Larvicidal activities of ginger (Zingiber officinale) against Angiostrongylus cantonensis

Lin, Rong-Jyh; Chen, Chung‐Yi; Chung, Li-Yu; Yen, Chuan-Min

doi:10.1016/j.actatropica.2009.12.007

Cited by 56 publications

(30 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, Allicin in the garlic acts by totally inhibiting RNA synthesis and partially inhibiting DNA and protein synthesis of the parasites (Feldberg et al 1988). Additionally, hexahydrocurcumin, a constituent isolated from the ginger, might be effective for killing the parasites (Lin et al 2010).…”

Section: Discussionmentioning

confidence: 99%

In vivo antiprotozoan effects of garlic (Allium sativum) and ginger (Zingiber officinale) extracts on experimentally infected mice with Blastocystis spp.

et al. 2015

View full text Add to dashboard Cite

Controversy surrounding the pathogenic role of Blastocystis spp. in humans and lack of well-established diagnostic criteria led to debates concerning the treatment for that organism. Furthermore, some strains develop resistance against the recommended drugs. Thus, using natural medicine has many positive aspects to address these points. In an earlier study, we addressed in vitro effect of garlic and ginger on Blastocystis spp. isolates as an alternative treatment. Accordingly, this study was conducted to evaluate in vivo activities of these two herbs on mice infected with Blastocystis spp. Antiprotozoan activities were determined by monitoring Blastocystis shedding in stools and histopathological changes of the intestine of infected mice. Additionally, assessment of the antioxidant effect (via measuring the level of malondialdehyde (MDA) production) of these herbs on the treated groups of mice was done. Also, their effects on nitric oxide (NO) production were assessed. In this work, treatment of infected mice with garlic, ginger, and nitazoxanide (NTZ) reduced the shedding of cysts significantly compared to the infected untreated group, P value ≤0.001, 0.0001, and 0.0003, respectively. As well, histopathological examination revealed that Blastocystis was frequently observed within the lumen, at the tip of the epithelium, and/ or infiltrated in an enterocyte in the infected group without treatment compared to that of the infected treated ones. Furthermore, mice infected with Blastocystis exhibited increased levels of NO (440.09 ± 3.7 vs. 276.66 ± 0.8, P ≤ 0.001) and MDA production (106.19 ± 0.43 vs. 63.06 ± 0.45, P ≤ 0.0004) compared to that of the uninfected controls. Treatment of infected mice with garlic, ginger, and NTZ reduced NO levels to 54.41 ± 1.2, 47.70 ± 1.2, and 37.43 ± 0.98 and MDA levels to 22.38 ± 0.17, 63.34 ± 3.89, and 66.76 ± 9.1, respectively. We conclude that using ginger and garlic for treatment of blastocystosis is beneficial.

show abstract

Section: Discussionmentioning

confidence: 99%

In vivo antiprotozoan effects of garlic (Allium sativum) and ginger (Zingiber officinale) extracts on experimentally infected mice with Blastocystis spp.

et al. 2015

View full text Add to dashboard Cite

show abstract

“…They were selected on the basis of their knowledge in treatment of some parasites. The anthelmintic efficacy of plant extract may be due to the presence of secondary metabolites particularly the alkaloids (Lin et al 2010). Extracts of several medicinal plants have been tested and proved to be effective against many helminth parasites (Abdel-Ghaffar et al 2011;Li et al 2012;Lin et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Efficacy % of 1000 mg curcumin on R. cesticillus (In vitro) In vitro efficacy percentage of curcumin at 1000 mg on R. cesticillusSanderson et al (2002) who showed that ginger (Z. officinale) exhibits anthelmintic activity against S. mansoni Lin et al (2010). studied its larvicidal activity against Angiostrongylus cantonensis.…”

mentioning

confidence: 99%

Anthelmintic activity of ginger, curcumin, and praziquentel against Raillietina cesticillus (in vitro and in vivo)

Elbahy

Bazh

2015

Parasitol Res

View full text Add to dashboard Cite

This work evaluates the anthelminitic activity of ginger and curcumin on the cestode Raillietina cesticillus. Live parasites were collected from intestine of naturally infected chickens in PBS 0.9 % and then incubated at 37 °C in media containing ginger extract at three different concentrations (125, 250, and 500 mg); every concentration was dissolved in 10 ml media. The curcumin extract was used at three different concentrations (250, 500, and 1000 mg); each was dissolved in 10 ml media. Praziquantel at a concentration of 600 mg was added to 10 ml media. A control one without extract was reported. Regression of worms increased gradually in all concentrations. At 500 mg ginger (50 ± 0 %), worms were regressed at 48 h post-exposure (h.p.e.). Also (50 ± 1.8 %), worms were regressed at 1000 mg curcumin at the same time. On the other hand, praziquantel showed the highest regression (65 ± 2.3 %). The extract efficacy was exhibit as concentration-time-dependent mainly at higher concentrations used after 48 h. In vivo effects of ginger and curcumin were lower than those in vitro.

show abstract

“…Iqbal et al (2006) showed that crude powder and crude aqueous extract of dried ginger possessed anthelmintic activity in sheep. Lin et al (2010a) suggested that the 6-gingerol, 10-shogaol, 10-gingerol, 6-shogaol and hexahydrocurcumin, a constituent isolated from the ginger might be used as larvicidal agents against Angiostrongylus cantonensis. Lin et al (2010b) investigated the anthelmintic activity of previous compounds against the nematode worm Anisakis simplex; they reported that these compounds kill or reduce spontaneous movement in A. simplex larvae.…”

Section: Introductionmentioning

confidence: 98%

Antischistosomal activity of ginger (Zingiber officinale) against Schistosoma mansoni harbored in C57 mice

2011

View full text Add to dashboard Cite

The repeated chemotherapy of schistosomiasis has resulted in the emergence of drug-resistant schistosome strains. The development of such resistance has drawn the attention of many authors to alternative drugs. Many medicinal plants were studied to investigate their antischistosomal potency. The present work aimed to evaluate antischistosomal activity of crude aqueous extract of ginger against Schistosoma mansoni. Sixteen mice of C57 strain were exposed to 100 ± 10 cercariae per mouse by the tail immersion method; the mice were divided into two groups: untreated group and ginger-treated one. All mice were sacrificed at the end of 10th week post-infection. Worm recovery and egg counting in the hepatic tissues and faeces were determined. Surface topography of the recovered worms was studied by scanning electron microscopy. Histopathological examination of liver and intestine was done using routine histological procedures. The worm burden and the egg density in liver and faeces of mice treated with ginger were fewer than in non-treated ones. Scanning electron microscopical examination revealed that male worms recovered from mice treated with ginger lost their normal surface architecture, since its surface showed partial loss of tubercles' spines, extensive erosion in inter-tubercle tegumental regions and numerous small blebs around tubercles. Histopathological data indicated a reduction in the number and size of granulomatous inflammatory infiltrations in the liver and intestine of treated mice compared to non-treated mice. The results of the present work suggested that ginger has antischistosomal activities and provided a basis for subsequent experimental and clinical trials.

show abstract

Larvicidal activities of ginger (Zingiber officinale) against Angiostrongylus cantonensis

Cited by 56 publications

References 30 publications

In vivo antiprotozoan effects of garlic (Allium sativum) and ginger (Zingiber officinale) extracts on experimentally infected mice with Blastocystis spp.

In vivo antiprotozoan effects of garlic (Allium sativum) and ginger (Zingiber officinale) extracts on experimentally infected mice with Blastocystis spp.

Anthelmintic activity of ginger, curcumin, and praziquentel against Raillietina cesticillus (in vitro and in vivo)

Antischistosomal activity of ginger (Zingiber officinale) against Schistosoma mansoni harbored in C57 mice

Contact Info

Product

Resources

About