Larvicidal Activity against <i>Aedes aegypti</i> and Chemical Characterization of the Inflorescences of <i>Tagetes patula</i>

Krzyzaniak, Letícia Maria; Antonelli-Ushirobira, Tânia Mara; Panizzon, Gean Pier; Sereia, Ana Luiza; Souza, José Roberto Pinto de; Zequi, João Antonio Cyrino; Novello, Cláudio Roberto; Lopes, Gisely Cristiny; Araújo, Daniela Cristina de Medeiros; Silva, Denise Brentan; Leite-Mello, Eneri Vieira de Souza; Mello, João Carlos Palazzo de

doi:10.1155/2017/9602368

Cited by 15 publications

(14 citation statements)

References 29 publications

(23 reference statements)

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“…Biomonitored phytochemical research aims to identify which substances are responsible for specific biological activities [37,38,39]. Biomonitored research involves studies across several knowledge areas to identify the bioactive compounds of interest [40].…”

Section: Discussionmentioning

confidence: 99%

Larvicidal Compounds Extracted from Helicteres velutina K. Schum (Sterculiaceae) Evaluated against Aedes aegypti L.

et al. 2019

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Helicteres velutina K. Schum (Sterculiaceae), a member of Malvaceae sensu lato, is a Brazilian endemic plant that has been used by the indigenous tribe Pankarare as an insect repellent. A previous study has reported the isolation of terpenoids, flavonoids and pheophytins, in addition to the larvicidal activity of crude H. velutina extracts derived from the aerial components (leaves, branches/twigs, and flowers). The present study reports the biomonitoring of the effects of fractions and isolated compounds derived from H. velutina against A. aegypti fourth instar larvae. A crude ethanol extract was submitted to liquid–liquid extraction with hexane, dichloromethane, ethyl acetate and n-butanol to obtain their respective fractions. Larvicidal evaluations of the fractions were performed, and the hexane and dichloromethane fractions exhibited greater activities than the other fractions, with LC50 (50% lethal concentration) values of 3.88 and 5.80 mg/mL, respectively. The phytochemical study of these fractions resulted in the isolation and identification of 17 compounds. The molecules were subjected to a virtual screening protocol, and five molecules presented potential larvicidal activity after analyses of their applicability domains. When molecular docking was analysed, only three of these compounds showed an ability to bind with sterol carrier protein-2 (1PZ4), a protein found in the larval intestine. The compounds tiliroside and 7,4′-di-O-methyl-8-O-sulphate flavone showed in vitro larvicidal activity, with LC50 values of 0.275 mg/mL after 72 h and 0.182 mg/mL after 24 h of exposure, respectively. This is the first study to demonstrate the larvicidal activity of sulphated flavonoids against A. aegypti. Our results showed that the presence of the OSO3H group attached to C-8 of the flavonoid was crucial to the larvicidal activity. This research supports the traditional use of H. velutina as an alternative insecticide for the control of A. aegypti, which is a vector for severe arboviruses, such as dengue and chikungunya.

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Section: Discussionmentioning

confidence: 99%

Larvicidal Compounds Extracted from Helicteres velutina K. Schum (Sterculiaceae) Evaluated against Aedes aegypti L.

et al. 2019

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“…Nanoparticles synthesized from marigold caused larval mortality and green synthesis of copper nanoparticles (CuNps) can kill the mosquito larvae of Culex quinquefasciatus [45]. Flowers of Tagetes patula are very effective natural larvicide and the larval mortality rate depended on the time elapsed and dose applied [46].…”

Section: Larvicidalmentioning

confidence: 99%

“…The root and floral extracts of Tagetes erecta showed considerable schizonticidal activity against Plasmodium falciparum [30] and mosquitocidal activity against Culex quinquefasciatus [49] respectively. Extracts of Tagetes patula [46] and Tagetes erecta [50] were effective against Aedes aegypti, the principal vector of dengue viruses.…”

Section: Mosquitocidalmentioning

confidence: 99%

Marigold: From Mandap to Medicine and from Ornamentation to Remediation

Mir¹,

Ahanger²,

Agarwal³

2019

AJPS

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Importance of medicinal plants to health care has been great and herbal preparations are being produced at industrial scale particularly in developing countries. The plant products obtained have a long history of use in therapeutics, aromatherapy and food depending on the chemical constituents and their bioactivity. In the recent past, marigolds have received a great attention in scientific research, because of their multiple use and also the information available about their phytochemistry and bioactivity. Tagetes species commonly known as marigold is native to Mexico, being used for medicinal and ornamental purposes. The plant is useful due to its unique phytoconstituents for a range of diseases and disorders and is reportedly effective against piles, kidney troubles, muscular pain, ulcers and wound healing and the flowers are helpful in fever, stomach and liver complaints and also in eye diseases. In India, marigold is also extensively used on religious and social occasions such as in the beautification of mandaps and pooja places; offerings at temples; marriage decorations and landscape planning due to variable size and colour of its flower. Present review is an effort to bring together the different strategies developed for the growth and cultivation of marigold, its ecophysiological and remediation relevance under a variety of environmental conditions and possible allelopathic potential. It includes reports on pharmacological aspects like antibacterial, antifungal, larvicidal, hepatoprotective, insecticidal, mosquitocidal, nematicidal, wound healing, antioxidant, anticancer and antidiabetic properties/activity of Tagetes.

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“…Aktivitas larvacidal ekstrak bonggol pisang ambon dievaluasi dengan memodifikasi metode yang dilakukan oleh Krzyzaniak 29 . Sebanyak 20 larva instar IV dimasukkan ke dalam beker glass berisi masing-masing ekstrak yang dilarutkan dalam 200 ml air keran.…”

Section: Aktivitas Larvacidalunclassified

Studi Toksisitas: Ekstrak Metanol Bonggol Pisang Ambon (Musa acuminata L. cv. Gros Michel) terhadap Aedes aegypti (Diptera: Culcidae)

2018

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Aedes aegypti mosquito is the main vector of dengue virus causing dengue hemorrhagic fever (DHF) in Indonesia. The main preventive action is to control the presence of Ae. aegypti mosquito. Banana plants are known to contain secondary metabolite compounds acting as a natural insecticide, including the hump part. This research was conducted to evaluate to toxicity of hump of Ambon banana extract (Musa acuminata L. cv. Gros Michel) to dengue vector Ae. aegypti mosquito. The research used experimental method, the treatment concentration was 0.001; 0.01; 0.1; 1; 10; 100 and 1000 ppm of Ambon banana methanol extract and 0 ppm concentration as a control, each with three replications. The variables observed were individual deaths at every stage of development and morphological damage. The data obtained were analyzed using the analysis of variety and Duncan test with 95% confidence level. In addition, probit analysis was used to determine the value of LC50. The results showed that the study of toxicity indicates that in the further stage of development, the toxicity of methanol extract from Ambon banana hump was less toxic. Toxicity of Ambon banana hump methanol extract was highest in egg with LC50 value of 314,852 ppm. The methanol extract of banana Ambon has the morphological destructive activity in all development stages of Ae. aegypti.Abstrak. Nyamuk Ae. aegypti merupakan vektor utama virus dengue penyebab demam berdarah dengue (DBD) di Indonesia. Upaya pencegahan utama adalah dengan mengendalikan keberadaan nyamuk Ae. aegypti. Tanaman pisang diketahui memiliki kandungan senyawa metabolit sekunder yang memiliki aktivitas sebagai insektisida nabati, termasuk bagian bonggol. Penelitian ini dilakukan untuk mengevaluasi daya toksisitas ekstrak metanol bonggol pisang ambon (Musa acuminata L. cv. Gros Michel) terhadap nyamuk vektor dengue Ae. aegypti. Metode penelitian yang digunakan adalah metode eksperimental dengan desain penelitian rancangan acak lengkap (RAL), perlakuan yang dicoba berupa konsentrasi ekstrak metanol bonggol pisang ambon 0,001; 0,01; 0,1; 1; 10; 100, 1000 ppm dan 0 ppm sebagai kontrol, masing-masing dengan tiga kali ulangan. Variabel yang diamati adalah kematian individu pada setiap tahap perkembangan dan kerusakan morfologi. Data yang diperoleh dianalisis menggunakan analisis ragam dan uji duncan dengan taraf kepercayaan 95%, dan untuk menentukan nilai LC50 menggunakan analisis probit dengan aplikasi SPSS 16. Hasil penelitian menunjukkan bahwa semakin lanjut tahap perkembangan nyamuk Ae. aegypti, ekstrak metanol bonggol pisang ambon semakin tidak toksik. Daya toksik ekstrak metanol bonggol pisang ambon paling tinggi pada telur dengan nilai LC50 314,852 ppm, dengan aktivitas berupa penghambatan penetasan telur, sedangkan paling rendah pada imago dengan nilai LC50 1755,077 ppm. Ekstrak metanol bonggol pisang ambon memiliki aktivitas merusak morfologi semua tahap perkembangan Ae. aegypti.

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Larvicidal Activity against Aedes aegypti and Chemical Characterization of the Inflorescences of Tagetes patula

Cited by 15 publications

References 29 publications

Larvicidal Compounds Extracted from Helicteres velutina K. Schum (Sterculiaceae) Evaluated against Aedes aegypti L.

Larvicidal Compounds Extracted from Helicteres velutina K. Schum (Sterculiaceae) Evaluated against Aedes aegypti L.

Marigold: From Mandap to Medicine and from Ornamentation to Remediation

Studi Toksisitas: Ekstrak Metanol Bonggol Pisang Ambon (Musa acuminata L. cv. Gros Michel) terhadap Aedes aegypti (Diptera: Culcidae)

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