Laryngeal Angiosarcoma: A Clinicopathologic Study of Five Cases With a Review of the Literature

Loos, Benjamin M.; Wieneke, Jacqueline A.; Thompson, Lester D.�R.

doi:10.1097/00005537-200107000-00012

Cited by 22 publications

(27 citation statements)

References 27 publications

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“…Despite the fact that the majority of angiosarcomas affect the skin and soft tissues of the head and neck, angiosarcomas within the sinonasal tract account for \0.1% of all malignancies in this region [1,3,[3][4][5][6][7][8][9][10][11][12][13]. This study reports the largest single series of sinonasal tract angiosarcomas reported in the English language to date, with the vast majority of studies reporting only a single case [9,.…”

Section: Discussionmentioning

confidence: 97%

“…While angiosarcomas may occur in any region of the body, well over half occur in the head and neck, usually involving the skin and superficial soft tissues, particularly the scalp [1,[3][4][5][6][7]. Despite this fact, angiosarcoma accounts for less than 0.1% of all sinonasal tract malignancies [3,[8][9][10][11][12][13]. Primary sinonasal tract angiosarcomas are exceedingly uncommon and only a few cases have been reported in the English literature [9,.…”

Section: Introductionmentioning

confidence: 99%

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Sinonasal Tract Angiosarcoma: A Clinicopathologic and Immunophenotypic Study of 10 Cases with a Review of the Literature

Nelson

Thompson

2007

Head and Neck Pathol

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Sinonasal Tract Angiosarcoma: A Clinicopathologic and Immunophenotypic Study of 10 Cases with a Review of the Literature

Nelson

Thompson

2007

Head and Neck Pathol

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“…Loos et al [7] describe five cases of laryngeal angiosarcoma. Of these five cases, the most common site was the epiglottis and four of the patients had received prior radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Atypical vascular lesions (AVL) and angiosarcomas (AS) are lesions known to arise after radiation therapy [1][2][3][4][5][6][7][8][9][10][11][12]. They are most commonly described in the breast region status post radiation for breast carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Post-radiation Atypical Vascular Lesion/Angiosarcoma Arising in the Larynx

Mudaliar

Borrowdale

Mehrotra

2013

Head and Neck Pathol

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Atypical vascular lesions (AVL) and angiosarcomas (AS) are lesions known to arise after radiation therapy. These lesions can show overlap in both their gross and histologic pictures, and distinction between the two can be extremely challenging at times. They are known most commonly to arise in the breast region after radiation therapy. We present the first unique case of post-radiation AVL/AS arising in the larynx of a 51 year old woman, occurring 8 years after she received radiation for tonsillar squamous cell carcinoma.

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“…Loos et al reported five cases of primary angiosarcoma of the larynx with a history of previous radiation in two of their cases, pointing towards radiation being an aetiological factor. 13 LAS is twice more common in men than in women (male-to-female ratio: 2.3:1), with a mean age of 61 years at presentation. [14][15][16][17] It can affect any site in the larynx with the majority being in the supraglottis.…”

Section: Discussionmentioning

confidence: 99%

Primary angiosarcoma of the larynx: a rare entity

Katna

Deshmukh

Epari

et al. 2012

annals

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Angiosarcomas are extremely rare malignant tumours of the larynx. We present a case of laryngeal angiosarcoma in a 58-yearold man who presented with hoarseness of voice, dysphagia and neck swelling. The patient underwent a total laryngectomy with a pre-operative and frozen section diagnosis of a poorly differentiated carcinoma of the larynx. Histopathological and immunohistochemical evaluation revealed features of a laryngeal angiosarcoma. The case is presented for its rarity and diagnostic difficulty. KEywORdSAngiosarcoma -Supraglottis -Angioendothelioma Angiosarcoma is an uncommon, high grade neoplasm of vascular endothelial origin that can arise in any anatomical site of the body. Despite the fact that nearly 50% of all angiosarcomas occur in the skin and superficial soft tissues of the head and neck, they account for less than 0.1% of all head and neck malignancies. 1Livingston and Klemperer were the first to report the clinical features and histopathological characteristics of angiosarcoma.2 Jones, however, was the first to recognise the lesion as a distinct clinical entity. 3Over the years, a variety of terms have been used to describe this neoplasm, including haemangioendothelioma, angiosarcoma, haemangiosarcoma, malignant angioendothelioma and lymphangiosarcoma. Mucosal or organ-based angiosarcomas have been reported to arise in the nasal cavity, paranasal sinuses, orbit, temporal bone, middle ear, thyroid and larynx. Very few cases, however, have been described about this disease involving the larynx.4-8 Here we present a case of angiosarcoma involving the larynx with its management details in order to enhance the literature on this rare disease and its histopathological evaluation. Case historyWe report a rare case of a laryngeal angiosarcoma (LAS) in a 58-year-old man who presented at the head and neck services at our centre with a history of hoarseness, dysphagia and neck nodes. On clinical examination, endoscopy and direct laryngoscopy, a submucosal disease was revealed involving the left false vocal cord and ventricle. On computed tomography a diffuse mass involving bilateral vocal cords with erosion of the thyroid cartilage and disease extension into strap muscles with no subglottic extension of the disease was documented. Biopsy was suggestive of squamous cell carcinoma and in view of cartilage erosion and gross exolaryngeal spread of the disease, a total laryngectomy was planned.A total laryngectomy with a primary tracheo-oesophageal puncture with bilateral selective neck dissection was performed. On frozen section, the diagnosis was a poorly differentiated carcinoma with glandular differentiation. Gross examination of the histopathological specimen revealed a reddish brown tumour measuring 3cm x 2.5cm x 2cm involving the left glottis and bilateral subglottis. Underlying thyroid cartilage was grossly involved by the tumour. Microscopically, multiple sections showed a malignant tumour comprising tumour cells arranged in a vasoformative growth pattern with complex anastomosing channels an...

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Laryngeal Angiosarcoma: A Clinicopathologic Study of Five Cases With a Review of the Literature

Abstract: LA is a rare tumor, frequently associated with previous radiation, usually involving the supraglottis with characteristic histomorphologic and immunophenotypic features. LA has a poor prognosis, making appropriate separation from other conditions important.

Cited by 22 publications

References 27 publications

Sinonasal Tract Angiosarcoma: A Clinicopathologic and Immunophenotypic Study of 10 Cases with a Review of the Literature

Sinonasal Tract Angiosarcoma: A Clinicopathologic and Immunophenotypic Study of 10 Cases with a Review of the Literature

Post-radiation Atypical Vascular Lesion/Angiosarcoma Arising in the Larynx

Primary angiosarcoma of the larynx: a rare entity

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