Post-radiation Atypical Vascular Lesion/Angiosarcoma Arising in the Larynx

Abstract

Atypical vascular lesions (AVL) and angiosarcomas (AS) are lesions known to arise after radiation therapy. These lesions can show overlap in both their gross and histologic pictures, and distinction between the two can be extremely challenging at times. They are known most commonly to arise in the breast region after radiation therapy. We present the first unique case of post-radiation AVL/AS arising in the larynx of a 51 year old woman, occurring 8 years after she received radiation for tonsillar squamous cell carcinoma.

Atypical Vascular Proliferation Secondary to Radiotherapy in a Patient With a History of Synovial Sarcoma

“…AVP is a rare complication after treatment with radiotherapy [4], usually described after treatment of breast and other gynecological cancers [4,5], and less frequently in other types of neoplasms [6][7][8][9]. This complication is included in a spectrum of vascular entities in previously treated sites that includes benign lesions, atypical proliferation, and finally angiosarcoma [2,10,11].…”

Post‐radiation vascular lesions of the breast

“…Lately, AVLs have also been described in other locations such as scalp and larynx, following radiation therapy for hypothalamic pilocytic astrocytoma and squamous cell carcinoma, respectively. 6,7 AVLs are believed to arise as a consequence of lymphatic obstruction following radiotherapy and/or surgery, causing dilatation of superficial vascular channels. 8,9 Recent data show that the incidence of these lesions is similar after radiation in patients that underwent either breast-conserving therapy or total mastectomy.…”

“…They described four cases of AVL arising on irradiated skin following conservative treatment for breast carcinoma. Lately, AVLs have also been described in other locations such as scalp and larynx, following radiation therapy for hypothalamic pilocytic astrocytoma and squamous cell carcinoma, respectively . AVLs are believed to arise as a consequence of lymphatic obstruction following radiotherapy and/or surgery, causing dilatation of superficial vascular channels .…”

Atypical vascular proliferation after radiation for breast carcinoma atypical vascular proliferation

“…Despite the widespread use of radiation therapy to treat breast carcinoma, atypical vascular proliferation and angiosarcomas arising in the field of radiation therapy are rare. 1 Radiotherapy has short and long side effects. Months or even years later it may appear very tiny broken veins or they may grow on the surface of the treated area: telangiectasias.…”