Larvicidal Activity of Geranylacetone Derivatives against Culex quinquefasciatus Larvae and Investigation of Environmental Toxicity and Non-Target Aquatic Species

Abstract

A grindstone method based on Mannich condensation was used to synthesize geranylacetone derivatives (1a–1f). The method showed a high yield under milder reaction conditions. Analyses of the synthesized compounds were carried out by FTIR, 1H, 13C NMR, mass spectrometry, and elemental analysis. We synthesized and evaluated the larvicidal and ichthyotoxic activities of six compounds (1a–1f) in this study. Compound 1f (5,9-dimethyl-1-phenyl-3-(2-(3-phenylallylidene)hydrazinyl)deca-4,8-dien-1-one) was more active (LD50: 14.1 µg/mL) against the second instar larvae of Culex quinquefasciatus than geranylacetone (67.2 µg/mL), whereas the former caused 13.9% mortality at 100 µg/mL. Geranylacetone, in an antifeedant screening test, showed 53.1% against Oreochromis mossambicus within 24 h. The compound 1f showed high larvicidal activity against C. quinquefasciatus and was non-toxic to non-target aquatic species.

Mushroom tyrosinase enzyme catalysis: synthesis of larvicidal active geranylacetone derivatives against Culex quinquesfasciatus and molecular docking studies

“…Several plants, including rice, mango ( Dalavayi Haritha et al, 2021 ), and tomatoes, contain geranylacetone as an aromatic compound. Geranylacetone is produced when ozone degrades plant materials, along with other ketones ( Al-Zharani et al, 2021 ).…”

Aerobic and Anaerobic Digestion of Agro-Industrial and Livestock Wastes: A Green and Sustainable Way toward the Future

“…The effectiveness of the biomass depends on the pre-treatment techniques such as drying [5]. The ability of compost as effective pesticide is also a vital arena to be explored since chemicals used to target pests have toxic effect on the environment as well as its components [21]. Additionally, larvicidal agents containing phytocompounds derived from plant extracts are biodegradable and less-toxic [22].…”