimento de múltiplas articulações ou aparecer como uma manifestação isolada da gota. Tofo em laringe ou corda vocal causando sintomas similares raramente tem sido descrito (36) . Ulceração degenerativa na articulação cricoaritenóide lembrando osteoartrite (OA) também pode ocorrer.…”

Section: Injúrias Oral Faríngea E Laríngeaunclassified

Manifestações otorrinolaringológicas nas doenças reumáticas auto-imunes

Pereira¹,

Amaral²,

Szajubok³

et al. 2006

Rev. Bras. Reumatol.

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RESUMOAs manifestações otorrinolaringológicas nas doenças reumáticas representam um desafio diagnóstico para o reumatologista, o otorrinolaringologista e o médico generalista. Comumente, sintomas otorrinolaringológicos representam um sinal inicial de uma doença assintomática ou uma desordem auto-imune não diagnosticada, que freqüentemente exige um imediato e agressivo tratamento imunossupressor. Distúrbios auditivos podem ser vistos em pacientes com lúpus eritematoso sistêmico (LES), granulomatose de Wegener (GW), policondrite recidivante (PR), poliarterite nodosa, síndrome de Cogan, síndrome de Sjögren e menos freqüentemente na síndrome de Churg-Strauss e doença de Behçet. O nariz e seios paranasais são variavelmente afetados durante o curso da GW, síndrome de Churg-Strauss, PR e sarcoidose. Ulcerações mucosas recorrentes são comuns no LES e doença de Behçet. Xerostomia é uma manifestação comum da síndrome de Sjögren primária e secundária; aumento da glândula salivar pode ser visto nesses pacientes, assim como nos pacientes com sarcoidose. A articulação cricoaritenóide pode ser envolvida durante o curso da artrite reumatóide, espondilite anquilosante e gota; alterações osteoartríticas também têm sido descritas. Disfunção do nervo trigeminal pode ocorrer em pacientes com síndrome de Sjögren, esclerose sistêmica, LES e doença mista do tecido conjuntivo. Paralisia facial periférica tem sido descrita como complicação do curso da síndrome de Sjögren e sarcoidose.Palavras-chave: distúrbios auto-imunes, perda auditiva, sinusite, rouquidão, úlceras orais.

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Section: Injúrias Oral Faríngea E Laríngeaunclassified

Manifestações otorrinolaringológicas nas doenças reumáticas auto-imunes

Pereira¹,

Amaral²,

Szajubok³

et al. 2006

Rev. Bras. Reumatol.

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“…Neutrophils ingest the crystals and initiate an inflammatory reaction, causing recurrent intermittent attacks of gouty arthritis; followed by the development of tophaceous gout as a result of a longterm failure to control high urate levels. 1 Gout has a prevalence of 9.5 per 1000 women and 16.4 per 1000 men in England. 2 Reported risk factors include age, alcohol consumption, hypertension, renal impairment, obesity, diuretics and a positive family history.…”

Section: Introductionmentioning

confidence: 99%

“…However, there have been diverse manifestations described in the head and neck region 4 including involvement of the cricoarytenoid, sternoclavicular and temporomandibular joints. 1 Tophaceous gout commonly affects the outer helix of the pinna, 5 but has also been reported as affecting the arytenoid cartilages, 6 thyroid cartilage, 7 vocal folds, 8,9 hyoid bone 10 and tongue. 11 The diagnosis of gout is made by the identification of monosodium urate crystals in either synovial fluid or in a tissue specimen.…”

Section: Introductionmentioning

confidence: 99%

Tophaceous gout presenting as a dorsal nasal lump

2005

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A literature review reveals that gout has been described as affecting many sites in the head and neck region, both in the arthritic and tophaceous form. Gout can often mimic malignancy or infection, and has been described as causing acute airway problems requiring emergency tracheotomy. Here we describe the first published case of tophaceous gout affecting the soft tissues overlying the nasal bones. The patient presented with a bony, hard, dorsal hump and requested aesthetic rhinoplasty. We also describe an endoscopic technique for removal of tophi using a powered microdebrider system with a protected burr head. Endoscopic powered microdebrider blade excision of tophi affecting the limbs has already been described, with reduced complications when compared with conventional curettage and debridement techniques. This is the first such application to the nose.

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“…The transition to chronic gout is marked by the development of visible chalky white MSU deposits known as tophi in joints of hands or feet and not uncommonly on the helix of the ear, olecranon bursa or Achilles tendon . Rarer sites of urate crystal deposits include the breast, vocal cords, heart and colon . Nephropathy and renal uric nephrolithiasis may be associated with progression of gout.…”

Section: Introductionmentioning

confidence: 99%

Review of the ophthalmic manifestations of gout and uric acid crystal deposition

Goldblatt

Casson

2016

Clinical Exper Ophthalmology

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Gout is a clinical disorder that is characterized by the deposition of monosodium urate crystals (MSU) in joints and tendons, usually in the presence of prolonged hyperuricaemia. Following an asymptomatic phase of hyperuricaemia, gout usually presents as acute monoarthritis followed by periods of remission and exacerbation. Conjunctival hyperaemia and subconjunctival haemorrhage exacerbated by purine intake are two of the more common manifestations that may go unrecognized. Other ocular and adnexal structures can be affected by urate crystal deposition and associated inflammation, with potentially vision-threatening consequences; however, ocular manifestations of gout are rare and may have been over-reported in the older literature, but our understanding of the clinic-pathological features of ocular urate deposits remains limited.

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Laryngeal Manifestations of Gout

Cited by 36 publications

References 10 publications

Manifestações otorrinolaringológicas nas doenças reumáticas auto-imunes

Manifestações otorrinolaringológicas nas doenças reumáticas auto-imunes

Tophaceous gout presenting as a dorsal nasal lump

Review of the ophthalmic manifestations of gout and uric acid crystal deposition

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