Laryngeal histoplasmosis: masquerading malignancy

Gupta, Devendra K.; Tanwar, Deepika; Patel, Bhaumik; Singh, Vikram

doi:10.1136/bcr-2022-248738

BMJ Case Rep

2022

DOI: 10.1136/bcr-2022-248738

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Laryngeal histoplasmosis: masquerading malignancy

Devendra K. Gupta

Deepika Tanwar

Bhaumik Patel

et al.

Abstract: Laryngeal histoplasmosis is a very rare cause of laryngitis which is encountered usually in the immunosuppressed states but can also occur in immunologically intact status. We report a rare case of laryngeal histoplasmosis in a man in his 60s, a chronic smoker who presented with a history of progressive hoarseness for 3 months. The glottic growth was biopsied. The rarity of diagnosis was aided by histopathological examination of the tissue, which revealed histoplasmosis. Management was done with intravenous li… Show more

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Cited by 3 publications

References 24 publications

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Histoplasmosis misdiagnosed as malignancies in immunocompetent and immunocompromised patients: A global perspective on clinical presentation, radiological and pathological findings

Benjamin,

Bassey,

Nwagboso

et al. 2024

hLife

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Histoplasmosis misdiagnosed as malignancies in immunocompetent and immunocompromised patients: A global perspective on clinical presentation, radiological and pathological findings

Benjamin,

Bassey,

Nwagboso

et al. 2024

hLife

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Histopathology of a polyploid laryngeal growth revealing disseminated histoplasmosis

Kumar,

Singh,

Agarwal

et al. 2024

AIAO

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Any polyploid growth in the laryngeal region may be mistaken for a malignant condition. Histoplasmosis of the larynx rarely causes laryngitis; it often masquerades as malignancy or tuberculosis. The other name of this condition is “Cave’s disease” and is caused by the fungus, Histoplasma capsulatum. Here, we report a 54-year-old diabetic male who presented with a history of progressive hoarseness of voice for 6 months. The patient was a chronic smoker for 15 years. A biopsy of the growth was done, and a histopathological examination of the tissue clinched the diagnosis of laryngeal histoplasmosis. The patient was managed with intravenous liposomal amphotericin B and oral itraconazole with complete resolution of symptoms.

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Chronic Cavitary Pulmonary Histoplasmosis in an Immunocompetent Patient

Albandak¹,

Azar²,

Ayyad³

et al. 2023

Cureus

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Histoplasma capsulatum is a fungal organism that causes systemic histoplasmosis. It is commonly asymptomatic in healthy immunocompetent individuals. The clinical symptoms of chronic cavitary histoplasmosis are typically seen in the immunodeficient population, particularly in smokers with preexisting structural lung disease. We report a case of chronic cavitary histoplasmosis in an immunocompetent patient from an endemic area without pre-existing structural lung pathology. She presented complaining of right hypochondrial pain and had no history of respiratory symptoms nor history suggestive of immunosuppression, tuberculosis, or recent travel. CT scan revealed a cavitary lung lesion and a hilar mediastinal mass. Biopsies obtained by bronchoscopy revealed signs of necrosis, granulomas, and the presence of fungal organisms consistent with histoplasmosis. Histoplasma antibodies by complement fixation for yeast antibodies test were positive establishing the diagnosis of chronic cavitary pulmonary histoplasmosis (CCPH). She was then started on itraconazole with good tolerance. On follow-up three months later, a chest CT done along with measurement of inflammatory markers and liver enzymes demonstrated complete clinical recovery. This case emphasizes the importance of expanding our current understanding of the clinical presentation and manifestations of histoplasmosis beyond the conventional assumption that severe disease only affects immunocompromised individuals.

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Laryngeal histoplasmosis: masquerading malignancy

Cited by 3 publications

References 24 publications

Histoplasmosis misdiagnosed as malignancies in immunocompetent and immunocompromised patients: A global perspective on clinical presentation, radiological and pathological findings

Histoplasmosis misdiagnosed as malignancies in immunocompetent and immunocompromised patients: A global perspective on clinical presentation, radiological and pathological findings

Histopathology of a polyploid laryngeal growth revealing disseminated histoplasmosis

Chronic Cavitary Pulmonary Histoplasmosis in an Immunocompetent Patient

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