Laryngeal giant cell tumour

Giant Cell Tumor of the Larynx Treated by Surgery and Adjuvant Denosumab: Case Report and Review of the Literature

“…The first case of GCTL was reported by Wesely in 1940 [5][6][7][8]. Since then a total of 33 additional cases have been published [3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”

“…Of the laryngeal structures, the thyroid cartilage is the most common site of origin (21, 60 %), followed by the cricoid cartilage (9, 26 %), the epiglottis (2, 6 %) and the soft tissues of the larynx (2, 6 %) [3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The location of one case was not specified [5][6][7][8] (Table 1).…”

“…Four authors reported normal laboratory values for serum calcium and three reported normal alkaline phosphatase levels, two of which also reported normal levels of parathyroid hormone. In eleven cases a history of tobacco use was elicited and was denied by all [3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The treatment modality was described in 32 of the 34 cases [3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”

“…The majority of cases were treated by surgery alone (19, 56 %), ranging from local excision to total laryngectomy. Eight cases were treated by surgery and radiation (24 %), three by radiation alone (9 %) and one case by surgery, radiation and chemo therapy (3 %) [3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Derbel et al [18] recently reported the use of denosumab following surgery in treating a single case of GCTL (3 %).…”

Giant Cell Tumor of the Larynx: A Clinicopathologic Series of Eight Cases and a Review of the Literature

“…Approximately 2% of all GCTs arise in the head and neck region, with the majority of them occurring in the sphenoid, ethmoid, or temporal bones (29 -32). Giant cell tumors arising primarily in the larynx are quite rare, with only individual case reports in the literature (n ϭ 20 cases; [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Giant cell tumors of the long bones almost always affect the mature skeleton (closed epiphyseal plates).…”