Larvicidal activity of novel anthraquinone analogues and their molecular docking studies

Selvaraj, Keerthana; Ali, Daoud; Alarifi, Saud; Chidambaram, Sathish Kumar; Surendrakumar, Radhakrishnan; Idhayadhulla, Akbar

doi:10.1016/j.sjbs.2020.09.028

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…Furthermore, in a manner akin to the new synthetic compounds 1, 3, 5, 8, and 9, Pargyline serves as an MAO-B inhibitor. However, these novel molecules have displayed substantially enhanced effectiveness in the inhibition of MAO-B [11][12][13] (Tables 2 to 8).…”

Section: Resultsmentioning

confidence: 99%

New Amino-Anthracene-9, 10-Dione Derivatives: Synthesis and Pharmacological Evaluation as Powerful Neuroprotective and Antidepressant Agents

Suryawanshi,

Wagh

2023

IJPQA

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The monoamine oxidase (MAO) enzyme resides in the outer mitochondrial membranes of all body cells, including the ones found in the brain, liver, and intestinal mucosa. Dopamine, serotonin, norepinephrine, tyramine, and tryptamine are extrinsic and indigenous amines that MAO oxidatively deaminates. MAO-A has been correlated with depression and other mental health issues, while MAO-B has been associated with the conditions Alzheimer’s and Parkinson’s disease. In a targeted assessment of naturally occurring anthraquinones, two isoforms of recombinant human MAOs were utilized. The inhibitory effects of purpurin and alizarin on MAO-A were observed, with calculated IC50 values of 2.50 and 30.1 M, respectively. This research on anthraquinones, purpurin, and alizarin offers promising new information that might eventually be used as a lead molecule in the discovery of the unique synthetic anthraquinones, anthracene 9, 10-dione compounds 1 to 9. On 96-well black polystyrene microtiter plates, both MAOs inhibiting action of 9 distinct synthetic anthracene 9,10-dione compounds has been evaluated. Compared to clorgyline, compounds 1, 2, 5, 8, and 9 inhibit MAO-A significantly, while compounds 1, 3, 5, 8, and 9 considerably inhibit MAO-B. Significant findings indicate that these compounds may be beneficial When employed to treat depression owing to their intense selective MAO-B activity and antidepressant effects as a result of their selective MAO-inhibition.

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Section: Resultsmentioning

confidence: 99%

New Amino-Anthracene-9, 10-Dione Derivatives: Synthesis and Pharmacological Evaluation as Powerful Neuroprotective and Antidepressant Agents

Suryawanshi,

Wagh

2023

IJPQA

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Bio-efficacy of insecticidal molecule emodin against dengue, filariasis, and malaria vectors

Ragavendran

Balasubramani

Venkatesh

et al. 2023

Environ Sci Pollut Res

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Emodin, a chemical isolated from Aspergillus terreus, was studied using chromatographic and spectroscopic methods and compound purity (96%) was assessed by TLC. Furthermore, high larvicidal activity against Aedes aegypti-AeA (LC 50 5.08 and LC 90 8.23 mg.L − 1 ), Culex quinquefasciatus-CuQ (7.13 and 12.01 mg.L − 1 ), and Anopheles stephensi-AnS larvae (6.40 and 15.24 mg.L − 1 ) was recorded. The rst isolated fraction showed higher pupicidal activity against AeA (0.349 and 0.872 mg.L − 1 ). Most emodintreated larvae (ETL) involutate variations in acetylcholine esterase, α and β-carboxylesterases, and phosphatase activities in the 4th instar, indicating intrinsic differences in their biochemical changes. ETL had numerous altered tissues, including muscle, gastric caeca, hindgut, midgut, nerve ganglia, and midgut epithelium. Acute toxicity of emodin against brine shrimp Artemia nauplii (154.0 and 184.5 mg.L − 1 ) and the zebra sh Danio rerio (less toxicity observed) was evaluated. In docking studies, Emodin interacted well with odorant-binding-proteins of AeA, AnS, and CuQ with docking scores of -8.89, -6.53, and − 8.09 kcal/mole, respectively. Therefore, A. terreus is likely to be effective against mosquito larvicides.

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Gracilaria corticata red seaweed mediate biosynthesis of silver nanoparticles: larvicidal, neurotoxicity, molecular docking analysis, and ecofriendly approach

Naveenkumar

Kamaraj

Ragavendran

et al. 2023

Biomass Conv. Bioref.

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Larvicidal activity of novel anthraquinone analogues and their molecular docking studies

Cited by 5 publications

References 14 publications

New Amino-Anthracene-9, 10-Dione Derivatives: Synthesis and Pharmacological Evaluation as Powerful Neuroprotective and Antidepressant Agents

New Amino-Anthracene-9, 10-Dione Derivatives: Synthesis and Pharmacological Evaluation as Powerful Neuroprotective and Antidepressant Agents

Bio-efficacy of insecticidal molecule emodin against dengue, filariasis, and malaria vectors

Gracilaria corticata red seaweed mediate biosynthesis of silver nanoparticles: larvicidal, neurotoxicity, molecular docking analysis, and ecofriendly approach

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